ASSESSMENT OF OSTEOPOROSIS AND ANAEMIA RISK IN PATIENTS ON ANTICONVULSANT THERAPY

Objective: To assess the incidence of osteoporosis and anaemia in patients on anticonvulsant therapy and to educate those under risk.Methods: A prospective observational study was conducted on 50 study participants. The Bone mineral density (BMD), vitamin D, hematological parameters and peripheral smear were noted. Data analyzed using different statistical methods. Patient information brochures for osteoporosis and anaemia were distributed to those on chronic anti-epileptic drug (AED) therapy.Results: The prevalence of osteoporosis was 16% and osteopenia 22%. The BMD of subjects showed an Insignificant reduction in BMD when compared with a standard reference value for south asian population (*P>0.05). The mean BMD in single therapy group was higher compared with multiple therapy groups. BMD of the enzyme-inducing class was less compared with non-enzyme inducing class but was not significant (P>0.05). Duration of therapy was compared with BMD of patients showed a negative correlation. The relationship between duration of therapy and hematological parameters showed a negative correlation (r =-0.128). The mean haematological parameters in single AED therapy were higher when compared with multiple AED therapy. The study demonstrated 40% microcytic hypochromic and 4% macrocytic hypochromic morphology.Conclusion: Chronic therapy with AEDs possesses a significant risk of developing osteoporosis and anaemia. The incidence rate varies according to the type, duration, and mode of therapy. Early detection and management through diet exercise or pharmacotherapy will decrease the incidence of unwanted effects due to AEDs and improve the quality of life.Keywords: Bone mineral density, Antiepileptic drug, Osteoporosi

Conversational Repair Strategies in Adolescents with Autism Spectrum Disorders

The purpose of this case study was to explore the conversational repair responses of 3 adolescents with autism spectrum disorder (ASD) to communication breakdowns that occurred naturally in conversations. Adolescents with ASD are at the threshold of entry into independent living in society where their ability to manage communication breakdowns is essential. Of equal interest to the purposes of this study was describing how individuals with ASD were similar or different from each other in their sources of communication breakdowns, types of clarification requests, and repair responses used. The study used an embedded multiple-case study design to identify the sources of breakdowns, types of clarification requests made by the listener, and the types of repair responses used. Language samples were elicited across two conversational contexts (an Adult-Client context and a Peer with ASD context). A compiled coding system based on coding systems in the existing literature, pilot study findings, and those that emerged from the data was used to analyze the language samples. Results showed that all 3 participants exhibited and repaired breakdowns. Although similarities existed between the 3 participants in the types of repair responses used, they differed from each other in the variety of repair strategies used to resolve the breakdowns. Furthermore, the use of a compiled coding system enabled the identification of a pattern of strengths and weaknesses for each participant when faced with a communication breakdown. Investigations of linguistic pragmatics in autism are needed because they will generate information essential in designing effective assessments, interventions and support. The findings of this study are discussed with respect to prior theory and research, and its implications for the clinical and research fields

Marine Actinomycetes as Source of Antimicrobial Compounds and as Probiotics and Single Cell Protein for Application in Penaeid Prawn Culture Systems

This thesis Entitled Marine actinomycetes as source of antimicrobial compounds and as probiotics and single cell protein for application in penaeid peawn culture systems. Ocean harbours more than 80% of all life on earth and remains our greatest untapped natural resource. The study revealed the potential of marine actinomycetes as a source of antimicrobial compounds. The selected streptomycetes were found to be capable of inhibiting most of the pathogenic vibrios, whichis a major problem both in hatcheries and grow out systems. The bioactive principle can be incorporated with commercial feeds and applied as medicated diet for the control of vibrios in culture systems.The hydrolytic potential inhibitory property against pathogens and non—pathogenicity to penaeid prawns make the selected Streptomycesspp.an effective probioic in aquaculture. Since there is considerably less inhibition to the natural in pond ecosystem the microbial diversityis being maintained and thereby the water quality. Actinomycetes was found to be a good source of single cell protein as an ingredient inaquaculture feed formulations. Large amount of mycelial waste (actinomycete biomassO is produced from antibiotic industries and this nutrient rich waste can be effectively used as a protein source in aquaculture feeds.This study reveals the importance of marine actinomycetes as a source of antimicrobial compounds and as a probiotic and single cell protein for aquaculture applications.Cochin University of Science and TechnologySchool of Marine Science, Division of marine biology, microbiology and biochemistry,Cochin University of Science and Technolog