Pre-processing of the microvascular networks and the approach to assign boundary conditions.

<p>(A) Histogram-based upscaling approach for microvascular network 1. The grey and the black histogram show the original and the final diameter distribution, respectively. The mean, the standard deviation (std), the maximum value (max) and the minimum value (min) of all capillary diameters are stated in grey and black for the original and the final capillary diameter distribution, respectively. The red curve is the goal beta distribution. (B) Summary of the pressure measurements in the pial vasculature available in literature and the fit we used to assign the pressure boundary conditions at the pial arterioles. At the pial venules we uniformly prescribed a pressure of 10 mmHg. Data from: Harper [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005392#pcbi.1005392.ref007" target="_blank">7</a>], Werber [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005392#pcbi.1005392.ref008" target="_blank">8</a>], Hudetz [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005392#pcbi.1005392.ref044" target="_blank">44</a>], Shapiro [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005392#pcbi.1005392.ref009" target="_blank">9</a>]. (C) Schematic illustration of the steps of the hierarchical boundary condition approach. On the left the three different components of the full compound network are shown. The red and green spheres in the realistic implant represent the pial and capillary in- and outflows, respectively.</p

Number of available unique paths from DA+A to V+AV for the five ALs averaged over the RBC trajectories from 3 MVNs.

<p>Number of available unique paths from DA+A to V+AV for the five ALs averaged over the RBC trajectories from 3 MVNs.</p

Pearson’s correlation coefficient for the relative end point frequencies and five trajectory characteristics averaged over 3 MVNs.

<p>Pearson’s correlation coefficient for the relative end point frequencies and five trajectory characteristics averaged over 3 MVNs.</p

Validation of the simulation results with literature data.

<p>Validation of the simulation results with literature data.</p