3,358 research outputs found
Fabrication and performance analysis of 4-sq cm indium tin oxide/InP photovoltaic solar cells
Large-area photovoltaic solar cells based on direct current magnetron sputter deposition of indium tin oxide (ITO) into single-crystal p-InP substrates demonstrated both the radiation hardness and high performance necessary for extraterrestrial applications. A small-scale production project was initiated in which approximately 50 ITO/InP cells are being produced. The procedures used in this small-scale production of 4-sq cm ITO/InP cells are presented and discussed. The discussion includes analyses of performance range of all available production cells, and device performance data of the best cells thus far produced. Additionally, processing experience gained from the production of these cells is discussed, indicating other issues that may be encountered when large-scale productions are begun
Latest development of a W-band Gyro-TWA based on a helically corrugated interaction region
Latest development and experimental study of a W-band gyro-TWA with a helically corrugated waveguide and a cusp electron gun are presented. With an input seed signal from an 1.5 W, 90-96 GHz solid state source a gain of 27 dB was measured from the experiment. The bandwidth of the gyro-TWA was measured to be at least 5 GH
The cytoplasm of living cells: A functional mixture of thousands of components
Inside every living cell is the cytoplasm: a fluid mixture of thousands of
different macromolecules, predominantly proteins. This mixture is where most of
the biochemistry occurs that enables living cells to function, and it is
perhaps the most complex liquid on earth. Here we take an inventory of what is
actually in this mixture. Recent genome-sequencing work has given us for the
first time at least some information on all of these thousands of components.
Having done so we consider two physical phenomena in the cytoplasm: diffusion
and possible phase separation. Diffusion is slower in the highly crowded
cytoplasm than in dilute solution. Reasonable estimates of this slowdown can be
obtained and their consequences explored, for example, monomer-dimer equilibria
are established approximately twenty times slower than in a dilute solution.
Phase separation in all except exceptional cells appears not to be a problem,
despite the high density and so strong protein-protein interactions present. We
suggest that this may be partially a byproduct of the evolution of other
properties, and partially a result of the huge number of components present.Comment: 11 pages, 1 figure, 1 tabl
On the form of growing strings
Patterns and forms adopted by Nature, such as the shape of living cells, the
geometry of shells and the branched structure of plants, are often the result
of simple dynamical paradigms. Here we show that a growing self-interacting
string attached to a tracking origin, modeled to resemble nascent polypeptides
in vivo, develops helical structures which are more pronounced at the growing
end. We also show that the dynamic growth ensemble shares several features of
an equilibrium ensemble in which the growing end of the polymer is under an
effective stretching force. A statistical analysis of native states of proteins
shows that the signature of this non-equilibrium phenomenon has been fixed by
evolution at the C-terminus, the growing end of a nascent protein. These
findings suggest that a generic non-equilibrium growth process might have
provided an additional evolutionary advantage for nascent proteins by favoring
the preferential selection of helical structures.Comment: 4 pages, 3 figures. Accepted for publication in Phys. Rev. Let
Collisional kinetics of non-uniform electric field, low-pressure, direct-current discharges in H
A model of the collisional kinetics of energetic hydrogen atoms, molecules,
and ions in pure H discharges is used to predict H emission
profiles and spatial distributions of emission from the cathode regions of
low-pressure, weakly-ionized discharges for comparison with a wide variety of
experiments. Positive and negative ion energy distributions are also predicted.
The model developed for spatially uniform electric fields and current densities
less than A/m is extended to non-uniform electric fields, current
densities of A/m, and electric field to gas density ratios MTd at 0.002 to 5 Torr pressure. (1 Td = V m and 1 Torr =
133 Pa) The observed far-wing Doppler broadening and spatial distribution of
the H emission is consistent with reactions among H, H,
H, and H ions, fast H atoms, and fast H molecules, and with
reflection, excitation, and attachment to fast H atoms at surfaces. The
H excitation and H formation occur principally by collisions of
fast H, fast H, and H with H. Simplifications include using a
one-dimensional geometry, a multi-beam transport model, and the average
cathode-fall electric field. The H emission is linear with current
density over eight orders of magnitude. The calculated ion energy distributions
agree satisfactorily with experiment for H and H, but are only in
qualitative agreement for H and H. The experiments successfully modeled
range from short-gap, parallel-plane glow discharges to beam-like,
electrostatic-confinement discharges.Comment: Submitted to Plasmas Sources Science and Technology 8/18/201
Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease
The human papillomavirus (HPV) oncogenes, E6 and E7, are believed to contribute to the development of cervical cancers in women infected with certain HPV genotypes, most notably HPV-16 and HPV-18. Given their expression in tumor tissue, E6 and E7 have been implicated as potential tumor-specific antigens. We have examined an HPV-16 E6- and E7-transgenic mouse lineage for immune responses to these viral oncoproteins. Mice in this lineage express the HPV-16 E6 and E7 genes in their skin and eyes, and on aging, these mice frequently develop squamous cell carcinomas and lenticular tumors. Young transgenic mice, which had measurable E7 protein in the eye but not in the skin, were immunologically naive to E7 protein. They mounted an immune response to E7 on immunization comparable to that of nontransgenic controls, suggesting a lack of immune tolerance to this protein. Older line 19 mice, which are susceptible to skin disease associated with transcription of the E6 and E7 open reading frames, had measurable E7 protein in their skin. These older transgenic mice spontaneously developed antibody responses to endogenous E7 protein, particularly in association with skin disease. Also detected in older mice were delayed-type hypersensitivity responses to E7. These finding parallel the humoral immune response to E7 protein in patients with HPV-associated cervical cancer and suggest that line 19 mice may provide a model for studying the immunobiology of HPV-associated cancers
Developments of a W-band gyro-TWA for high PRF operation
Latest developments of a gyrotron travelling wave amplifier (gyro-TWA) with a helically corrugated waveguide and a cusp electron gun for operation over a bandwidth of 90-100 GHz at a high pulse repetition rate (5 kHz) are presented. Performance upgrades of the input coupler, pulsed power system and beam collector with water-cooling capability were realized for the high power wide band gyro-TWA
High-power free-electron Masers utilising 2D – 1D Bragg lasing cavities
We report the results from a coaxial 2D – 1D Bragg cavity based Free-Electron Maser, utilising a highcurrent (1.5kA), magnetically confined, thin annular electron beam with circumference of ~220mm, wall thickness of ~2mm and mean radius of ~35mm. The electron beam was transported through a 2m long coaxial drift-tube with inner and outer radii of 30 mm and 40mm respectively. Results obtained via numerical modelling and experimental observation are presented and compared
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