30 research outputs found
Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use
<p>Abstract</p> <p>Background</p> <p>The objective of this work was to study the vitamins B<sub>1</sub>, B<sub>2</sub>, B<sub>6 </sub>and C stability in a pediatric formulation containing high amounts of calcium in the presence of organic phosphate, amino acids, glucose, sodium chloride, magnesium sulfate, pediatric vitamins and trace elements under different conditions using developed and validated analytical methods.</p> <p>Methods</p> <p>The study was carried out during 72 h with formulations packaged in recommended storage temperature (4°C) and 25°C, with and without photoprotection.</p> <p>Results</p> <p>The results showed that the methodologies used for assessing the chemical stability of vitamins B<sub>1</sub>, B<sub>2</sub>, B<sub>6 </sub>and C in the formulation were selective, linear, precise and accurate. The vitamins could be considered stable in the formulation during the three days of study if stored at 4°C. When stored at 25°C vitamin C presented instability after 48 h.</p> <p>Conclusion</p> <p>The pediatric formulation containing high amount of calcium in the presence of organic phosphate, amino acids, glucose, sodium chloride, magnesium sulphate, pediatric vitamins and trace elements packaged in bag-type trilaminate presented a shelf life of the 72 h, when maintained under refrigeration, between 2°C and 8°C. This shelf life was measured considering the vitamins studied. Further studies are needed including all the vitamins present in this formulation.</p
A Study of the Effect of Kosmotropic and Chaotropic Ions on the Release Characteristics of Lignin Microcapsules under Stimuli-Responsive Conditions
Stimuli-responsive behavior of lignin micro- capsules (LMCs) has been investigated along with the detailed characterization of their stability profiles. The disassembly of LMCs was found to be salt species-dependent, indicating the specific relevance of inherent kosmotropic and chaotropic characteristics. For the first time, a connection between the Hofrneister series and the stability profile of lignin microscale materials is established. LMCs showed excellent stability in water and under high temperature and pressure (autoclaving conditions). Active release is efficiently triggered by pH changes and balancing chaotropic and kosmotropic effects via salinity tuning
Intensive Insulin Therapy in Critically Ill Hospitalized Patients: Making it Safe and Effective
The use of plant cell suspension cultures in studies of the metabolism of pesticides or other foreign chemicals
HPLC Column Classification
ABSTRACT This Stimuli article represents the conclusions and recommendations of the USP Working Group on HPLC Columns. The working group included the five largest manufacturers of HPLC columns in the United States, along with the National Institute of Standards and Technology (NIST) and USP. This work attempts to facilitate the selection of HPLC columns by the analyst when performing a USP test