Linkage between regulatory region SNPs and correlation of haplotypes with plasma TNF levels

<p><b>Copyright information:</b></p><p>Taken from "Polymorphisms of -enhancer and gene for FcγRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population"</p><p>http://www.malariajournal.com/content/7/1/13</p><p>Malaria Journal 2008;7():13-13.</p><p>Published online 14 Jan 2008</p><p>PMCID:PMC2245971.</p><p></p> A, rLD plot of four SNPs (-1031, -863, -308, -238). Value in each cell is the percent D' between SNP pairs. B, Correlation of promoter haplotype (-1031C, -863A, -857C, -308G, -238G) with elevated TNF levels compared to the major haplotype TCCGG. Mean plasma TNF levels were compared using Mann-Whitney test (z = -3.73, P = 0.0002). C, Plasma TNF level in patients and controls. Pairwise comparison of means by non-parametric Mann-Whitney test: severe versus control, z = 4.41, P < 0.0001; non-severe versus control, z = 0.67, P = 0.25; severe versus non-severe, z = 3.13, P = 0.0009