52 research outputs found
Melanoma of the Anus Disguised as Hemorrhoids: Surgical Management Illustrated by a Case Report
A clinical diagnostic model for predicting influenza among young adult military personnel with febrile respiratory illness in Singapore
10.1371/journal.pone.0017468PLoS ONE63
Ileostomy or colostomy for temporary decompression of colorectal anastomosis: systematic review and meta-analysis
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Priorities to inform research on marine plastic pollution in Southeast Asia
This is the final version. Available from Elsevier via the DOI in this record. Southeast Asia is considered to have some of the highest levels of marine plastic pollution in the world. It is therefore
vitally important to increase our understanding of the impacts and risks of plastic pollution to marine ecosystems and
the essential services they provide to support the development of mitigation measures in the region. An interdisciplinary, international network of experts (Australia, Indonesia, Ireland, Malaysia, the Philippines, Singapore, Thailand, the
United Kingdom, and Vietnam) set a research agenda for marine plastic pollution in the region, synthesizing current
knowledge and highlighting areas for further research in Southeast Asia. Using an inductive method, 21 research questions emerged under five non-predefined key themes, grouping them according to which: (1) characterise marine plastic pollution in Southeast Asia; (2) explore its movement and fate across the region; (3) describe the biological and
chemical modifications marine plastic pollution undergoes; (4) detail its environmental, social, and economic impacts;
and, finally, (5) target regional policies and possible solutions. Questions relating to these research priority areas highlight the importance of better understanding the fate of marine plastic pollution, its degradation, and the impacts and
risks it can generate across communities and different ecosystem services. Knowledge of these aspects will help support
actions which currently suffer from transboundary problems, lack of responsibility, and inaction to tackle the issue
from its point source in the region. Being profoundly affected by marine plastic pollution, Southeast Asian countries
provide an opportunity to test the effectiveness of innovative and socially inclusive changes in marine plastic governance, as well as both high and low-tech solutions, which can offer insights and actionable models to the rest of the
world.Natural Environment Research CouncilNational Research Foundation, Prime Minister’s Office (Singapore
Comparison of predictive equations for resting energy expenditure in severely obese Caucasian children and adolescents
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