Two new guaiane sesquiterpene lactones from the aerial parts of <i>Artemisia vulgaris</i>

<p>Two new guaiane sesquiterpene lactones, vulgarolides A and B (<b>1</b> and <b>2</b>), were isolated from <i>Artemisia vulgaris</i> aerial parts using various chromatographic separations. The structure elucidation was performed by combination of spectroscopic experiments including 1D and 2D NMR, HR ESI MS, and CD. Their <i>in vitro</i> cytotoxic activities against five human cancer cell lines were also evaluated using SRB method.</p

A new rearranged abietane diterpene from <i>Clerodendrum inerme</i> with antioxidant and cytotoxic activities

<p>Eight compounds were isolated from the leaves of <i>Clerodendrum inerme</i>, including one new rearranged abietane diterpene, crolerodendrum B (<b>1</b>). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds <b>1</b>, <b>3</b> and <b>4</b> exhibited strong DPPH radical-scavenging effects (ED₅₀ values of 17.6 ± 2.1, 10.1 ± 0.8 and 11.3 ± 0.3 μM, respectively) and <b>4</b> showed strong cytotoxicity against the HCT116 cell line (IC₅₀ = 3.46 ± 0.01 μM).</p