1,635 research outputs found

    Postoperative pain after arthroscopic versus open rotator cuff repair. A prospective study

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    Introduction: Although the arthroscopic technique is becoming the gold standard for rotator cuff tendon repair, there is no proof that this technique results in less postoperative pain compared to open repair. The aim of this study was to prospectively compare the postoperative pain level after arthroscopic or open rotator cuff repair and to define factors that could influence its course. Materials and methods: Between January 2012 and January 2013, 95 patients were operated for a rotator cuff tear: 45 using an arthroscopic technique and 50 an open technique. Daily analgesic use and self-evaluation of pain level using a visual analogic scale were recorded preoperatively and twice a day postoperatively during the first 6 weeks. These data were compared between the two groups and analyzed according to patients’ demographic data and preoperative evaluation of the tear. Results: The preoperative pain level was equivalent in the two groups (P = 0.22). Postoperatively, level-2 analgesic medication use was greater in the arthroscopic group after the 4th week (P = 0.01). A painfree shoulder was obtained before the 6th week in 75% and 66% of the patients after arthroscopic or open repair, respectively (P = 0.34). There was a positive correlation between the preoperative and postoperative pain level (r = 0.25; P = 0.02). Work compensation patients experienced more pain postoperatively (P = 0.08). Level-III analgesic medication use was greater for patients with massive rotator cuff tear (P = 0.001). Conclusion: No evidence was found on the superiority of arthroscopy versus open repair of rotator cuff tear concerning the postoperative pain level. The choice of the surgical technique should not be based on this argument

    Differential Seroprevalence of Human Bocavirus Species 1-4 in Beijing, China

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    BACKGROUND: Four species of human bocaviruses (HBoV1-4) have been identified based on phylogenetic analysis since its first report in 2005. HBoV1 has been associated with respiratory disease, whereas HBoV2-4 are mainly detected in enteric infections. Although the prevalence of HBoVs in humans has been studied in some regions, it has not been well addressed globally. METHODOLOGY/PRINCIPAL FINDINGS: Cross-reactivity of anti-VP2 antibodies was detected between HBoV1, 2, 3, and 4 in mouse and human serum. The prevalence of specific anti-VP2 IgG antibodies against HBoV1-4 was determined in different age groups of healthy individuals aged 0-70 years old in Beijing, China, using a competition ELISA assay based on virus-like particles of HBoV1-4. The seroprevalence of HBoV1-4 was 50%, 36.9%, 28.7%, and 0.8%, respectively, in children aged 0-14 years (n = 244); whereas the seroprevalence of HBoV1-4 was 66.9%, 49.3%, 38.7% and 1.4%, respectively, in healthy adults (≥ 15 years old; n = 142). The seropositive rate of HBoV1 was higher than that of HBoV2, HBoV3, and HBoV4 in individuals older than 0.5 years. Furthermore, IgG seroconversion of HBoV1 (10/31, 32.3%), HBoV2 (8/31, 25.8%), and HBoV3 (2/31, 6.5%) was found in paired sera collected from children with respiratory tract infections who were positive for HBoV1 according to PCR analysis. CONCLUSIONS/SIGNIFICANCE: Our data indicate that HBoV1 is more prevalent than HBoV2, HBoV3, and HBoV4 in the population we sampled in Beijing, China, suggesting that HBoV species may play differential roles in disease

    DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

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    To address the increasing need for detecting and validating protein biomarkers in clinical specimens, mass spectrometry (MS)-based targeted proteomic techniques, including the selected reaction monitoring (SRM), parallel reaction monitoring (PRM), and massively parallel data-independent acquisition (DIA), have been developed. For optimal performance, they require the fragment ion spectra of targeted peptides as prior knowledge. In this report, we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue samples. To build the spectral resource, we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on Docker. We then applied the workflow to generate DPHL, a comprehensive DIA pan-human library, from 1096 data-dependent acquisition (DDA) MS raw files for 16 types of cancer samples. This extensive spectral resource was then applied to a proteomic study of 17 prostate cancer (PCa) patients. Thereafter, PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was validated. As a second application, the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma (DLBCL) patients and 18 healthy control subjects. Differentially expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by PRM. These data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker discovery. DPHL is freely accessible at https://www.iprox.org/page/project.html?id=IPX0001400000

    Measurements of the branching fractions for BKγB \to K^{*}\gamma decays at Belle II

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    This paper reports a study of BKγB \to K^{*}\gamma decays using 62.8±0.662.8\pm 0.6 fb1^{-1} of data collected during 2019--2020 by the Belle II experiment at the SuperKEKB e+ee^{+}e^{-} asymmetric-energy collider, corresponding to (68.2±0.8)×106(68.2 \pm 0.8) \times 10^6 BBB\overline{B} events. We find 454±28454 \pm 28, 50±1050 \pm 10, 169±18169 \pm 18, and 160±17160 \pm 17 signal events in the decay modes B0K0[K+π]γB^{0} \to K^{*0}[K^{+}\pi^{-}]\gamma, B0K0[KS0π0]γB^{0} \to K^{*0}[K^0_{\rm S}\pi^{0}]\gamma, B+K+[K+π0]γB^{+} \to K^{*+}[K^{+}\pi^{0}]\gamma, and B+K+[K+π0]γB^{+} \to K^{*+}[K^{+}\pi^{0}]\gamma, respectively. The uncertainties quoted for the signal yield are statistical only. We report the branching fractions of these decays: B[B0K0[K+π]γ]=(4.5±0.3±0.2)×105,\mathcal{B} [B^{0} \to K^{*0}[K^{+}\pi^{-}]\gamma] = (4.5 \pm 0.3 \pm 0.2) \times 10^{-5}, B[B0K0[KS0π0]γ]=(4.4±0.9±0.6)×105,\mathcal{B} [B^{0} \to K^{*0}[K^0_{\rm S}\pi^{0}]\gamma] = (4.4 \pm 0.9 \pm 0.6) \times 10^{-5}, B[B+K+[K+π0]γ]=(5.0±0.5±0.4)×105, and\mathcal{B} [B^{+} \to K^{*+}[K^{+}\pi^{0}]\gamma] = (5.0 \pm 0.5 \pm 0.4)\times 10^{-5},\text{ and} B[B+K+[KS0π+]γ]=(5.4±0.6±0.4)×105,\mathcal{B} [B^{+} \to K^{*+}[K^0_{\rm S}\pi^{+}]\gamma] = (5.4 \pm 0.6 \pm 0.4) \times 10^{-5}, where the first uncertainty is statistical, and the second is systematic. The results are consistent with world-average values

    Angular analysis of B+ρ+ρ0B^+ \to \rho^+\rho^0 decays reconstructed in 2019, 2020, and 2021 Belle II data

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    We report on a Belle II measurement of the branching fraction (B\mathcal{B}), longitudinal polarization fraction (fLf_L), and CP asymmetry (ACP\mathcal{A}_{CP}) of B+ρ+ρ0B^+\to \rho^+\rho^0 decays. We reconstruct B+ρ+(π+π0(γγ))ρ0(π+π)B^+\to \rho^+(\to \pi^+\pi^0(\to \gamma\gamma))\rho^0(\to \pi^+\pi^-) decays in a sample of SuperKEKB electron-positron collisions collected by the Belle II experiment in 2019, 2020, and 2021 at the Υ\Upsilon(4S) resonance and corresponding to 190 fb1^{-1} of integrated luminosity. We fit the distributions of the difference between expected and observed BB candidate energy, continuum-suppression discriminant, dipion masses, and decay angles of the selected samples, to determine a signal yield of 345±31345 \pm 31 events. The signal yields are corrected for efficiencies determined from simulation and control data samples to obtain $\mathcal{B}(B^+ \to \rho^+\rho^0) = [23.2^{+\ 2.2}_{-\ 2.1} (\rm stat) \pm 2.7 (\rm syst)]\times 10^{-6},, f_L = 0.943 ^{+\ 0.035}_{-\ 0.033} (\rm stat)\pm 0.027(\rm syst),and, and \mathcal{A}_{CP}=-0.069 \pm 0.068(\rm stat) \pm 0.060 (\rm syst).Theresultsagreewithpreviousmeasurements.Thisisthefirstmeasurementof. The results agree with previous measurements. This is the first measurement of \mathcal{A}_{CP}in in B^+\to \rho^+\rho^0$ decays reported by Belle II

    Determination of Vub|V_{ub}| from untagged B0π+νB^0\to\pi^- \ell^+ \nu_{\ell} decays using 2019-2021 Belle II data

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    We present an analysis of the charmless semileptonic decay B0π+νB^0\to\pi^- \ell^+ \nu_{\ell}, where =e,μ\ell = e, \mu, from 198.0 million pairs of BBˉB\bar{B} mesons recorded by the Belle II detector at the SuperKEKB electron-positron collider. The decay is reconstructed without identifying the partner BB meson. The partial branching fractions are measured independently for B0πe+νeB^0\to\pi^- e^+ \nu_{e} and B0πμ+νμB^0\to\pi^- \mu^+ \nu_{\mu} as functions of q2q^{2} (momentum transfer squared), using 3896 B0πe+νeB^0\to\pi^- e^+ \nu_{e} and 5466 B0πμ+νμB^0\to\pi^- \mu^+ \nu_{\mu} decays. The total branching fraction is found to be (1.426±0.056±0.125)×104(1.426 \pm 0.056 \pm 0.125) \times 10^{-4} for B0π+νB^0\to\pi^- \ell^+ \nu_{\ell} decays, where the uncertainties are statistical and systematic, respectively. By fitting the measured partial branching fractions as functions of q2q^{2}, together with constraints on the nonperturbative hadronic contribution from lattice QCD calculations, the magnitude of the Cabibbo-Kobayashi-Maskawa matrix element VubV_{ub}, (3.55±0.12±0.13±0.17)×103(3.55 \pm 0.12 \pm 0.13 \pm 0.17) \times 10^{-3}, is extracted. Here, the first uncertainty is statistical, the second is systematic and the third is theoretical

    Observation of BD()KKS0{B\to D^{(*)} K^- K^{0}_S} decays using the 2019-2022 Belle II data sample

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    We present a measurement of the branching fractions of four B0,D()+,0KKS0B^{0,-}\to D^{(*)+,0} K^- K^{0}_S decay modes. The measurement is based on data from SuperKEKB electron-positron collisions at the Υ(4S)\Upsilon(4S) resonance collected with the Belle II detector and corresponding to an integrated luminosity of 362 fb1{362~\text{fb}^{-1}}. The event yields are extracted from fits to the distributions of the difference between expected and observed BB meson energy to separate signal and background, and are efficiency-corrected as a function of the invariant mass of the KKS0K^-K_S^0 system. We find the branching fractions to be: B(BD0KKS0)=(1.89±0.16±0.10)×104, \text{B}(B^-\to D^0K^-K_S^0)=(1.89\pm 0.16\pm 0.10)\times 10^{-4}, B(B0D+KKS0)=(0.85±0.11±0.05)×104, \text{B}(\overline B{}^0\to D^+K^-K_S^0)=(0.85\pm 0.11\pm 0.05)\times 10^{-4}, B(BD0KKS0)=(1.57±0.27±0.12)×104, \text{B}(B^-\to D^{*0}K^-K_S^0)=(1.57\pm 0.27\pm 0.12)\times 10^{-4}, B(B0D+KKS0)=(0.96±0.18±0.06)×104, \text{B}(\overline B{}^0\to D^{*+}K^-K_S^0)=(0.96\pm 0.18\pm 0.06)\times 10^{-4}, where the first uncertainty is statistical and the second systematic. These results include the first observation of B0D+KKS0\overline B{}^0\to D^+K^-K_S^0, BD0KKS0B^-\to D^{*0}K^-K_S^0, and B0D+KKS0\overline B{}^0\to D^{*+}K^-K_S^0 decays and a significant improvement in the precision of B(BD0KKS0)\text{B}(B^-\to D^0K^-K_S^0) compared to previous measurements

    Measurement of the branching fraction for the decay BK(892)+B \to K^{\ast}(892)\ell^+\ell^- at Belle II

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    We report a measurement of the branching fraction of BK(892)+B \to K^{\ast}(892)\ell^+\ell^- decays, where +=μ+μ\ell^+\ell^- = \mu^+\mu^- or e+ee^+e^-, using electron-positron collisions recorded at an energy at or near the Υ(4S)\Upsilon(4S) mass and corresponding to an integrated luminosity of 189189 fb1^{-1}. The data was collected during 2019--2021 by the Belle II experiment at the SuperKEKB e+ee^{+}e^{-} asymmetric-energy collider. We reconstruct K(892)K^{\ast}(892) candidates in the K+πK^+\pi^-, KS0π+K_{S}^{0}\pi^+, and K+π0K^+\pi^0 final states. The signal yields with statistical uncertainties are 22±622\pm 6, 18±618 \pm 6, and 38±938 \pm 9 for the decays BK(892)μ+μB \to K^{\ast}(892)\mu^+\mu^-, BK(892)e+eB \to K^{\ast}(892)e^+e^-, and BK(892)+B \to K^{\ast}(892)\ell^+\ell^-, respectively. We measure the branching fractions of these decays for the entire range of the dilepton mass, excluding the very low mass region to suppress the BK(892)γ(e+e)B \to K^{\ast}(892)\gamma(\to e^+e^-) background and regions compatible with decays of charmonium resonances, to be \begin{equation} {\cal B}(B \to K^{\ast}(892)\mu^+\mu^-) = (1.19 \pm 0.31 ^{+0.08}_{-0.07}) \times 10^{-6}, {\cal B}(B \to K^{\ast}(892)e^+e^-) = (1.42 \pm 0.48 \pm 0.09)\times 10^{-6}, {\cal B}(B \to K^{\ast}(892)\ell^+\ell^-) = (1.25 \pm 0.30 ^{+0.08}_{-0.07}) \times 10^{-6}, \end{equation} where the first and second uncertainties are statistical and systematic, respectively. These results, limited by sample size, are the first measurements of BK(892)+B \to K^{\ast}(892)\ell^+\ell^- branching fractions from the Belle II experiment
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