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Wisconsin (P30 HD05876) and to the Center for Demography of Health and Aging, University of Wisconsin (P30 AG17266). 2 Context. We know precious little about adult health in developing countries in general and Latin America in particular. We know even less about the health conditions of elderly individuals. Since Mexico and many other countries in Latin America and the Caribbean region are and will continue to experience a very rapid process of aging, it is important to generate pertinent information and analyze it promptly to identify key features that could be used to formulate and design health policies. This is particularly useful in Mexico, and other countries of the region, which have embarked in sweeping reforms of the health sector. Objective. We aim to investigate the health profile of elderly Mexicans aged 50 and over. We are guided by two overarching concerns. First, does the health profile of elderly Mexicans reveal any special features, distinct from what one would expect from extant research on elderly individuals? Second, is there any evidence of relation

SUBJECT: PESTICIDE VOLATILE ORGANIC COMPOUND EMISSION ADJUSTMENTS FOR FIELD CONDITIONS AND ESTIMATED VOLATILE ORGANIC COMPOUND REDUCTIONS–INITIAL ESTIMATES

The purposes of this memorandum is to develop refined emission adjustment factors to account for the effect of application method on volatile organic compound (VOC) emissions from pesticides, with particular emphasis on fumigants, and to estimate the VOC reductions associated with changes to fumigant application methods. Each year, the Department of Pesticide Regulation (DPR) updates an inventory of pesticide VOC emissions for May–October for specified areas and compares the emissions on a relative basis to 1990 or 1991 as the base year. DPR currently assumes 100 % of applied fumigants volatilize to the air. Field monitoring data shows that fumigant emissions are less than 100 % and vary with application method. There are several dozen field studies that measured fumigant emissions. Emissions vary from 9 to 100 % of the amount applied, depending on the fumigant and application method. However, data is not available for all application methods in current use or in use during the 1990/91 base year. When no data is available, emissions have been estimated with surrogate data. In addition to emission estimates associated with each application method, DPR has estimated the frequency with which the various application methods were used during 1990/91 base year, as well as currently. Registrant data and pesticide use reports (PURs) were used for these estimates

Disciplining the muse : evaluating creative writing studies’ effort to establish itself as an academic discipline

textDisciplinarity in the humanities has long been neglected by writing-in-the-disciplines (WID) scholars in favor of science and business writing. Disciplining the Muse argues that there is much for WID scholars to learn by investigating non-traditional fields that make claims for disciplinarity; additionally, emerging and contested disciplines offer insight into the nature of disciplinarity itself. My work bridges WID issues of disciplinary definition and development by looking at one extreme case within English Studies: creative writing studies (CWS). CWS rhetorically disidentifies with literature, composition and traditional creative writing while inspiring cohesion within their own field. Complicating this project, long-held ambivalence towards disciplinarity within creative writing creates a riff between the vanguard and many practitioners. The CWS vanguard declares disciplinary criteria of research, pedagogy and institutional sanction in order to bolster their claims. Instead of using outsider definitions of disciplinarity, in this dissertation I employ qualitative and quantitative research methods to evaluate the gap between the vanguard’s disciplinary claims and practices. The material and cultural implications of being a discipline can be high, and WID scholars should seek for the insider view for new disciplines—how well developing disciplines live up to their own stated standards and aspirations.Englis

Ovarian serous adenocarcinoma identified during IVF: diagnostic approach, surgical management, and reproductive outcome

BACKGROUND: To present a diagnostic evaluation and treatment strategy for serous adenocarcinoma of the ovary discovered during an in vitro fertilisation (IVF) sequence, and report on reproductive outcome after tumour resection and embryo transfer. CASE PRESENTATION: Cycle monitoring in IVF identified an abnormal ovarian lesion which was subjected to ultrasound-guided needle aspiration. Cytology suggested malignancy, and unilateral oophorectomy was performed after formal staging. After surgery, the patient underwent an anonymous donor oocyte IVF cycle which established a viable twin intrauterine pregnancy. No recurrence of cancer has been detected in the >72 month follow-up interval; mother and twin daughters continue to do well. CONCLUSION: Suspicious adnexal structures noted during controlled ovarian hyperstimulation for IVF warrant assessment, and this report confirms the role of aspiration cytology in such cases. If uterine conservation is possible, successful livebirth can be achieved from IVF if donor oocyes are utilised, as described here

Repetition avoidance in human language

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 2007.Includes bibliographical references (p. 208-225).Repetition is avoided in countless human languages and at a variety of grammatical levels. In this dissertation I ask what it is that makes repetition so bad. I propose that at least three distinct biases against repetition exist. First, repetition of articulatory gestures is relatively difficult. This difficulty results in phonetic variation that may lead to categorical phonological avoidance. I call this set of claims the Biomechanical Repetition Avoidance Hypothesis (BRAH), and support it with evidence from cross-linguistic patterns in repetition avoidance phenomena, articulatory data from music performance, and a series of phonetic experiments that document the proposed types of phonetic variation. Based on these data, I give an evolutionary account for antigemination in particular. The second anti-repetition bias is a perceptual deficit causing speakers not to perceive one of a sequence of repeated items, of any conceptual category. This bias is already well-documented, as are the grammatical effects (primarily haplology). I provide here the evidence of gradient variation in production bridging the two, from avoidance of homophone sequences in English corpora. The third factor is a principle disallowing the repetition of syntactic features in certain configurations within a phase domain. I document categorical effects of it in Semitic syntax of possession and relativization. These elicit repair strategies superficially similar to those of phonology (specifically, deletion and epenthesis/insertion). Repetition effects, then, are traceable to a variety of independent, functional biases. This argues against a unitary, innate constraint against repetition. Rather, multiple anti-repetition biases result in particular avoidance patterns, with their intersection producing additional asymmetries. Possible categorical repairs are further constrained by the nature of the formal grammatical system.by Mary Ann Walter.Ph.D

Role of substrate gating and activation by ClpX

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010."January 2010." Cataloged from PDF version of thesis.Includes bibliographical references.AAA+ self-compartmentalized proteases are an important class of proteome regulators that operate to selectively degrade protein substrates. All of these enzymes share the architectural theme of a hexameric ring unfoldase stacked axially onto a barrel-like peptidase, with six- or seven-fold symmetry and sequestered active sites. ClpXP is a model self-compartmentalized protease composed of the regulator ClpX and the serine protease ClpP. Proteolysis occurs by ClpX-dependent substrate selection, unfolding, and translocation into the degradation lumen of ClpP, where rapid and relatively non-specific peptide hydrolysis generates small peptide products. Prior work had shown that ClpP is unable to degrade polypeptides in the absence of ClpX, suggesting the existence of a mechanism that inhibits the activity of free ClpP. Structures of free ClpP show active sites geometrically competent to perform peptide-hydrolysis chemistry. However, some biochemical results suggested that N-terminal ClpP residues, which line the axial entrance pores, allosterically regulate these active sites. Through measurements of ClpP active-site reactivity, degradation of size-varied peptides, and mutagenesis of the N-termini, I found that peptide degradation is inhibited by steric occlusion, maintained by the N-terminal 3-stem loop and a-helix A of ClpP. The N-termini also participate in specifying substrate choice, as mutations within the axial channel prevent degradation of peptides containing stretches of charged amino acids. These data support a model in which ClpX binding opens the axial pore of ClpP to facilitate polypeptide translocation.(cont.) Additional residues in ClpP that are important for its function were identified by a selection for dominant-negative mutants impaired in ClpXP-dependent proteolysis. Biochemical studies and mapping of these mutations onto the structure of ClpP suggest that these variants are defective in tetradecamer assembly, peptide binding at the active sites, and ClpX binding. This work provides a foundation for further investigations of the mechanisms of ClpP assembly, degradation, and interactions with ClpX.by Mary Elizabeth Lee.Ph.D

Predicting Students' Degree Completion Using Decision Trees

Educational Data Mining (EDM) helped institutions to improve students' performance by predicting student's future learning behavior. To benefit from this, the researchers conducted this study to predict the successful degree completion and provide early intervention as necessary. Decision Tree algorithm provided by WEKA is used to build the model using students' data such as Entrance Exam Results, gender, school type where they graduated high school and final grades from English 1, Algebra and major subjects. Students who entered the University from school years 2012-2013, 2013-2014, 2014-2015 and 2015-2016 were selected. RandomForest suited best for the model and desktop application was designed and evaluated as Outstanding in terms of Efficiency, Accuracy and User Friendliness.

Are Ethnic and Gender Specific Equations Needed to Derive Fat Free Mass from Bioelectrical Impedance in Children of South Asian, Black African-Caribbean and White European Origin? Results of the Assessment of Body Composition in Children Study

Background Bioelectrical impedance analysis (BIA) is a potentially valuable method for assessing lean mass and body fat levels in children from different ethnic groups. We examined the need for ethnic- and gender-specific equations for estimating fat free mass (FFM) from BIA in children from different ethnic groups and examined their effects on the assessment of ethnic differences in body fat. Methods Cross-sectional study of children aged 8–10 years in London Primary schools including 325 South Asians, 250 black African-Caribbeans and 289 white Europeans with measurements of height, weight and arm-leg impedance (Z; Bodystat 1500). Total body water was estimated from deuterium dilution and converted to FFM. Multilevel models were used to derive three types of equation {A: FFM = linear combination(height+weight+Z); B: FFM = linear combination(height2/Z); C: FFM = linear combination(height2/Z+weight)}. Results Ethnicity and gender were important predictors of FFM and improved model fit in all equations. The models of best fit were ethnicity and gender specific versions of equation A, followed by equation C; these provided accurate assessments of ethnic differences in FFM and FM. In contrast, the use of generic equations led to underestimation of both the negative South Asian-white European FFM difference and the positive black African-Caribbean-white European FFM difference (by 0.53 kg and by 0.73 kg respectively for equation A). The use of generic equations underestimated the positive South Asian-white European difference in fat mass (FM) and overestimated the positive black African-Caribbean-white European difference in FM (by 4.7% and 10.1% respectively for equation A). Consistent results were observed when the equations were applied to a large external data set. Conclusions Ethnic- and gender-specific equations for predicting FFM from BIA provide better estimates of ethnic differences in FFM and FM in children, while generic equations can misrepresent these ethnic differences

Prospective randomized trial evaluating mandatory second look surgery with HIPEC and CRS vs. standard of care in patients at high risk of developing colorectal peritoneal metastases

<p>Abstract</p> <p>Background</p> <p>The standard of care for colorectal peritoneal carcinomatosis is evolving from chemotherapy to cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with disease limited to the peritoneum. Peritoneal carcinomatosis from colorectal cancer treated with chemotherapy alone results in median survival of 5 to 13 months, whereas CRS with HIPEC for early peritoneal carcinomatosis from colorectal cancer resulted in median survival of 48-63 months and 5 year survival of 51%.</p> <p>Completeness of cytoreduction and limited disease are associated with longer survival, yet early peritoneal carcinomatosis is undetectable by conventional imaging. Exploratory laparotomy can successfully identify early disease, but this approach can only be justified in patients with high risk of peritoneal carcinomatosis. Historical data indicates that patients presenting with synchronous peritoneal carcinomatosis, ovarian metastases, perforated primary tumor, and emergency presentation with bleeding or obstructing lesions are at high risk of peritoneal carcinomatosis. Approximately 55% of these patient populations will develop peritoneal carcinomatosis. We hypothesize that performing a mandatory second look laparotomy with CRS and HIPEC for patients who are at high risk for developing peritoneal carcinomatosis from colorectal cancer will lead to improved survival as compared to patients who receive standard of care with routine surveillance.</p> <p>Methods/Design</p> <p>This study is a prospective randomized trial designed to answer the question whether mandatory second look surgery with CRS and HIPEC will prolong overall survival compared to the standard of care in patients who are at high risk for developing peritoneal carcinomatosis from colorectal cancer (CRC). Patients with CRC at high risk for developing peritoneal carcinomatosis who underwent curative surgery and subsequently received standard of care adjuvant chemotherapy will be evaluated. The patients who remain without evidence of disease by imaging, physical examination, and tumor markers for 12 months after the primary operation will be randomized to mandatory second look surgery or standard-of-care surveillance. At laparotomy, CRS and HIPEC will be performed with intraperitoneal oxaliplatin with concurrent systemic 5-fluorouracil and leucovorin. Up to 100 patients will be enrolled to allow for 35 evaluable patients in each arm; accrual is expected to last 5 years.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov ID: NCT01095523</p

Molecular Plasticity of E-Cadherin and Sialyl Lewis X Expression, in Two Comparative Models of Mammary Tumorigenesis

The process of metastasis involves a series of steps and interactions between the tumor embolus and the microenvironment. Key alterations in adhesion molecules are known to dictate progression from the invasive to malignant phenotype followed by colonization at a distant site. The invasive phenotype results from the loss of expression of the E-cadherin adhesion molecule, whereas the malignant phenotype is associated with an increased expression of the carbohydrate ligand-binding epitopes, (e.g. Sialyl Lewis (x/a)) that bind endothelial E-selectin of the lymphatics and vasculature.Our study analyzed the expression of two adhesion molecules, E-cadherin and Sialyl Lewis x (sLe(x)), in both a canine mammary carcinoma and human inflammatory breast cancer (IBC) model, using double labelled immunofluorescence staining.Our results demonstrate that canine mammary carcinoma and human IBC exhibit an inversely correlated cellular expression of E-cadherin and sLe(x) within the same tumor embolus.Our results in these two comparative models (canine and human) suggest the existence of a biologically coordinated mechanism of E-cadherin and sLe(x) expression (i.e. molecular plasticity) essential for tumor establishment and metastatic progression