Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells

The study provides new evidence that the mRNA-destabilizing protein Tristetraprolin is a modulator of HIF-1α mRNA turnover and may contribute to the control of HIF-1α and HIF-1α target gene expression during the adaptive response of endothelial cells to hypoxia