Study protocol for an international, multicentre stepped-wedge cluster randomised trial to evaluate the impact of a digital antimicrobial stewardship smartphone application

Introduction With the widespread use of electronic health records and handheld electronic devices in hospitals, informatics-based antimicrobial stewardship interventions hold great promise as tools to promote appropriate antimicrobial drug prescribing. However, more research is needed to evaluate their optimal design and impact on quantity and quality of antimicrobial prescribing. Methods and analysis Use of smartphone-based digital stewardship applications (apps) with local guideline directed empirical antimicrobial use by physicians will be compared with antimicrobial prescription as per usual as primary outcome in three hospitals in the Netherlands, Sweden and Switzerland. Secondary outcomes will incl

Novel User-friendly Device for Human Bite Force Measurement

Statement of Problem: Bite force is generated due to the consonance between different parts of the masticatory system. In dentistry, measurement of the bite force is quite common through several methods and devices. Objective: The aim was to present a novel bite force-measuring device that could help reducing the costs. Materials and Methods:This study presented the design, fabrication, and calibration method of a novel low-cost bite force-measuring device based on a force-sensitive resistor and application of strain gages. The FSR 402 was the selected sensor, which was suitable in size for placement in mouth, sterilizable for reuse, and contained biocompatible material.It could measure a large bite force of up to 90 kg with high repeatability.The device had a liquid crystal display (LCD) for immediate visualization of the results and a system for quick calibration of the device in office. To assess the accuracy of the device, some forces were applied to the sensor in nine values from11 to 80kg. The mean of measured force, absolute error, and error percentage were measured and recorded. Results: The mean relative error was almost 2% within the range of 11-80kg. The lowest error percentage was 0.46% at the load of 52kg and the highest error percentage was 3.97% at the load of 28 kg.Error percentage was 2.51% in the lowest range (11kg) and 2.65% in the highest range (80kg).The relative error in different ranges did not follow a particular trend. Conclusions:The bite force-measuring device is an economical and user-friendly appliance that can be simply used for routine practice in the office. The device shows good linearity and repeatability. It also has a calibration apparatus that can help maintaining the device accuracy

Assessment of Brown Bear\'s (Ursus arctos syriacus) Winter Habitat Using Geographically Weighted Regression and Generalized Linear Model in South of Iran

Winter dens are one of the important components of brown bear's (Ursus arctos syriacus) habitat, affecting their reproduction and survival. Therefore identification of factors affecting the habitat selection and suitable denning areas in the conservation of our largest carnivore is necessary. We used Geographically Weighted Logistic Regression (GWLR) and Generalized Linear Model (GLM) for modeling suitability of denning habitat in Kouhkhom region in Fars province. In the present research, 20 dens (presence locations) and 20 caves where signs of bear were not found (absence locations) were used as dependent variables and six environmental factors were used for each location as independent variables. The results of GLM showed that variables of distance to settlements, altitude, and distance to water were the most important parameters affecting suitability of the brown bear's denning habitat. The results of GWLR showed the significant local variations in the relationship between occurrence of brown bear dens and the variable of distance to settlements. Based on the results of both models, suitable habitats for denning of the species are impassable areas in the mountains and inaccessible for humans

A state-of-the-art protocol to minimize the internal concentration polarization in forward osmosis membranes

© 2020 Elsevier B.V. The main reason for the lower water flux, than expected, in the forward osmosis (FO) process, is the internal concentration polarization (DICP). Usually, the structural parameter (S) is used as an indicator of the intensity of DICP. Small S value is desirable for the FO membrane due to the low DICP. However, due to design and construction problems, structural parameter reduction has some drawbacks. In this work, DICP reduction in FO membranes will be investigated using an approach other than structural parameter reduction. Accordingly, during the FO process, the feed solution (FS) valve is opened and closed at a constant period of time (feed valve timing (FVT)). Four types of FO membranes with different S parameters were used. The effects of the implementation of the proposed protocol on the water flux (Jw), reverse salt flux (Js), specific reverse solute flux (Js/Jw) and effective driving force were investigated. The effects of the S parameter and draw solution (DS) concentration also investigated separately. The results showed that the proposed protocol significantly increased Jw. Also, the values of Js/Jw decreased with increasing the FVT values and reached the lowest level in the practical recovery time (PRT)