Age- and sex-adjusted linear regression analyses demonstrating relationships of bilirubin with thyroid hormones, components of the metabolic syndrome, insulin, insulin resistance and total cholesterol.

<p>HDL, high density lipoprotein; HOMA-IR, homeostasis model assessment-insulin resistance; β, standardized regression coefficient. Bilirubin, TSH, glucose, insulin and HOMA-IR and triglycerides were log transformed.</p

Multivariable linear regression models demonstrating the interaction between free T₄ and insulin resistance on bilirubin.

<p>HOMA-IR, Homeostasis model assessment-insulin resistance; AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; β, standardized regression coefficient. Bilirubin, HOMA-IR, AST and ALT were log transformed.</p

Clinical characteristics, glucose, insulin, insulin resistance, lipids, transaminases, and thyroid hormones in 1854 subjects.

<p>Data in mean ± SD or in median (interquartile range). BMI, body mass index; HOMA-IR, homeostasis model assessment-insulin resistance; HDL, high density lipoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; β, standardized regression coefficient. <i>P</i>-values for linear trend are shown. Bilirubin, glucose, insulin, HOMA-IR, triglycerides, TSH, AST and ALT were log transformed.</p

Graphical presentation of the interaction of free T₄ with insulin resistance on bilirubin.

<p>The standardized regression coefficients of the interaction term obtained by multivariable linear regression analysis as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090886#pone-0090886-t003" target="_blank">Table 3</a>, model 3 is used.</p