A dynamic approach merging network theory and credit risk techniques to assess systemic risk in financial networks

V. L. acknowledges support from the EPSRC project EP/N013492/1

A haptic-enabled multimodal interface for the planning of hip arthroplasty

Multimodal environments help fuse a diverse range of sensory modalities, which is particularly important when integrating the complex data involved in surgical preoperative planning. The authors apply a multimodal interface for preoperative planning of hip arthroplasty with a user interface that integrates immersive stereo displays and haptic modalities. This article overviews this multimodal application framework and discusses the benefits of incorporating the haptic modality in this area

Tinnitus revival during COVID‑19 lockdown: how to deal with it?

To the Editor, The novel Coronavirus Disease, officially designated as COVID-19 by the WHO, is a serious issue for public health. To contain the COVID-19, the Italian Government stated on March 9th 2020 the prohibition of any movement throughout the national area unless for work/health reasons and the obligation to remain as much as possible inside one’s own home. With the start of the so-called “Phase Two” on May 4th 2020, circulation within the same region was allowed again, due to the progressive slowdown of the outbreak. Therefore, since lockdown measures were relaxed and access to the emergency room or ENT clinic became less worrying for patients, specialists of Otolaryngology Units in Bari (Italy) observed an increase in the amount of subjects complaining of the revival of intense tinnitus. We attempt in this letter to focus on patients affected by chronic subjective tinnitus, that already had a diagnosis and self-stabilized without a massive treatment. Research studies have reported tinnitus wide impact on quality of life of subjects experiencing it, involving their emotional state, concentration and sleep quality; at this regard, Tinnitus Handicap Inventory (THI) is a self-reported tool regularly used to quantify the grade of perceived handicap as slight (0–16), mild (18–36), moderate (38–56), severe (58–76) or catastrophic (78–100) on the basis of 25 questions [1]. During the past 2 weeks, we have collected data from 16 patients among our population of chronic sufferers: THI observed was moderate in 62.5% and severe in 18.75% of cases, catastrophic in 12.5% and mild in 6.25% of subjects. Interestingly, the grade of handicap resulted increased by one-level in 12 out of 16 patients (75%); in particular, THI shifted from mild to moderate in 9 patients and from moderate to severe in 3 patients. As shown in the literature, tinnitus generation, maintenance and recrudescence are still debated. A cortical reorganization secondary to sensory deprivation has been proposed as one on the most frequent cause of tinnitus [2]. The avoidance of silence and acoustic masking have been proposed as effective measures to overcome sensory deprivation and increase masking of the symptom [3]. It is reasonable to think that, during the lockdown, the absence of environmental masking sounds from everyday life may have enhanced the tinnitus perception. Furthermore, proneness to worry and incoming stress during pandemic could be included as further potential risk factors for tinnitus worsening. As proficiently reviewed in a recent work [4], some internet/smartphone-based applications provide in tinnitus patients adequate counseling and interactive information together with sound therapy. As brain networks implicated in adaptive responses to sound stimuli and to worry are shared in many cases, an early decrease of anxiety status may release neural resources crucial for tinnitus habituation/distress perception [5]. In general, interactive platforms have been widely implemented during lockdown period due to the forced lack of real personal and working relationships; since smart-working seems to be successful for future plans, the development of smart applications and mobile services in the health care field may be promising in terms of cost-effectiveness, tolerability and simplicity of use

Numerical investigations about the sound transmission loss of a fuselage panel section with embedded periodic foams

The scope of this paper is to investigate the sound transmission loss of a typical fuselage panel section, as well as to propose solutions based on the inclusion of a periodic pattern inside its foam core, which aim at passively improving the acoustic performance in a mid-high range of frequencies. In detail, a new fuselage panel configuration is numerically studied, starting from the state of the art regarding the acoustic packages based on porous meta-materials. The main novelties of the present work are represented by the application of a meta-core solution inside an acoustic package of aeronautical interest, as well as a systematic investigation of the effects deriving from its geometrical parameters. In order to reach this goal, a numerical model of a fuselage panel section is studied, and the effect of several periodic patterns are simulated; more specifically, twelve configurations are taken into account, each with different radius of the inclusions and number of unit cells along the thickness. For each of these layouts, the mass increase of the so-called meta-core, compared to that of its classical homogeneous counterpart, is estimated, together with the associated mid-band frequency and amplitude of the sound transmission loss peak, which is caused by the additional acoustic modes excited by the periodic nature of the meta-core itself. Results are presented in terms of tables and graphs, which may constitute a good basis in order to perform preliminary design considerations that could be interesting for further generalizations

The Importance of Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic

Neutralizing antibodies are considered a correlate of protection against SARS-CoV-2 infection and severe COVID-19, although they are not the only contributing factor to immunity: T-cell responses are considered important in protecting against severe COVID-19 and contributing to the success of vaccination effort. T-cell responses after vaccination largely mirror those of natural infection in magnitude and functional capacity, but not in breadth, as T-cells induced by vaccination exclusively target the surface spike glycoprotein. T-cell responses offer a long-lived line of defense and, unlike humoral responses, largely retain reactivity against the SARS-CoV-2 variants. Given the increasingly recognized role of T-cell responses in protection against severe COVID-19, the circulation of SARS-CoV-2 variants, and the potential implementation of novel vaccines, it becomes imperative to continuously monitor T-cell responses. In addition to “classical” T-cell assays requiring the isolation of peripheral blood mononuclear cells, simple whole-blood-based interferon-γ release assays have a potential role in routine T-cell response monitoring. These assays could be particularly useful for immunocompromised people and other clinically vulnerable populations, where interactions between cellular and humoral immunity are complex. As we continue to live alongside COVID-19, the importance of considering immunity as a whole, incorporating both humoral and cellular responses, is crucial.</p

Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas

The bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin. Consequently, preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular, histological and pathophysiological features. Intraepithelial neoplasms are reported in biliary tract, as biliary intraepithelial neoplasm (BilIN), and in pancreas, as pancreatic intraepithelial neoplasm (PanIN). Both can evolve to invasive carcinomas, respectively cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC). Intraductal papillary neoplasms arise in biliary tract and pancreas. Intraductal papillary neoplasm of the biliary tract (IPNB) share common histologic and phenotypic features such as pancreatobiliary, gastric, intestinal and oncocytic types, and biological behavior with the pancreatic counterpart, the intraductal papillary mucinous neoplasm of the pancreas (IPMN). All these neoplastic lesions exhibit similar immunohistochemical phenotypes, suggesting a common carcinogenic process. Indeed, CCA and PDAC display similar clinic-pathological features as growth pattern, poor response to conventional chemotherapy and radiotherapy and, as a consequence, an unfavorable prognosis. The objective of this review is to discuss similarities and differences between the neoplastic lesions of the pancreas and biliary tract with potential implications on a common origin from similar stem/progenitor cells

Experimental study of graphene and carbon nanotubes thermal sensing properties

Today there are several new and interesting Nano-particle materials on the market providing good electrical conductivity. Examples are carbon Nano-tubes and different versions of graphene derivatives, often provided as powder. In particular, the materials available were Multi-Walled Carbon Nanotubes in Epoxy matrix and Reduced Graphene Oxide (rGOH). An initial literature survey underlined the lack of measurements and information about the conductivity of these materials during heating up or curing. This work is part of a larger project aiming at producing ”sensing structural composite material”, i.e. a composite material with integrated Nanoparticles, as eg. Carbonnano-tubes or graphene, working as sensors reporting the status of the material during heating up, curing and/or tensioning. The principal results concerns the evaluation of the specific conductivity during heating for both materials (rGOH and MWCNT in Epoxy Matrix) with the realization of an experimental model for the gradient of the specific conductivity with temperature. The linearity underlines the possibility of using the properties of these materials to create sensors, not only for strain (with the advantage of high Gauge Factors), but also for temperature

Passive noise control oriented design of aircraft headrests

Two Passive Noise Control (PNC) concepts were numerically evaluated in terms of their impact on the Sound Pressure Level (SPL) perceived by passengers of an aircraft flight. A concept was based on the shape optimization of the headrests, whereas the second one was based on the adoption of a high absorbing material, i.e. a nanofiber textile, to improve the acoustic performances of the headrests. To this aim, an aircraft seat was modelled with the Boundary Element Method (BEM) and loaded with a spherical distribution of monopole sources surrounding the seat. Different configurations of headrest shape and covering textiles were then compared in terms of the SPL calculated at passengers’ ears. The work shows how an acoustic-oriented design of the aircraft headrests could achieve an average SPL reduction for passengers up to 3 dBA

Initial experimental investigations on natural fibre reinforced honeycomb core panels

The main attention of the present work is on eco-friendly honeycomb cores for sandwich panels. They are manufactured by combining flax fibres with polyethylene matrix; the analyses involve both reinforced and un-reinforced cores. Some experimental tests have been planned and carried out in order to qualify the modal characteristics of this important class of panels. Tests results, herein discussed, report a great improvement of reinforced cores (continuous-unidirectional and short-random) compared to un-reinforced ones in mechanical properties. An improvement in damping value is achieved by filling the core with wool fibres resulting in minimal weight increase. A summary of the impact and acoustic tests results of preview tests are also reported in order to have a global view of the behaviour of these sandwich panels