EFFICACY OF NEBIVOLOL IN TREATMENT OF WOMEN WITH CORONARY HEART DISEASE

Aim. Evaluation of clinical efficacy and tolerability of beta-blockers in premenopausal women with stable angina.Material and methods. The anaysis of 43-55 years old premenopausal 50 women with stable angina was performed. Therapy included enalapril 2,5-10 mg daily, betaadrenoblocker in 1 group (23 persons) – 5-10 mg of bisoprolol daily, and in 2 group (27 pers.) nebivolol 2,5-5 mg daily (Nebilet®, “Berlin-Chemie/A. Menarini”, Germany), acetylsalycilic acid 100 mg daily during 6 months. The studies done were veloergometry, long-lasting ECG monitoring, echocardiography and also the test with reactive hyperemia on brachial artery. Severity of anxiety-depressive syndrome was evaluated usin hospital scale of anxiety and depression, and the severity of climacteric disorders – by the M. Kuppermann index.Results. With the therapy all patients self-reported improvement of their condition: in 80% there was a decrease of angina functional class, more significant in the second group. Also there was decrease of climacteric symptoms salience as anxiety-depressive disorders, especially in nebivolol group. By the results of ECG monitoring, i. e. frequency of rhythm dosirders (supraventricular and ventricular arrhythmias) there was lower quantity of episodes, more significant in nebivolol group. All groups showed an increase of basal brachial artery diameter, more significant in the 2nd group. Also we marked the changes in central hemodynamics parameters and sctructure-functional parameters of the left ventricle in both groups. Conclusion. Nebilet® in saily dose as 2,5-5 mg is an effective antianginal drug in women with CHD and stable angina pectoris. Under Nebilet® action there is improvement of systolic and diastolic functions of the left ventricle myocardium. With Nebilet® women with stable angina significantly increase exercise tolerance and there is a decrease of climacteric and anxiety-depressive syndrome

Galectin-3, N-terminal Propeptides of Type I and III Procollagen in Patients with Atrial Fibrillation and Metabolic Syndrome

The aim of this study was to determine the concentration of galectin-3, PINP and PIIINP in patients with metabolic syndrome (MS) and atrial fibrillation (AF) with an assessment of the relationship with severity of left atrium fibrosis. A total of 480 subjects were included in the case-control study: MS patients (n = 337), 176 of whom had AF, 72 patients with AF without MS and 71 healthy subjects. Galectin-3, PINP and PIIINP blood concentrations and metabolic parameters were compared with the severity of left atrium fibrosis, measured by CARTO3. Galectin-3 in AF and MS patients is higher than in MS without AF and in healthy subjects (10.3 (4.8–15.4), 5.1 (4.3–8.8), 3.2 (2.4–4.2) ng/mL, p < 0.0001). Galectin-3 serum concentration in AF patients with MS is higher than in patients without MS: 10.3 (4.8–15.4), 6.8 (5.2–8.1) ng/mL, p = 0.0001. PINP and PIIINP concentration were higher in patients with AF and MS than in MS without AF: 3499.1 (2299.2–4567.3), 2130.9 (1425.3–2861.8) pg/mL, p < 0.0001, 94.9 (64.8–123.5), 57.6 (40.5–86.9) ng/mL, p < 0.0001. Galectin-3 correlates with PINP (r = 0.496, p < 0.001) and PIIINP concentration (r = 0.451, p < 0.0001). The correlation between galectin-3, PINP and the severity of left atrium fibrosis was found (r = 0.410, p < 0.001; r = 0.623, p < 0.001). Galectin-3 higher than 12.6 ng/mL increased the risk of AF more than five-fold. High galectin-3, PINP and PIIINP concentrations were associated with heart remodeling in MS patients and increased the risk of AF

The clinical and epidemiological characteristics of the tuberculosis in children and adolescents of Poltavshina in new conditions

Результати дослідження засвідчили, що педіатрична служба проводить недостатню профілактичну роботу з виявлення хворих дітей в осередках туберкульозної інфекції, особливо серед тих, які мають контак- ти з дорослими, хворими на туберкульоз. Недостатньо ефективна профілактична робота ведеться в епідемічних осередках туберкульозної інфекції. Недостатньою є ефективність масової туберкулінодіагностики, про що свідчить виявлення майже третини хворих при зверненні за медичною допомогою і велика (31,45%) кількість дітей із сімейного контакту;Проведен анализ заболеваемости у детей и подростков Полтавщины в сравнении с организационными противотуберкульозными мероприятиями у 124 больных туберкулезом, которые в период 2001-2005 годов прошли пол-ный курс лечения в детском отделении Полтавского обласного противоту-беркулезного диспансера. Установлено, что рост заболеваемости туберкулезом у детей и подростков в последние 10 лет сопровождался низкой эффективностью организационных мероприятий по профилактике и раннему выявлению туберкулеза у детей в группах диспансерного учета, у детей из эпидочагов туберкулеза, а также ухудшением диагностики туберкулеза и низкой эффективностью массовой туберкулинодиагностики, проводимых педиатрической сетью; Epidemiological data on tuberculosis in children and adolescents for the last 10 years were juxtaposition with the clinical data by 124 patients age 2-17 years, who had tuberculosis of different localization. The increase of morbidity by tuberculosis was accompanied with decrease of efficiency in the prophilaxy and early emerdgence of the disease in the tuberculosis pesthole, the impairment of diagnosis of tuberculosis and mass tuberculin test