Knjiga o Danijelu u Brevijaru Vida Omišljanina

An edition of the Book of Daniel (chapters 1-5:4) in the archaic Breviary of Vid of Omišalj with the Latin transliteration is published in the paper. This breviary (1396) is the only Croato-Glagolitic manuscript that contains four chapters of this biblical book. It combines different textual layers: 1) the early Parimijnik (Prophetologion) translation which is supposed to have been made from Greek already in the Cyrillo-Methodian period; 2) the so-called Symeonic complete version (most probably a commentated one) produced in the period of the First Bulgarian Kingdom in Northeastern Bulgarian lands against a different Greek original; and 3) a new stratum reflecting a translation from and/or redaction against a Latin original (Vulgate) produced by Croatian glagoljaši. Therefore, the edition of the Book of Daniel in the Breviary of Vid of Omišalj could serve as a basis for further study of the textual history of the Book of Daniel and its circulation and use among the South Slavs.U ovom se članku objavljuje Knjiga o Danijelu (poglavlja 1-5,4) iz starog brevijara Vida Omišljanina u latiničnoj transliteraciji. Ovaj brevijar iz 1396. jedini je hrvatski glagoljski brevijar koji ima četiri poglavlja te biblijske knjige. Ona kombinira razne tekstualne slojeve: 1) rani prijevod Parimejnika (Prophetologiona) za koji se smatra da je nastao iz grčkoga još u ćirilometodskom razdoblju; 2) takozvanu simeonovsku potpunu inačicu (najvjerojatnije komentiranu) nastalu u vremenu Prvoga bugarskog carstva u sjeveroistočnim bugarskim zemljama prema drugačijem grčkom izvorniku i 3) novi sloj koji odražava prijevod s latinskog i/ili redakciju prema latinskom izvorniku (Vulgati) koje su napravili hrvatski glagoljaši. Prema tome bi ovo izdanje Knjige Danijelove iz Brevijara Vida Omišljanina moglo poslužiti kao osnova za daljnji studij tekstualne povijesti Knjige o Danijelu i njezina kruženja i uporabe među južnim Slavenima

Исторически маршрути. Българската протодържава - Екзархията и Търновската конституция

Под формата на виртуален културно-исторически маршрут в настоящата статия се представят две исторически теми. Едната е свързана с първото мащабно и организирано българско политическо движение през ХІХ в. – борбите за самостоятелна църква и създаването на Българската екзархия. Втората тема е свикването и работата на Учредителното събрание в Търново през 1879 г., приело първата Конституция на Княжество България. В изложението е показана и връзката между създадената през 70-те години на ХІХ в. българска протодържава – Екзархията и новата българска държава, основа на която е Търновската конституция от 16 април 1879 г.In the form of a virtual cultural-historical route, this article presents two historical topics. One is related to the first large-scale and organized Bulgarian political movement in the nineteenth century - the struggle for an independent church and the creation of the Bulgarian Exarchate. The second topic is the convening and work of the Constituent Assembly in Tarnovo in 1879, which adopted the first Constitution of the Principality of Bulgaria. The exhibition also shows the connection between the Bulgarian proto-state established in the 1870s - the Exarchate and the new Bulgarian state, based on the Tarnovo Constitution of April 16, 1879

Laser milling : surface integrity, removal strategies and process accuracy

Laser milling is capable of processing a large range of materials which are not machinable with conventional manufacturing processes. Engineering materials such as glass, metals and ceramics can be machined without requiring expensive special tools and without any limitations on the 3D complexity of the component. Laser milling is still in its infancy. Laser material interactions are not yet fully understood. Much effort in research and development of the available laser sources is still needed. Ultrafast lasers are beginning to be applied. They can offer more precise machining without the thermal damage that accompanies long-pulse laser manufacturing. Laser pulse duration and its effect on resulting surface integrity has been studied as well as material removal strategy and process accuracy. In order to characterise the resulting surface after laser ablation, the heat affected zone is usually specified. In most cases, visual inspection would be performed without further analysis, resulting in variance of the findings attributed to the operator. A new methodology was required to accurately and impartially assess the heat penetration and quantify the findings. Based on material grain refinement, a comprehensive new methodology was created. By monitoring the changes in grain sizes, a chart of the heat penetration could be created accurately with automated routines. Surface integrity is a critical factor for many applications and a methodology based on analysis of grain refinement in the vicinity of the processed area would create a full map of - iii - the changes happening after laser ablation. Furthermore, the impact of the laser pulse duration is studied utilising the above mentioned development. Further to the surface roughness and heat affected zone, an in-depth analysis was completed on the micro hardness of the material in order to create a comprehensive chart of the changes induced by the laser milling process. Material removal is based on the overlapping of single craters, and the way the craters overlap is referred to as material removal strategy. Generally there are many strategies formulated for material removal but none of them takes into account the specifics of laser milling. Based on surface orientation, dimensions and feature importance, an assessment of material removal strategies is presented. Although ‘laser milling’ is a term used for a number of material removal processes, there are significant differences between them. New strategies for material removal are formulated and reported based on surface topography and orientation. Advanced programming is realised using a commercially available generic CAM package but taking into account the specifics of the laser milling process. The accuracy of the laser milling process depends on the laser-material interaction, and also on the machine hardware, control system and software. Most of the factors affecting accuracy cannot be changed once the machine is built, but there are some that can be optimised to improve process accuracy. The laser source with its characteristics is as important as the material being processed. The relationship between pulse duration, pulse shape and accuracy of the process was demonstrated through a series of experiments designed to expose the correlation between, and impact of, these parameters.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Trovanje antikoagulantnim rodenticidom bromadiolonom u psa - prikaz slučaja

A spontaneous intoxication caused by the anticoagulant rodenticide bromadiolone (Lanirat 0.005) in a Caucasian mountain shepherd dog at the age of 18 months is described. During its hospitalization at the Clinic of Internal Diseases, Faculty of Veterinary Medicine in Stara Zagora, clinical, laboratory, microbiological, radiological and ultrasonographic studies were performed. It was found that rodenticide intoxication was manifested by changes in the clinical status (arexia, polydipsia, hyperthermia, polypnea, dyspnea, tachycardia, pale conjunctives, liquidothorax and ascites) and in studied laboratory parameters (oligochromaemia, erythropenia, leukocytosis with neutrophilia and regenerative shift, hyperglycaemia, increased ALAT activities and prolonged PT, APTT and PIVKA).Opisano je trovanje antikoagulantnim rodenticidom bromadiolonom (Lanirat 0,005) u kavkaskog planinskog ovčara u dobi 18 mjeseci. U tijeku njegova liječenja provedene su kliničke, laboratorijske, mikrobiološke, radiološke i ultrazvučne pretrage. Trovanje se očitovalo promjenama u kliničkoj slici (areksija, polidipsija, hipertermija, polipneja, dispneja, tahikardija, bljedoća spojnica, likvidotoraks i ascites). Od laboratorijskih pokazatelja ustanovljena je oligokromemija, eritropenija, leukocitoza s neutrofilijom i regenerativnim promjenama, hiperglikemija, povećana aktivnost ALAT i produženo PT, APTT i PIVKA

Laser milling: surface integrity, removal strategies and process accuracy

Laser milling is capable of processing a large range of materials which are not machinable with conventional manufacturing processes. Engineering materials such as glass, metals and ceramics can be machined without requiring expensive special tools and without any limitations on the 3D complexity of the component. Laser milling is still in its infancy. Laser material interactions are not yet fully understood. Much effort in research and development of the available laser sources is still needed. Ultrafast lasers are beginning to be applied. They can offer more precise machining without the thermal damage that accompanies long-pulse laser manufacturing. Laser pulse duration and its effect on resulting surface integrity has been studied as well as material removal strategy and process accuracy. In order to characterise the resulting surface after laser ablation, the heat affected zone is usually specified. In most cases, visual inspection would be performed without further analysis, resulting in variance of the findings attributed to the operator. A new methodology was required to accurately and impartially assess the heat penetration and quantify the findings. Based on material grain refinement, a comprehensive new methodology was created. By monitoring the changes in grain sizes, a chart of the heat penetration could be created accurately with automated routines. Surface integrity is a critical factor for many applications and a methodology based on analysis of grain refinement in the vicinity of the processed area would create a full map of - iii - the changes happening after laser ablation. Furthermore, the impact of the laser pulse duration is studied utilising the above mentioned development. Further to the surface roughness and heat affected zone, an in-depth analysis was completed on the micro hardness of the material in order to create a comprehensive chart of the changes induced by the laser milling process. Material removal is based on the overlapping of single craters, and the way the craters overlap is referred to as material removal strategy. Generally there are many strategies formulated for material removal but none of them takes into account the specifics of laser milling. Based on surface orientation, dimensions and feature importance, an assessment of material removal strategies is presented. Although ‘laser milling’ is a term used for a number of material removal processes, there are significant differences between them. New strategies for material removal are formulated and reported based on surface topography and orientation. Advanced programming is realised using a commercially available generic CAM package but taking into account the specifics of the laser milling process. The accuracy of the laser milling process depends on the laser-material interaction, and also on the machine hardware, control system and software. Most of the factors affecting accuracy cannot be changed once the machine is built, but there are some that can be optimised to improve process accuracy. The laser source with its characteristics is as important as the material being processed. The relationship between pulse duration, pulse shape and accuracy of the process was demonstrated through a series of experiments designed to expose the correlation between, and impact of, these parameters

CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse.

In most mammals, including mice and humans, meiotic recombination is determined by the meiosis specific histone methytransferase PRDM9, which binds to specific DNA sequences and trimethylates histone 3 at lysine-4 and lysine-36 at the adjacent nucleosomes. These actions ensure successful DNA double strand break formation and repair that occur on the proteinaceous structure forming the chromosome axis. The process of hotspot association with the axis after their activation by PRDM9 is poorly understood. Previously, we and others have identified CXXC1, an ortholog of S. cerevisiae Spp1 in mammals, as a PRDM9 interactor. In yeast, Spp1 is a histone methyl reader that links H3K4me3 sites with the recombination machinery, promoting DSB formation. Here, we investigated whether CXXC1 has a similar function in mouse meiosis. We created two Cxxc1 conditional knockout mouse models to deplete CXXC1 generally in germ cells, and before the onset of meiosis. Surprisingly, male knockout mice were fertile, and the loss of CXXC1 in spermatocytes had no effect on PRDM9 hotspot trimethylation, double strand break formation or repair. Our results demonstrate that CXXC1 is not an essential link between PRDM9-activated recombination hotspot sites and DSB machinery and that the hotspot recognition pathway in mouse is independent of CXXC1

Knjiga o Danijelu u Brevijaru Vida Omišljanina

An edition of the Book of Daniel (chapters 1-5:4) in the archaic Breviary of Vid of Omišalj with the Latin transliteration is published in the paper. This breviary (1396) is the only Croato-Glagolitic manuscript that contains four chapters of this biblical book. It combines different textual layers: 1) the early Parimijnik (Prophetologion) translation which is supposed to have been made from Greek already in the Cyrillo-Methodian period; 2) the so-called Symeonic complete version (most probably a commentated one) produced in the period of the First Bulgarian Kingdom in Northeastern Bulgarian lands against a different Greek original; and 3) a new stratum reflecting a translation from and/or redaction against a Latin original (Vulgate) produced by Croatian glagoljaši. Therefore, the edition of the Book of Daniel in the Breviary of Vid of Omišalj could serve as a basis for further study of the textual history of the Book of Daniel and its circulation and use among the South Slavs.U ovom se članku objavljuje Knjiga o Danijelu (poglavlja 1-5,4) iz starog brevijara Vida Omišljanina u latiničnoj transliteraciji. Ovaj brevijar iz 1396. jedini je hrvatski glagoljski brevijar koji ima četiri poglavlja te biblijske knjige. Ona kombinira razne tekstualne slojeve: 1) rani prijevod Parimejnika (Prophetologiona) za koji se smatra da je nastao iz grčkoga još u ćirilometodskom razdoblju; 2) takozvanu simeonovsku potpunu inačicu (najvjerojatnije komentiranu) nastalu u vremenu Prvoga bugarskog carstva u sjeveroistočnim bugarskim zemljama prema drugačijem grčkom izvorniku i 3) novi sloj koji odražava prijevod s latinskog i/ili redakciju prema latinskom izvorniku (Vulgati) koje su napravili hrvatski glagoljaši. Prema tome bi ovo izdanje Knjige Danijelove iz Brevijara Vida Omišljanina moglo poslužiti kao osnova za daljnji studij tekstualne povijesti Knjige o Danijelu i njezina kruženja i uporabe među južnim Slavenima

Evaluation of Numerical Methods for Discrete-Time H∞ Optimization

We compare the numerical properties of the different numerical methods for solving the H-infinity optimization problems for linear discrete-time systems. It is shown that the methods based on the solution of the associated discrete-time algebraic Riccati equation may be unstable due to an unnecessary increase in the condition number and that they have restricted application for ill-conditioned and singular problems. The experiments confirm that the numerical solution methods that are based on the solution of a Linear Matrix Inequality (LMI) are a much more reliable although much more expensive numerical technique for solving H-infinity optimization problems. Directions for developing high-performance software for H-infinity optimization are discussed

A quantitative assay for crossover and noncrossover molecular events at individual recombination hotspots in both male and female gametes

AbstractMeiotic recombination is a fundamental process in all eukaryotes. Among organisms in which recombination initiates prior to synapsis, recombination preferentially occurs in short 1-to 2-kb regions, known as recombination hotspots. Among mammals, genotyping sperm DNA has provided a means of monitoring recombination events at specific hotspots in male meiosis. To complement these current techniques, we developed an assay for amplifying all copies of a hotspot from the DNA of male and female germ cells, cloning the products into Escherichia coli, and SNP genotyping the resulting colonies using fluorescence technology. This approach examines the molecular details of crossover and noncrossover events of individual meioses directly at active hotspots while retaining the simplicity of using pooled DNA. Using this technique, we analyzed recombination events at the Hlx1 hotspot located on mouse chromosome 1, finding that the results agree well with a prior genetic characterization of 3026 male and 3002 female meioses