Binge Eating Disorder Mediates Links between Symptoms of Depression and Anxiety and Caloric Intake in Obese Women

Despite considerable comorbidity between mood disorders, binge eating disorder (BED), and obesity, the underlying mechanisms remain unresolved. Therefore, the purpose of this study was to examine models by which internalizing behaviors of depression and anxiety influence food intake in overweight/obese women. Thirty-two women (15 BED, 17 controls) participated in a laboratory eating-episode and completed questionnaires assessing symptoms of anxiety and depression. Path analysis was used to test mediation and moderation models to determine the mechanisms by which internalizing symptoms influenced kilocalorie (kcal) intake. The BED group endorsed significantly more symptoms of depression (10.1 versus 4.8, P=0.005 ) and anxiety (8.5 versus 2.7, P=0.003). Linear regression indicated that BED diagnosis and internalizing symptoms accounted for 30% of the variance in kcal intake. Results from path analysis suggested that BED mediates the influence of internalizing symptoms on total kcal intake. The associations between internalizing symptoms and food intake are best described as operating indirectly through a BED diagnosis. This suggests that symptoms of depression and anxiety influence whether one engages in binge eating, which influences kcal intake. Greater understanding of the mechanisms underlying the associations between mood, binge eating, and food intake will facilitate the development of more effective prevention and treatment strategies for both BED and obesity

Diagnostics of the structure of AGN's broad line regions with reverberation mapping data: confirmation of the two-component broad line region model

We re-examine the ten Reverberation Mapping (RM) sources with public data based on the two-component model of the Broad Line Region (BLR). In fitting their broad H-beta lines, six of them only need one Gaussian component, one of them has a double-peak profile, one has an irregular profile, and only two of them need two components, i.e., a Very Broad Gaussian Component (VBGC) and an Inter-Mediate Gaussian Component (IMGC). The Gaussian components are assumed to come from two distinct regions in the two-component model; they are Very Broad Line Region (VBLR) and Inter-Mediate Line region (IMLR). The two sources with a two-component profile are Mrk 509 and NGC 4051. The time lags of the two components of both sources satisfy $t_{IMLR}/t_{VBLR}=V^2_{VBLR}/V^2_{IMLR}$, where $t_{IMLR}$ and $t_{VBLR}$ are the lags of the two components while $V_{IMLR}$ and $V_{VBLR}$ represent the mean gas velocities of the two regions, supporting the two-component model of the BLR of Active Galactic Nuclei (AGN). The fact that most of these ten sources only have the VBGC confirms the assumption that RM mainly measures the radius of the VBLR; consequently, the radius obtained from the R-L relationship mainly represent the radius of VBLR. Moreover, NGC 4051, with a lag of about 5 days in the one component model, is an outlier on the R-L relationship as shown in Kaspi et al. (2005); however this problem disappears in our two-component model with lags of about 2 and 6 days for the VBGC and IMGC, respectively.Comment: 7 pages, 5 figures. Accepted for publication in the Special Issue of Science in China (G) "Astrophysics of Black holes and Related Compact Objects

Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct

We tested whether severe congestive heart failure (CHF), a condition associated with excess free-water retention, is accompanied by altered regulation of the vasopressin-regulated water channel, aquaporin-2 (AQP2), in the renal collecting duct. CHF was induced by left coronary artery ligation. Compared with sham-operated animals, rats with CHF had severe heart failure with elevated left ventricular end-diastolic pressures (LVEDP): 26.9 ± 3.4 vs. 4.1 ± 0.3 mmHg, and reduced plasma sodium concentrations (142.2 ± 1.6 vs. 149.1 ± 1.1 mEq/liter). Quantitative immunoblotting of total kidney membrane fractions revealed a significant increase in AQP2 expression in animals with CHF (267 ± 53%, n=12) relative to sham-operated controls (100 ± 13%, n=14). In contrast, immunoblotting demonstrated a lack of an increase in expression of AQP1 and AQP3 water channel expression, indicating that the effect on AQP2 was selective.Furthermore, postinfarction animals without LVEDP elevation or plasma Na reduction showed no increase in AQP2 expression (121 ± 28% of sham levels, n=6). Immunocytochemistry and immunoelectron microscopy demonstrated very abundant labeling of the apical plasma membrane and relatively little labeling of intracellular vesicles in collecting duct cells from rats with severe CHF, consistent with enhanced trafficking of AQP2 to the apical plasma membrane. The selective increase in AQP2 expression and enhanced plasma membrane targeting provide an explanation for the development of water retention and hyponatremia in severe CHF

Active Galaxies and Cluster Gas

Two lines of evidence indicate that active galaxies, principally radio galaxies, have heated the diffuse hot gas in clusters. The first is the general need for additional heating to explain the steepness of the X-ray luminosity--temperature relation in clusters, the second is to solve the cooling flow problem in cluster cores. The inner core of many clusters is radiating energy as X-rays on a timescale much shorter than its likely age. Although the temperature in this region drops by a factor of about 3 from that of the surrounding gas, little evidence is found for gas much cooler than that. Some form of heating appears to be taking place, probably by energy transported outward from the central accreting black hole or radio source. How that energy heats the gas depends on poorly understood transport properties (conductivity and viscosity) of the intracluster medium. Viscous heating is discussed as a possibility. Such heating processes have consequences for the truncation of the luminosity function of massive galaxies.Comment: 14 pages, 16 fig, Feb 2004 talk for Phil Trans Roy So

The Plants Database: Providing Basic Plant Information

The PLANTS database provides basic plant information to the United States Department of Agriculture (USDA), Natural Resources Conservation Service (NRCS), its clients, cooperators, and the general public via the World Wide Web (Fig. 1). The foundation of PLANTS is a taxonomic backbone (checklist) of the vascular and nonvascular plants of North America (north of Mexico) and United States territories in the Caribbean and Pacific regions. Attribute data are appended to this backbone pertaining to distribution, vegetative specifications, nativity, federal and state status, crop data, growth form, growth parameters, species abstracts, and images

First Results from SPARO: Evidence for Large-Scale Toroidal Magnetic Fields in the Galactic Center

We have observed the linear polarization of 450 micron continuum emission from the Galactic center, using a new polarimetric detector system that is operated on a 2 m telescope at the South Pole. The resulting polarization map extends ~ 170 pc along the Galactic plane and ~ 30 pc in Galactic latitude, and thus covers a significant fraction of the central molecular zone. Our map shows that this region is permeated by large-scale toroidal magnetic fields. We consider our results together with radio observations that show evidence for poloidal fields in the Galactic center, and with Faraday rotation observations. We compare all of these observations with the predictions of a magnetodynamic model for the Galactic center that was proposed in order to explain the Galactic Center Radio Lobe as a magnetically driven gas outflow. We conclude that the observations are basically consistent with the model.Comment: 11 pages, 2 figures, 1 table, submitted to ApJ Let