30,242 research outputs found

    Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction

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    A. Burri, Q. Rahman and T. Spector (2011). Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction. Psychological Medicine, 41, pp 2435-2445. Copyright © Cambridge University Press 2011. http://dx.doi.org/10.1017/S003329171100049

    Simulated rotor test apparatus dynamic characteristics in the 80- by 120-foot wind tunnel

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    A shake test was conducted in the 80 by 120 foot Wind Tunnel at NASA Ames Research Center, using a load frame and dummy weights to simulate the weight of the NASA Rotor Test Apparatus. The simulated hub was excited with broadband random excitation, and accelerometer responses were measured at various locations. The transfer functions (acceleration per unit excitation force as a function of frequency) for each of the accelerometer responses were computed, and the data were analyzed using modal analysis to estimate the model parameters

    Development of thermally stable phosphonitrile elastomers for advanced aerospace structures

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    Both high and low molecular weight, curable poly(fluoroalkoxy phosphazene) terpolymers were prepared. These terpolymers resulted from reaction of (Cl2PNn) polymer with alkoxides derived from CF3CH2OH and C3F7CH2OH, and an alkoxide derived from CH3CH(OH)C2H4OH. The terpolymers were crosslinked with polyisocyanates at room temperature. High molecular weight materials were converted into isocyanate prepolymers which as films underwent moisture cures at room temperature. Prepolymer solutions were stable for several days, and showed good adhesion. Also the effects of polymerization of (Cl2PN)3 were studied. Purified octachlorophosphazene, thiocyanate salts, or hydrogen chloride were employed in attempts to decrease molecular weight. Hydrogen chloride was found to be a good agent for preparation of low molecular weight poly(dichloro phosphazene)

    Strong Optomechanical Squeezing of Light

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    We create squeezed light by exploiting the quantum nature of the mechanical interaction between laser light and a membrane mechanical resonator embedded in an optical cavity. The radiation pressure shot noise (fluctuating optical force from quantum laser amplitude noise) induces resonator motion well above that of thermally driven motion. This motion imprints a phase shift on the laser light, hence correlating the amplitude and phase noise, a consequence of which is optical squeezing. We experimentally demonstrate strong and continuous optomechanical squeezing of 1.7 +/- 0.2 dB below the shot noise level. The peak level of squeezing measured near the mechanical resonance is well described by a model whose parameters are independently calibrated and that includes thermal motion of the membrane with no other classical noise sources.Comment: 12 pages, 8 figure

    Zebrafish-Based Small Molecule Discovery

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    AbstractThe earliest examples of small molecule discovery involved serendipitous phenotypic observations in whole organisms, but this organism-based process has given way in recent decades to systematic, high-throughput assays using purified proteins, cells, or cell extracts. In vitro screens have been successful at identifying modifiers of well-understood biological processes, but they are limited in their ability to discover modifiers of processes that are poorly understood or occur only in an integrated physiological context. Small model organisms, especially the zebrafish, make it possible to combine the advantages of organism-based small molecule discovery with the technologies and throughput of modern screening. The combination of model organisms with high-throughput screening is likely to extend small molecule discovery efforts to fields of study such as developmental biology and to broaden the range of diseases for which drug screening can be performed
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