A Framework for the International Polar Year, 2007-2008

The polar regions are integral components of the Earth system. As the heat sinks of the climate system they both respond to and drive changes elsewhere on the planet. Within them lie frontiers of knowledge as well as unique vantage points for science. Yet because of their remoteness and harsh nature, the poles remain insufficiently studied. With recent technological advances providing new scientific possibilities, and humankind‘s need for environmental knowledge and understanding ever increasing, the time is ripe for a coordinated international initiative to achieve a major advance in polar science. For this reason, the International Council for Science (ICSU) decided to take the lead in organizing an International Polar Year (IPY) in 2007-2008. They did so by establishing an IPY Planning Group (PG) charged with developing the IPY 2007-2008 science plan and implementation strategy. This report is the outcome of the PG‘s work. It is based on input from individuals, from over 40 governmental and nongovernmental organizations that have endorsed or expressed support for IPY 2007-2008, and from the 32 IPY National Committees or National Points of Contact established so far. It is also results from discussions and debate at over a dozen international meetings covering the gamut of science disciplines, from a series of "town" meetings, and from two Discussion Forums hosted by ICSU and attended by representatives of the IPY National Committees and a variety of interested polar organizations

The Sign of the V: Papers in Honour of Sten Vikner

‘The Sign of the V’ is a festschrift in honour of Sten Vikner, written by friends, colleagues, and collaborators, present and past, to celebrate both his 60th birthday and his contribution to the field of linguistics. The papers cover a wide range of topics in theoretical and empirical linguistic research, from phonetics and phonology, through morphology, semantics, and syntax, to pragmatics, as well as language acquisition, second-language learning, language processing, language teaching, language contact, historical linguistics, and language variation and change. Many different languages are featured, including the Scandinavian languages (i.e. Danish, Faroese, Icelandic, Norwegian and Swedish), Catalan, Dutch, English, Finnish, West Flemish, French, German, Greek, Italian, Scots, and Yiddish. The scope and depth of the chapters in this anthology is a clear indication of the scope and depth of Sten Vikner’s own comparative research well as his impact on the field of linguistics.‘The Sign of the V’ is a festschrift in honour of Sten Vikner, written by friends, colleagues, and collaborators, present and past, to celebrate both his 60th birthday and his contribution to the field of linguistics. The papers cover a wide range of topics in theoretical and empirical linguistic research, from phonetics and phonology, through morphology, semantics, and syntax, to pragmatics, as well as language acquisition, second-language learning, language processing, language teaching, language contact, historical linguistics, and language variation and change. Many different languages are featured, including the Scandinavian languages (i.e. Danish, Faroese, Icelandic, Norwegian and Swedish), Catalan, Dutch, English, Finnish, West Flemish, French, German, Greek, Italian, Scots, and Yiddish. The scope and depth of the chapters in this anthology is a clear indication of the scope and depth of Sten Vikner’s own comparative research well as his impact on the field of linguistics

The Sign of the V: Papers in Honour of Sten Vikner

‘The Sign of the V’ is a festschrift in honour of Sten Vikner, written by friends, colleagues, and collaborators, present and past, to celebrate both his 60th birthday and his contribution to the field of linguistics. The papers cover a wide range of topics in theoretical and empirical linguistic research, from phonetics and phonology, through morphology, semantics, and syntax, to pragmatics, as well as language acquisition, second-language learning, language processing, language teaching, language contact, historical linguistics, and language variation and change. Many different languages are featured, including the Scandinavian languages (i.e. Danish, Faroese, Icelandic, Norwegian and Swedish), Catalan, Dutch, English, Finnish, West Flemish, French, German, Greek, Italian, Scots, and Yiddish. The scope and depth of the chapters in this anthology is a clear indication of the scope and depth of Sten Vikner’s own comparative research well as his impact on the field of linguistics.‘The Sign of the V’ is a festschrift in honour of Sten Vikner, written by friends, colleagues, and collaborators, present and past, to celebrate both his 60th birthday and his contribution to the field of linguistics. The papers cover a wide range of topics in theoretical and empirical linguistic research, from phonetics and phonology, through morphology, semantics, and syntax, to pragmatics, as well as language acquisition, second-language learning, language processing, language teaching, language contact, historical linguistics, and language variation and change. Many different languages are featured, including the Scandinavian languages (i.e. Danish, Faroese, Icelandic, Norwegian and Swedish), Catalan, Dutch, English, Finnish, West Flemish, French, German, Greek, Italian, Scots, and Yiddish. The scope and depth of the chapters in this anthology is a clear indication of the scope and depth of Sten Vikner’s own comparative research well as his impact on the field of linguistics

Anmeldelse: Kampen om evidens

Anmeldelse af "Kampen om evidens

Are human endogenous retroviruses triggers of autoimmune diseases? Unveiling associations of three diseases and viral loci

Autoimmune diseases encompass a plethora of conditions in which the immune system attacks its own tissue, identifying them as foreign. Multiple factors are thought to contribute to the development of immune response to self, including differences in genotypes, hormonal milieu, and environmental factors. Viruses including human endogenous retroviruses have long been linked to the occurrence of autoimmunity, but never proven to be causative factors. Endogenous viruses are retroviral sequences embedded in the host germline DNA and transmitted vertically through successive generations in a Mendelian manner. In this study by means of genetic epidemiology, we have searched for the involvement of endogenous retroviruses in three selected autoimmune diseases: multiple sclerosis, type 1 diabetes mellitus, and rheumatoid arthritis. We found that at least one human endogenous retroviral locus was associated with each of the three diseases. Although there was a significant overlap, most loci only occurred in one of the studied disease. Remarkably, within each disease, there was a statistical interaction (synergy) between two loci. Additional synergy between retroviral loci and human lymphocyte antigens is reported for multiple sclerosis. We speculate the possibility that recombinants or mixed viral particles are formed and that the resulting viruses stimulate the innate immune system, thereby initiating the autoimmune response. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12026-015-8671-z) contains supplementary material, which is available to authorized users