The Formation of Morpholine Thiosulfate From Morpholine and Sulfur

In recent years the use of morpholine and sulfur in the Willgerodt reaction has received considerable attention. There have been several mechanisms proposed for the Willgerodt reaction, but the most generally accepted mechanism today is that outlined by King and McMillan1. These authors have attempted to show that an independent reaction between sulfur and the amine is essential to this reaction. They have postulated an amine sulfide intermediate similar to the already known amine oxides. These sulfides have not been isolated as by-products of the reaction nor have they been prepared in any other way. The only previous evidence of a reaction between sulfur and morpholine is the formation of dithiooxalodi-morpholide reported by Horton and Van den Berghe2

FINANCIAL RISK AND FINANCIAL RISK MANAGEMENT TECHNOLOGY (RMT): ISSUES AND ADVANTAGES

Methods for sound risk management are of increasing interest among Wall Street investment banking and brokerage firms in the aftermath of the October 1987 crash of the stock market. As the knowledge of advanced technology applications in risk management increases, financial firms are finding innovative ways to use them practically, in order to insulate themselves. The recent development in models, the software and hardware, and the market data to track risk are all considered advances in Risk Management Technology (RMT). These advances have affected all three stages of risk management: the identification, the measurement, and the formulation of strategies to control financial risk. This article discusses the advances made in five areas of RMT: communication software, object-oriented programming, parallel processing, neural nets and artificial intelligence. Systems based on any of these areas may be used to add value to the business of a firm. A business value linkage analysis shows how the utility of advanced systems can be measured to justify their costs.Information Systems Working Papers Serie

FINANCIAL RISK AND FINANCIAL RISK MANAGEMENT TECHNOLOGY (RMT): ISSUES AND ADVANCES

Methods for sound risk management are of increasing interest among Wall Street investment banking and brokerage firms in the aftermath of the October 1987 crash of the stock market. We present an overview of the basic definitions and issues related to risk, and the management of financial risk and financial risk management technology (RMT) for information systems (IS) technology professionals. We discuss of the content of risk management technology, including the models, the software and hardware, and the market data required to track risk. We also discuss the identification of risky events, alternative approaches to the measurement of risk, and how investment firms go about formulating strategies to control financial risk. We next show how changes in the information technologies supporting these tasks have led to improvements in the control of risk and in the design of products which involve financial risk. Advances in five areas that are of interest are: communications software, object-oriented programming, the use of parallel processors and supercomputers, and the application of artificial intelligence and neural nets. Although these new information technologies create significant opportunities to improve global and departmental risk management, a basic question that must be addressed involves the costs associated with their implementation. Thus, a third contribution of this paper is to analyze the extent to which the implementation of these technologies will affect firm costs. To this end, we evaluate the components of the cost function for risk management, and consider some ways that the new technologies can be applied to reduce overall costs.Information Systems Working Papers Serie

APPLICATIONS: Financial risk and financial Risk Management Technology (RMT): Issues and advances

Methods for sound risk management are of increasing interest among Wall Street investment banking and brokerage firms in the aftermath of the October 1987 crash of the stock market. As the knowledge of advanced technology applications in risk management increases, financial firms are finding innovative ways to use them practically, in order to insulate themselves. The recent development in models, the software and hardware, and the market data to track risk are all considered advances in Risk Management Technology (RMT). -. These advances have affected all three stages of risk management: the identification, the measurement, and the formulation of strategies to control financial risk. This article discusses the advances made in five areas of RMT: communication software, object-oriented programming, parallel processing, neural nets and artificial intelligence. Systems based on any of these areas may be used to add value to the business of a firm. A business value linkage analysis shows how the utility of advanced systems can be measured to justify their costs.Information Systems Working Papers Serie

Book Reviews

Book reviews by Roger Paul Peters, David Bidney, Lester M. Ponder, Edward J. Murphy, Thomas M. Clusserath, and Thomas L. Shaffer

Book Reviews

Book reviews by Julius Cohen, Edward F. Barrett, Roger P. Peters, Thomas M. Scanlon, and Clarence Manion

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism. O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells. Blocking glycosylation of PFK1 at serine 529 reduced cancer cell proliferation in vitro and impaired tumor formation in vivo. These studies reveal a previously uncharacterized mechanism for the regulation of metabolic pathways in cancer and a possible target for therapeutic intervention