Distribution of happiness ratings in three symptom severity subgroups (N = 2411).

<p>Normal/Mild subgroup: mean (sd) = 7.3 (1.2), range 1–10; Moderate subgroup: mean (sd) = 5.7 (1.8), range 0–9; Severe subgroup: mean (sd) = 4.2 (2.2), range 0–9.</p

Multivariable regression analysis predicting wellbeing from symptoms, personal resources, and the interaction between symptoms and resources (n = 2411).

<p>Multivariable regression analysis predicting wellbeing from symptoms, personal resources, and the interaction between symptoms and resources (n = 2411).</p

Additional file 2: of Decomposing the heterogeneity of depression at the person-, symptom-, and time-level: latent variable models versus multimode principal component analysis

A pdf file containing the R script for the presented multiway principle component analysis. (PDF 25 kb

Three-way Analysis of Variance after subtraction of the grand mean, with the patient-, symptom- and time-components as fixed factors.

<p>Note. <i>SS</i> = Sum of Squares. All effects and standard deviations (s.d.) averaged across 20 imputed datasets.</p

A. Examples of the mean BDI item score trajectories (‘general trend’), B. Examples of five patients’ individual BDI trajectories, C. Cognitive symptom-component plot around the general trend and D. Somatic-affective symptom-component plot around the general trend for the three person-mode components.

<p>The two vertical lines in panels 3 and 4 indicate the divisions between the two time-components (improving and persisting).</p

Crude and adjusted regression coefficients (B) for mental quality of life with general and abdominal obesity categories stratified by major depression/anxiety.

<p>Crude and adjusted regression coefficients (B) for mental quality of life with general and abdominal obesity categories stratified by major depression/anxiety.</p

Pearson correlations between the person-mode component scores and baseline variables.

<p>SCL-90 = Symptoms Checklist-90; MOS-SF36 = Medical Outcome Study Short Form 36; NEO-FFI = Neuroticism, Extraversion, Openness Five-Factor Inventory. All correlations had standard deviations (computed across 20 imputed datasets) <0.01. Non-significant correlations (<i>p</i>>0.05) are presented in parentheses. Correlation-coefficients that ≥0.3 in the absolute sense are printed in bold font; correlation coefficients ≥0.4 are underlined and printed in bold font.</p

Health-related quality of life (HR-QoL) domains in participants by BMI categories and MDD and/or anxiety disorders: deviation with standard error from the mean for normal weight participants.

<p>Health-related quality of life (HR-QoL) domains in participants by BMI categories and MDD and/or anxiety disorders: deviation with standard error from the mean for normal weight participants.</p

LifeLines cohort characteristics by BMI categories and abdominal obesity.

<p>LifeLines cohort characteristics by BMI categories and abdominal obesity.</p

The symptom-mode component scores averaged across 20 imputed data sets.

<p>Standard deviations (s.d.; computed across 20 imputed datasets) were at most 0.01 for all loadings. Component scores ≥0.20 are printed in bold font.</p