3,990 research outputs found
Ten Simple Rules for Reproducible Research in Jupyter Notebooks
Reproducibility of computational studies is a hallmark of scientific
methodology. It enables researchers to build with confidence on the methods and
findings of others, reuse and extend computational pipelines, and thereby drive
scientific progress. Since many experimental studies rely on computational
analyses, biologists need guidance on how to set up and document reproducible
data analyses or simulations.
In this paper, we address several questions about reproducibility. For
example, what are the technical and non-technical barriers to reproducible
computational studies? What opportunities and challenges do computational
notebooks offer to overcome some of these barriers? What tools are available
and how can they be used effectively?
We have developed a set of rules to serve as a guide to scientists with a
specific focus on computational notebook systems, such as Jupyter Notebooks,
which have become a tool of choice for many applications. Notebooks combine
detailed workflows with narrative text and visualization of results. Combined
with software repositories and open source licensing, notebooks are powerful
tools for transparent, collaborative, reproducible, and reusable data analyses
Chiral Estimates of Strong CP Violation Revisited
The effects of the CP violating term in the QCD Lagrangian upon low
energy hadronic phenomenology are reconsidered. Strong CP violating
interactions among Goldstone bosons and octet baryons are incorporated into an
effective chiral Lagrangian framework. The term's impact upon the
decays and is then investigated but
found to be extremely small. A refined model independent estimate of
nonanalytic contributions to the neutron electric dipole moment is also
determined using velocity dependent Baryon Chiral Perturbation Theory. We
obtain the approximate upper bound .Comment: 11 pages with 3 figures not included but available upon request,
CALT-68-184
The Effect of Air on Granular Size Separation in a Vibrated Granular Bed
Using high-speed video and magnetic resonance imaging (MRI) we study the
motion of a large sphere in a vertically vibrated bed of smaller grains. As
previously reported we find a non-monotonic density dependence of the rise and
sink time of the large sphere. We find that this density dependence is solely
due to air drag. We investigate in detail how the motion of the intruder sphere
is influenced by size of the background particles, initial vertical position in
the bed, ambient pressure and convection. We explain our results in the
framework of a simple model and find quantitative agreement in key aspects with
numerical simulations to the model equations.Comment: 14 pages, 16 figures, submitted to PRE, corrected typos, slight
change
Local multiresolution order in community detection
Community detection algorithms attempt to find the best clusters of nodes in
an arbitrary complex network. Multi-scale ("multiresolution") community
detection extends the problem to identify the best network scale(s) for these
clusters. The latter task is generally accomplished by analyzing community
stability simultaneously for all clusters in the network. In the current work,
we extend this general approach to define local multiresolution methods, which
enable the extraction of well-defined local communities even if the global
community structure is vaguely defined in an average sense. Toward this end, we
propose measures analogous to variation of information and normalized mutual
information that are used to quantitatively identify the best resolution(s) at
the community level based on correlations between clusters in
independently-solved systems. We demonstrate our method on two constructed
networks as well as a real network and draw inferences about local community
strength. Our approach is independent of the applied community detection
algorithm save for the inherent requirement that the method be able to identify
communities across different network scales, with appropriate changes to
account for how different resolutions are evaluated or defined in a particular
community detection method. It should, in principle, easily adapt to
alternative community comparison measures.Comment: 19 pages, 11 figure
Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin
Heart failure (HF)-associated anemia is common and has a poor outcome. Because bone marrow (BM) dysfunction may contribute to HF-associated anemia, we first investigated mechanisms of BM dysfunction in an established model of HF, the transgenic REN2 rat, which is characterized by severe hypertrophy and ventricular dilatation and SD rats as controls. Secondly, we investigated whether stimulation of hematopoiesis with erythropoietin (EPO) could restore anemia and BM dysfunction. After sacrifice, erythropoietic precursors (BFU-E) were isolated from the BM and cultured for 10 days. BFU-E were quantified and transcript abundance of genes involved in erythropoiesis were assayed. Number of BFU-E were severely decreased in BM of REN2 rats compared to SD rats (50 ± 6.2 vs. 6.4 ± 1.7, p < 0.01). EPO treatment increased hematocrit in the SD-EPO group (after 6 weeks, 49 ± 1 vs. 58 ± 1%, p < 0.01); however, in the mildly anemic REN2 rats, there was no effect (43 ± 1 vs. 44 ± 1%). This was paralleled by a 67% decrease in BFU-E in BM of REN2 rats compared to SD (p < 0.01). EPO significantly improved BFU-E in both SD and REN2 but could not restore this to control levels in the REN2 rats. Expression of several genes involved in differentiation (LMO2), mobilization (SDF-1), and iron incorporation (transferrin receptor) of the BM were differentially expressed in REN2 rats compared to SD rats, and EPO did not normalize this. Altogether, these results suggest that BM dysfunction is an important contributor to HF-associated anemia and that EPO is not an effective agent to treat HF-associated anemia
Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74029/1/j.1600-0625.2000.009003192.x.pd
Calculation of the Electron Self Energy for Low Nuclear Charge
We present a nonperturbative numerical evaluation of the one-photon electron
self energy for hydrogenlike ions with low nuclear charge numbers Z=1 to 5. Our
calculation for the 1S state has a numerical uncertainty of 0.8 Hz for hydrogen
and 13 Hz for singly-ionized helium. Resummation and convergence acceleration
techniques that reduce the computer time by about three orders of magnitude
were employed in the calculation. The numerical results are compared to results
based on known terms in the expansion of the self energy in powers of (Z
alpha).Comment: 10 pages, RevTeX, 2 figure
Bumpy black holes from spontaneous Lorentz violation
We consider black holes in Lorentz violating theories of massive gravity. We
argue that in these theories black hole solutions are no longer universal and
exhibit a large number of hairs. If they exist, these hairs probe the
singularity inside the black hole providing a window into quantum gravity. The
existence of these hairs can be tested by future gravitational wave
observatories. We generically expect that the effects we discuss will be larger
for the more massive black holes. In the simplest models the strength of the
hairs is controlled by the same parameter that sets the mass of the graviton
(tensor modes). Then the upper limit on this mass coming from the inferred
gravitational radiation emitted by binary pulsars implies that hairs are likely
to be suppressed for almost the entire mass range of the super-massive black
holes in the centers of galaxies.Comment: 40 pages, 4 figure
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