55 research outputs found
Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis : involvement of cyclooxygenases and heat shock protein 70
AIM: To determine whether ischemic preconditioning (IP) affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process. METHODS: In male Wistar rats, IP was performed by clamping of celiac artery (twice for 5 min at 5-min intervals). Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg). RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β. Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis. Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis. CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70
National Telemedicine Initiatives: Essential to Healthcare Reform
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78116/1/tmj.2009.9960.pd
Direct observation of Mg<sup>2+</sup> complexes in ionic liquid solutions by <sup>31</sup>Mg β-NMR spectroscopy
Current diagnostic and therapeutic management of patients with gastrointestinal stromal tumor (GIST)
Politics and Popular Opinion in East Germany, 1945-68. By Mark Allinson. Manchester. Eng.: Manchester University Press, 2000. Dist. St. Martin's Press, xii, 178 pp. Notes. Bibliography. Glossary. Index. Maps. $74.95, hard bound.
Sowjetjugend, 1917-1941: Generation zwischen Revolution und Resignation. Eds. Corinna Kuhr-Korolev, Stefan Plaggenborg, and Monica Wellmann. Essen: Klartext Verlag, 2001. 310 pp. Notes. Chronology. Glossary. DM 54.60, paper.
ZnIIand HgIIbinding to a designed peptide that accommodates different coordination geometries
A CueR fémszabályzó fehérjék fémkötő-doménjét utánzó peptidek kölcsönhatása átmenetifém-ionokkal
Epidermal growth factor accelerates pancreatic recovery after caerulein-induced pancreatitis
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