1 research outputs found
Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy
White adipose tissue inflammation
(WATi) has been linked to the
pathogenesis of obesity-related diseases, including type 2 diabetes,
cardiovascular disease, and cancer. In addition to the obese, a substantial
number of normal and overweight individuals harbor WATi, putting them
at increased risk for disease. We report the first technique that
has the potential to detect WATi noninvasively. Here, we used Raman
spectroscopy to detect WATi with excellent accuracy in both murine
and human tissues. This is a potentially significant advance over
current histopathological techniques for the detection of WATi, which
rely on tissue excision and, therefore, are not practical for assessing
disease risk in the absence of other identifying factors. Importantly,
we show that noninvasive Raman spectroscopy can diagnose WATi in mice.
Taken together, these results demonstrate the potential of Raman spectroscopy
to provide objective risk assessment for future cardiometabolic complications
in both normal weight and overweight/obese individuals