Genetic distances within HIV subtypes and CRFs.

<p>CRF, circulating recombinant forms.</p

Neighbor-joining tree of 18 HIV-2protease sequences; the prefix BF represents sequences recovered from Burkina Faso patients in 1986.

<p>For comparison, 7 1980s sequences from Ivory Coast were included in the tree and contain the prefixes IC. Highlighted sequences in gray were from mixed HIV-1/HIV-2 infections; the remainders were from monotypic HIV-2 infections; groups #1 and #2 within subtype A represent distinct subclusters of closely related sequences. Viruses from sooty mangabeys are shown (SIVsm). The position of the outgroup (SIV-cpz sequence) is not shown. The number on the node indicates the bootstrap value; only values 68% or greater are shown. The scale bar indicates an evolutionary distance of 0.1 nucleotides per site. Vertical distances are for clarity only.</p

Summary of distribution of HIV-1 (env gp41, PR) and HIV-2 (PR and INT) gene sequences.

<p>CRF, denotes circulating recombinant forms; * denotes gene regions where RT-PCR amplification was attempted; PR, protease; INT, denotes Integrase; gp41, envelope glycoprotein 41. Neg indicates no amplifiable PCR product.</p

Comparison of the calculated Botswana TDF2 screened cohort reference intervals with the reference intervals used in Botswana and other African countries.

<p>*Botswana Ministry of health Patient management system Roche Integra derived values.</p><p>**Botswana Ministry of health reference values using the Beckman coulter AU680 analyzer.</p

The comparison of calculated population biochemical reference values for participants screened (N = 1786; Females = 770 and Males = 1016) for the TDF2 Botswana study with DAIDS and BOTUSA site established ranges.

<p>The comparison of calculated population biochemical reference values for participants screened (N = 1786; Females = 770 and Males = 1016) for the TDF2 Botswana study with DAIDS and BOTUSA site established ranges.</p

The TDF2 Botswana PrEp lab reference values Consort diagram.

<p>The TDF2 Botswana PrEp lab reference values Consort diagram.</p

The calculated population biochemical reference values for participants screened (N = 1786; Females = 770 and Males = 1016) for the TDF2 Botswana study.

<p>Note:</p><p>*P-value is for the Wilcoxon rank-sum test for Females versus Males.</p