The natural language processing of radiology requests and reports of chest imaging:Comparing five transformer models’ multilabel classification and a proof-of-concept study

Background: Radiology requests and reports contain valuable information about diagnostic findings and indications, and transformer-based language models are promising for more accurate text classification. Methods: In a retrospective study, 2256 radiologist-annotated radiology requests (8 classes) and reports (10 classes) were divided into training and testing datasets (90% and 10%, respectively) and used to train 32 models. Performance metrics were compared by model type (LSTM, Bertje, RobBERT, BERT-clinical, BERT-multilingual, BERT-base), text length, data prevalence, and training strategy. The best models were used to predict the remaining 40,873 cases’ categories of the datasets of requests and reports. Results: The RobBERT model performed the best after 4000 training iterations, resulting in AUC values ranging from 0.808 [95% CI (0.757–0.859)] to 0.976 [95% CI (0.956–0.996)] for the requests and 0.746 [95% CI (0.689–0.802)] to 1.0 [95% CI (1.0–1.0)] for the reports. The AUC for the classification of normal reports was 0.95 [95% CI (0.922–0.979)]. The predicted data demonstrated variability of both diagnostic yield for various request classes and request patterns related to COVID-19 hospital admission data. Conclusion: Transformer-based natural language processing is feasible for the multilabel classification of chest imaging request and report items. Diagnostic yield varies with the information in the requests

VeLight:A 3D virtual reality tool for CT-based anatomy teaching and training

Abstract: For doctors and other medical professionals, the human body is the focus of their daily practice. A solid understanding of how it is built up, that is, the anatomy of the human body, is essential to ensure safe medical practice. Current anatomy education takes place either using text books or via dissecting human cadavers, with text books being the most traditional way to learn anatomy due to the cost of the alternatives. However, printed media offer only a 2D perception of a part of the human body. Although dissection of human cadavers can give a more direct observation and interaction with human bodies, it is extremely costly because of the need of preserving human bodies and maintaining dissection rooms. To solve this issue, we developed VeLight, a system with which students can learn anatomy based on CT datasets using a 3D Virtual Reality display (zSpace). VeLight offers simple and intuitive interactions, and allows teachers to design their own courses using their own material. The system offers an interactive, depth-perceptive learning experience and improves the learning process. We conducted an informal user study to validate the effectiveness of VeLight. The results show that participants were able to learn and remember how to work with VeLight very quickly. All participants reported enthusiasm for the potential of VeLight in the domain of medical education. Graphic Abstract: [Figure not available: see fulltext.

Automatic Pulmonary Nodule Detection in CT Scans Using Convolutional Neural Networks Based on Maximum Intensity Projection

Accurate pulmonary nodule detection is a crucial step in lung cancer screening. Computer-aided detection (CAD) systems are not routinely used by radiologists for pulmonary nodule detection in clinical practice despite their potential benefits. Maximum intensity projection (MIP) images improve the detection of pulmonary nodules in radiological evaluation with computed tomography (CT) scans. Inspired by the clinical methodology of radiologists, we aim to explore the feasibility of applying MIP images to improve the effectiveness of automatic lung nodule detection using convolutional neural networks (CNNs). We propose a CNN-based approach that takes MIP images of different slab thicknesses (5 mm, 10 mm, 15 mm) and 1 mm axial section slices as input. Such an approach augments the two-dimensional (2-D) CT slice images with more representative spatial information that helps discriminate nodules from vessels through their morphologies. Our proposed method achieves sensitivity of 92.67% with 1 false positive per scan and sensitivity of 94.19% with 2 false positives per scan for lung nodule detection on 888 scans in the LIDC-IDRI dataset. The use of thick MIP images helps the detection of small pulmonary nodules (3 mm-10 mm) and results in fewer false positives. Experimental results show that utilizing MIP images can increase the sensitivity and lower the number of false positives, which demonstrates the effectiveness and significance of the proposed MIP-based CNNs framework for automatic pulmonary nodule detection in CT scans. The proposed method also shows the potential that CNNs could gain benefits for nodule detection by combining the clinical procedure

Deep convolutional neural networks for multi-planar lung nodule detection:improvement in small nodule identification

Objective: In clinical practice, small lung nodules can be easily overlooked by radiologists. The paper aims to provide an efficient and accurate detection system for small lung nodules while keeping good performance for large nodules. Methods: We propose a multi-planar detection system using convolutional neural networks. The 2-D convolutional neural network model, U-net++, was trained by axial, coronal, and sagittal slices for the candidate detection task. All possible nodule candidates from the three different planes are combined. For false positive reduction, we apply 3-D multi-scale dense convolutional neural networks to efficiently remove false positive candidates. We use the public LIDC-IDRI dataset which includes 888 CT scans with 1186 nodules annotated by four radiologists. Results: After ten-fold cross-validation, our proposed system achieves a sensitivity of 94.2% with 1.0 false positive/scan and a sensitivity of 96.0% with 2.0 false positives/scan. Although it is difficult to detect small nodules (i.e. < 6 mm), our designed CAD system reaches a sensitivity of 93.4% (95.0%) of these small nodules at an overall false positive rate of 1.0 (2.0) false positives/scan. At the nodule candidate detection stage, results show that a multi-planar method is capable to detect more nodules compared to using a single plane. Conclusion: Our approach achieves good performance not only for small nodules, but also for large lesions on this dataset. This demonstrates the effectiveness and efficiency of our developed CAD system for lung nodule detection. Significance: The proposed system could provide support for radiologists on early detection of lung cancer