7 research outputs found
Health economic evaluations comparing insulin glargine with NPH insulin in patients with type 1 diabetes: a systematic review
Association Between Gout and All-Cause as well as Cardiovascular Mortality: A Systematic Review
Association Between Gout and All-Cause as well as Cardiovascular Mortality: A Systematic Review
# The Author(s) 2012. This article is published with open access at Springerlink.com Abstract Gout affects 1 % to 2 % of the population, and the prevalence is increasing due to changes in diet and the ageing of the population. Its development and risk factors have been explored frequently, and recommendations for the diagnosis and management of gout implemented. Nevertheless, there is a lack of knowledge regarding the long-term impact on gouty patients. This systematic review therefore evaluates the association between gout and all-cause as well as cardiovascular mortality. A systematic literature search was performed, and seven long-term studies were ultimately analyzed. Six of them used multivariate regressions to assess the adjusted mortality ratio in gouty patients with reference to patients without the disorder. Despite differences in study designs, study populations, and definitions of gout, the results were consistent: There was an independent association between gout and all-cause as well as cardiovascular mortality. Knowing that patients with gout are at risk emphasizes the need for adequate care. Keywords Gout. Mortality. All-cause mortality. Cardiovascular mortality. Systematic review. Association
The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis Valor da anĂĄlise do LCR para o diagnĂłstico diferencial de mielopatia associada ao HTLV-I e esclerose mĂșltipla
Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/ tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases.<br>Amostras de lĂquido cefalorraquidiano (LCR) e soro de 17 pacientes brasileiros com HAM/TSP, seis com esclerose mĂșltipla e seis com epilepsia idiopĂĄtica (controle nĂŁo-inflamatĂłrio) foram analisadas para a presença de anticorpos para os vĂrus do sarampo, rubĂ©ola, varicela zoster e herpes simples pelo mĂ©todo de ELISA. Todos os casos de HAM/TSP e esclerose mĂșltipla tinham resposta imune intratecal (IgG oligoclonal). Somente 1/17 casos de HAM/TSP apresentavam resposta imune poliespecifica intratecal para sarampo e rubĂ©ola. Anticorpos especĂficos para sarampo e rubeola (resposta MRZ) foram observados em todos os pacientes com esclerose mĂșltipla, mas nĂŁo nos controles com epilepsia idiopĂĄtica. A relevĂąncia das respostas poliespecifica e monoespecifica Ă© discutida para essas doenças neurolĂłgicas crĂŽnicas