Enhancing the dynamic range of deformable mirrors with compression bias

We report the design and testing of a compression-biased thermally-actuated deformable mirror that has a dynamic range larger than the limit imposed by pure-bending stress, negligible higher-order-mode scattering, and a linear defocus response and that is vacuum compatible. The optimum design principles for this class of actuator are described and a mirror with 370 mD dynamic range is demonstrated

Mid-IR laser for wavefront correction in gravitational wave detectors

The next-generation gravitational wave detectors aim to enhance our understanding of extreme phenomena in the Universe. The high-frequency sensitivity of these detectors will be maximized by injecting squeezed vacuum states into the detector. However, the performance advantages offered by squeezed state injection can be easily degraded by losses in the system. A significant source of loss is the mode mismatch between optical cavities within the interferometer. To overcome this issue, new actuators are required that can produce a highly spherical wavefront change, with minimal higher order aberrations, whist adding low phase noise to the incident beam

Ultra-sensitive wavefront measurement using a Hartmann sensor

We describe a Hartmann sensor with a sensitivity of λ /15,500 at λ= 820nm. We also demonstrate its application to the measurement of an ultra small change in wavefront and show that the result agrees with that expected to within λ/3,300.Aidan F. Brooks, Thu-Lan Kelly, Peter J. Veitch, and Jesper Munc

Microarray patch delivery of un-adjuvanted influenza vaccine induces potent and broad-spectrum immune responses in a phase I clinical trial

Microarray patches (MAPs) offer the possibility of improved vaccine thermostability and dose-sparing potential as well as the potential to be safer, more acceptable, easier to use and more cost-effective for the administration of vaccines than injection by needle and syringe. Here, we report a phase I trial (ACTRN12618000112268/ U1111-1207-3550) using the Vaxxas high-density MAP (HD-MAP) to deliver a monovalent influenza vaccine to evaluate the safety, tolerability, and immunogenicity of lower doses of influenza vaccine delivered by MAPs. To the best of our knowledge, this is the first study determining dose reduction potential using MAPs in humans. Monovalent, split inactivated influenza virus vaccine containing A/Singapore/GP1908/ 2015 [H1N1] haemagglutinin (HA) was delivered by MAP into the volar forearm or upper arm, or given intramuscularly (IM) once. Participants (20 per group) received HD-MAPs delivering doses of 15, 10, 5, 2.5 or 0 µg of HA or an IM injection of quadrivalent influenza vaccine (QIV). In two subgroups, skin biopsies were taken on days 1 (pre-vaccination) and 4 for analysis of the cellular composition from the HD-MAP application sites. All laboratory investigators were blind to treatment and participant allocation. The primary objectives of the study were safety and tolerability. Secondary objectives included immunogenicity and dose de-escalation assessments of the influenza vaccine delivered by HD-MAP. Both objectives were assessed for up to 60 days post-vaccination. Please click Download on the upper right corner to see the full abstract

Early changes in scores of chronic damage on transplant kidney protocol biopsies reflect donor characteristics, but not future graft function.

The amount of irreversible injury on renal allograft biopsy predicts function, but little is known about the early evolution of this damage. In a single-center cohort, we examined the relationship between donor-, recipient-, and transplantation-associated factors and change in a morphometric index of chronic damage (ICD) between protocol biopsies performed at implantation and at 2-3 months. We then investigated whether early delta ICD predicted subsequent biochemical outcomes. We found little evidence to support differences between the study group, who had undergone serial biopsies, and a contemporaneous control group, who had not. In allografts with serial biopsies (n = 162), there was an increase in ICD between implantation (median: 2%, IQR:0-8) and 2-3 months post-transplant (median 8% IQR:4-15; p < 0.0001). Donation from younger or live donors was independently associated with smaller early post-transplant increases in ICD. There was no evidence for a difference in delta ICD between donation after cardiac death vs. donation after brain death, nor association with length of cold ischemia. After adjustment for GFR at the time of the second biopsy, delta ICD after three months did not predict allograft function at one yr. These findings suggest that graft damage develops shortly after transplantation and reflects donor factors, but does not predict future biochemical outcomes

Observation of optical torsional stiffness in a high optical power cavity

We have observed negative optical torsional rigidity in an 80 m suspended high optical power cavity that would induce the Sidles-Sigg instability as a result of sufficient circulating power. The magnitude of the negative optical spring constant per unit power is a few μN m/W as the result of the optical torsional stiffness in the yaw mode of a suspended mirror Fabry-Ṕrot cavity. It has been observed to depend on the g -factor of the cavity which is in agreement with the Sidles-Sigg theory. © 2009 American Institute of Physics.Yaohui Fan, Lucienne Merrill, Chunnong Zhao, Li Ju, David Blair, Bram Slagmolen, David Hosken, Aidan Brooks, Peter Veitch, Damien Mudge, and Jesper Munch