Annotated provisional agenda. Fifty-sixth meeting of the Presiding Officers of the Regional Conference on Women in Latin America and the Caribbean

<p>Data are individual scores. Left graph: dyskinesia score in MPTP-treated marmosets having received Radiprodil (2 mg/kg) and Tozadenant (150 mg/kg) treatment alone or in combination over the 10-hour of behavioural recording. Right graph: dyskinesia scores recorded over 5 hours after L-Dopa treatment (8 mg/kg; **, p<0.05, Mann-Withney test).</p

Comparison of the effects of the “Radiprodil and Tozadenant” combination with the effects of L-Dopa on the level of locomotor activity in MPTP-treated marmosets.

<p><i>Left graph</i>: Lomotor activity (mean value ± SEM) measured over 10 hours following Radiprodil (2 mg/kg) and Tozadenant (150 mg/kg) treatment given alone or in combination in MPTP-treated marmosets (n = 12). Five hours after the first drug administration, a second administration was given and, at the same time, novel objects were introduced in the testing cage. * <i>versus</i> Radiprodil group (one-way ANOVA, p<0.01, followed by planned contrasts). <i>Right graph</i>: Locomotor activity measured over 5 hours follwing L-Dopa (8 mg/kg). p<0.001 L-Dopa <i>v</i>s Vehicle (Student test on total score).</p

Statistical analysis of the “Radiprodil and Tozandenant” combination in MPTP-treated marmosets for the disability score.

<p>Sum of the number of observation sequences (means ± SEM) wherein the primates’ behaviour was assessed as ‘on-time’ activity (motor disability scoring<8). The behaviour was scored over 10 hours after Radiprodil (2 mg/kg) and Tozadenant (150 mg/kg) treatment given alone or in combination in MPTP-treated marmosets (n = 12/group). Period 1 corresponds to the effect observed when the animals are in the usual testing cage. Period 2 indicates the effect associated with the second drug administration and the introduction of a novel object in the testing environment (Two-way mixed ANOVA followed by planned contrasts with *, p<0.05 and **, p<0.01).</p