The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation

There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation

The relationship between ECE and CSE in the training field. The Italian case.

The paper aims to contribute to the debate on pre-school and primary education training through the analysis of a country case. The first part of the paper will explore how the relationships between these two parts of the education system has been constructed and evolved over time in the context of local socio-cultural conditions. The second part of the paper will investigate the impact that such developments had on the professional preparation of pre-school and primary school teachers and it will give a critical account of recent trends starting from a rigorous analysis of pathways of continuity and change. The assumption underlying this paper is that any reflection on the design of teacher\u2019s initial preparation shall not overlook the historical processes and the local socio-cultural conditions within which educational systems are embedded and constantly changing. The concluding part of the paper will outline conceptual categories for looking critically into the challenges and possibilities posed by recent reform trends concerning teachers\u2019 professional preparation across the early childhood and compulsory school education field