Creación de una agencia de viajes on-line receptiva especializada en la zona de la Safor (Valencia)

[ES] Actualmente el mundo de la intermediación turística está experimentado grandes cambios. Para poder competir las agencias de viajes se han visto obligadas a adaptar y asumir nuevas estrategias de comercialización de sus productos turísticos. Una de estas estrategias es la especialización que permite ofrecer producto propio diferenciado del resto de la oferta turística del mercado obteniendo un mayor conocimiento del nicho del mercado al que se dirigen. En este proyecto se describirán ordenadamente los pasos a seguir para la creación una agencia de viajes receptiva encargada de captar, recibir y dar información al visitante en el destino con el objetivo de facilitarle su experiencia turística. La idea fundamental de este trabajo es destacar la potencialidad de las agencias receptivas como elementos revitalizadores de la cultura y atractivos locales de la comarca de la Safor. Así, Se diseñarán productos turísticos en la forma de excursiones, visitas de un día, incluso paquetes turísticos. El ámbito de actuación de esta nueva empresa será la comarca de La Safor (Valencia). No obstante, al actuar como agencia receptiva y según la nueva Ley de Ocio y Hospitalidad de la Comunitat Valenciana , estas intermediarias podrán igualmente puedan ofrecer otros servicios o destinos de otros ámbitos geográficos.[EN] Currently the world of tourism brokerage is experiencing great changes. In order to compete, travel agencies have been forced to adapt and assume new marketing strategies for their tourism products. One of these strategies is the specialization that allows you to offer your own product differentiated from the rest of the market's tourism offer. One of these strategies is the specialization that allows you to offer your own product differentiated from the rest of the market's tourism offer. This allows obtaining a greater knowledge of the niche of the market to which they are directed. In this project the steps to be followed will be described in order to create a receptive travel agency in charge of capturing and receive and give information to the visitor at the destination in order to facilitate your tourist experience. The fundamental idea of this work is to highlight the potential of the receptive The company will focus the region of the Safor (Valencia) agencies as revitalizing elements of the culture and local attractions of the Safor region. In this way they are designed in tourist products in the form of excursions, day trips, even tour packages. However, by acting as a receptive agency and according to the new Law of Leisure and Hospitality of the Valencian Community, these intermediaries may also offer other services or destinations from other geographical areas.Pestrikova, K. (2019). Creación de una agencia de viajes on-line receptiva especializada en la zona de la Safor (Valencia). Universitat Politècnica de València. http://hdl.handle.net/10251/134516TFG

Gashydrate Decomposition and Methane Flux in the Okhotsk Sea Area as Result of Seismo-Tectonic Activization

Far Eastern Branch of the Russian Academy of SciencesPromoting Environmental Pesearch in Pan-Japan Sea Area : Young Researchers\u27 Network, Schedule: March 8-10,2006,Kanazawa Excel Hotel Tokyu, Japan, Organized by: Kanazawa University 21st-Century COE Program, Environmental Monitoring and Prediction of Long- & Short- Term Dynamics of Pan-Japan Sea Area ; IICRC(Ishikawa International Cooperation Research Centre), Sponsors : Japan Sea Research ; UNU-IAS(United Nations University Institute of Advanced Studies)+Ishikawa Prefecture Government ; City of Kanazaw

Исследование механизмов, обеспечивающих реализацию прав детей от 1,5 до 3 лет на получение дошкольного образования

The scientific report examines the history of the emergence and formation of the system of public education of young children in Russia and abroad. The analysis focuses on the education of children from 1.5 to 3 years old. The necessity of a much larger-scale approach to the issues of additional professional education of teachers (retraining, advanced training), taking into account the specifics of the education of young children, is substantiated

Effect of the Bone Marrow Mesenchymal Stromal Cells Cytokine-Producing Activity on the Hematopoietic Ste

Hematopoietic stem cell transplantation is used to treat hemoblastoses and some other diseases. Depending on the diagnosis, autologous cells of the patient or allogeneic cells obtained from a healthy related or unrelated donor are used. A sufficient count of harvested hematopoietic progenitor cells is necessary for successful transplantation. Currently, stimulation of their egress from the bone marrow into the peripheral blood by a granulocyte colony-stimulating factor, followed by collection by leukapheresis, is widely used for their preparation. Hematopoietic stem cells leave the bone marrow niche formed by the stromal microenvironment when their holding bonds are interrupted. Mesenchymal stromal cells regulate the release of hematopoietic precursors by producing various cytokines and other biologically active substances. Therefore, the study of the functional properties of bone marrow mesenchymal cells can help in solving the problem of “poor” mobilizations that occur in patients with multiple myeloma.The aim of the study was to estimate the effectiveness of mobilization of hematopoietic stem cells depending on the cytokine-producing ability of mesenchymal stromal cells in the bone marrow of donors and patients with multiple myeloma.The yields of hematopoietic progenitors were studied in 10 donors (median age 27 years) and 18 patients with multiple myeloma (median age 57 years). In donors, the release of hematopoietic stem cells into the peripheral blood was stimulated by subcutaneous administration of G-CSF at a dose of 10 μg/kg/day. Patients with multiple myeloma received vinorelbine at a dose of 35 mg/m2 of body surface, followed by administration of G-CSF (10 μg/kg/day subcutaneously). A culture of mesenchymal stromal cells was obtained from bone marrow taken prior to mobilization and the content of interleukins IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α and IFN-γ in supernatants was studied by enzyme-linked immunosorbent assay using kits of reagents produced by Vector-Best (Novosibirsk).Patients with multiple myeloma were characterized by high secretion of the pro-inflammatory cytokine IL-2 (4.70 pg/ml vs 3.55 pg/ml in healthy individuals, p=0.003) and low IFN-γ (0.41 pg/ml vs 2.14 pg/ml in healthy, p<0.001), but no relationship was found between these cytokines and the hematopoietic stem cells yield. The present study showed that in patients with ineffective harvesting of hematopoietic precursors, secretion of IL-8 by stromal cells was low (308.08 pg/ml vs 561.29 pg/ml in healthy individuals, p=0.04).The obtained results are consistent with the literature data on the important role of IL-8 in the mobilization of hematopoietic stem cells, which allows to consider IL-8 as an informative marker for predicting the insufficient yields of hematopoietic precursors

Research of Mechanisms Ensuring the Realization of the Rights of Children From 1.5 to 3 Years Old To Receive Preschool Education

The scientific report examines the history of the emergence and formation of the system of public education of young children in Russia and abroad. The analysis focuses on the education of children from 1.5 to 3 years old. The necessity of a much larger-scale approach to the issues of additional professional education of teachers (retraining, advanced training), taking into account the specifics of the education of young children, is substantiated