Gravity and Geometric Phases

The behavior of a quantum test particle satisfying the Klein-Gordon equation in a certain class of 4 dimensional stationary space-times is examined. In a space-time of a spinning cosmic string, the wave function of a particle in a box is shown to acquire a geometric phase when the box is transported around a closed path surrounding the string. When interpreted as an Aharonov-Anandan geometric phase, the effect is shown to be related to the Aharonov-Bohm effect.Comment: 11 pages, latex fil

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers

Multiple Fingers – One Gestalt

The Gestalt theory of perception offered principles by which distributed visual sensations are combined into a structured experience (“Gestalt”). We demonstrate conditions whereby haptic sensations at two fingertips are integrated in the perception of a single object. When virtual bumps were presented simultaneously to the right hand’s thumb and index finger during lateral arm movements, participants reported perceiving a single bump. A discrimination task measured the bump’s perceived location and perceptual reliability (assessed by differential thresholds) for four finger configurations, which varied in their adherence to the Gestalt principles of proximity (small vs. large finger separation) and synchrony (virtual spring to link movements of the two fingers vs. no spring). According to models of integration, reliability should increase with the degree to which multi-finger cues integrate into a unified percept. Differential thresholds were smaller in the virtual-spring condition (synchrony) than when fingers were unlinked. Additionally, in the condition with reduced synchrony, greater proximity led to lower differential thresholds. Thus, with greater adherence to Gestalt principles, thresholds approached values predicted for optimal integration. We conclude that the Gestalt principles of synchrony and proximity apply to haptic perception of surface properties and that these principles can interact to promote multi-finger integration. Lezkan, A. Manuel, S.G. Colgate, J.E., Klatzky, R.L,. Peshkin, M.A. & Drewing, K. (2016). Multiple Fingers – One Gestalt. IEEE Transactions on Haptics, 9(2), 255-266. The Zip file contains all data relative to the publication. A description of the variables is contained in the file VARIABLE_CODES.tx