HEPATOPROTECTIVE ACTIVITY OF ASPARAGUS RACEMOSUS ROOT EXTRACT ON LIPOPOLYSACCHARIDE INDUCED OXIDATIVE STRESS IN RATS

Objective: Lipopolysaccharide (endotoxin) produces an inflammatory condition leading to multiple organ failure. LPS most potent bacterial products are used for induction of host oxidative stress responses and liver injury. Methods: Present study was undertaken to investigate the effect of Asparagus racemosus Willd. root extract in lipopolysaccharide (LPS) induced oxidative stress in rats  by measuring oxidative stress markers, nitric oxide, liver function test and cytokines. Results: The obtained data showed that LPS administration significantly reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), total cholesterol (TC) and albumin (ALB).   There was significant increase in malondialdehyde (MDA), cytokines activity, serum aspartate transaminase(AST), alanine transaminase(ALT), alkaline phosphate (ALP), total bilirubin (TB) and nitric oxide(NO).   Conclusion: The methanolic extract of Asparagus   racemosus (MEAR) administration significantly (P<0.05) reduced LPS-induced oxidative stress by  normalizing liver GSH, SOD, CAT, MDA,  NO, cytokines and liver function markers. MEAR significantly increased ALB and TC level. Results suggest that MEAR protects the liver against liver toxicity induced by LPS.                                   Peer Review History: Received 13 February 2019;   Revised 15 February; Accepted 5 March, Available online 15 March 2019 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 8/10 Reviewer(s) detail: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected] Dr. Nuray Arı, Ankara University, Turkiye, [email protected] Similar Articles: STUDY ON FRESH LEAF AQUEOUS EXTRACT OF FLACOURTIA INDICA FOR HEPATOPROTECTIVE, ANTI-ANEMIC AND HYPOGLYCEMIC ABILITIES IN CCL4 INDUCED HEPATOTOXICITY IN ALBINO WISTAR RATS HEPATOPROTECTIVE ACTIVITY OF ASPARAGUS RACEMOSUS ROOT EXTRACT ON LIPOPOLYSACCHARIDE INDUCED OXIDATIVE STRESS IN RAT

Traditional uses, Pharmacology and Phytochemistry of National flower of Nepal Rhododendron arboreum: A Review

Methods: This review provides scientific grounds in the literature for the phytochemical and pharmacological activities of Rhododendron arboreum, from 2010- 2021. Chiefly three bibliographic databases were used as the main sources of information (Google scholar, PubMed, and Science Direct). The keywords used in this research are as follows: “Phytochemical”, “National flower”, “Bioactive compounds”, “Pharmacology” and “Rhododendron arboreum”. Results: Various studies were included in this review according to the required criteria, including phytochemical and traditional uses. Rhododendron arboreum contains flavonoids alkaloids, terpenoids, glycosides, steroids, anthraquinones, saponins and tannins. Pharmacological and traditional uses of this plant on the basis of presence of above active ingredients. Keywords: Bioactive compounds, National flower, Rhododendron arboreu