Methods for the analysis of Sunset Yellow FCF (E110) in food and beverage products-a review

Food colorants are categorized into natural and synthetic dyes. One of the famous synthetic food dyes is Sunset Yellow FCF (E110) which belongs to the family of azo dyes and widely used in food industry. However, Sunset Yellow has positive and negative effects as well, by giving attractive physical appearance and consumer acceptance. At the same time, it can cause as attention deficit hyperactivity disorder (ADHD), is a group of behavioural symptoms that include inattentiveness, hyperactivity and impulsiveness, cancer and some other health effects with an excess consumption. Due to the arising of the health issues for mankind, researchers should give more priority to develop advance techniques for determination of Sunset Yellow in food and beverage products. The main aim of this review paper is critically discussed on the acceptable daily intake (ADI), toxicology, extraction methods, and analytical and electrochemical sensor methods for determination of Sunset Yellow

A Chemist with a Strange Etiology of Rhabdomyolysis: A Case Report of a Rare Toxicological Emergency

Introduction: Chloroform, a halogenated hydrocarbon, causes central nervous depression, hepatotoxicity, nephrotoxicity, and rhabdomyolysis. Historically, chloroform had been used as a general anaesthetic and today is still used in chemical industries. Lack of proper personal protective equipment and adequate knowledge about its toxic effects can lead to serious harm.Case report: A 33-year-old gentleman presented to the emergency department (ED) with altered mental status. Given his depressed mental status, the decision was made to intubate shortly after arrival for airway protection. Further history raised suspicion of occupational chloroform exposure. Brown-colored urine further strengthened suspicion of chloroform poisoning with resultant rhabdomyolysis. Forced alkaline diuresis and N-acetylcysteine were started in the ED. His mental status and respiratory efforts improved on hospital day two, and he was ultimately extubated. Creatine phosphokinase and myoglobin levels were initially high but gradually came down by hospital day six. On hospital day 10, the patient was deemed stable and safely discharged.Conclusion: A patient with chloroform inhalation who suffered resultant rhabdomyolysis and hepatotoxicity was successfully treated with early initiation of forced alkaline diuresis, N-acetylysteine, and hemodialysis