Crude and adjusted odds ratios for breast cancer clinicopathological subtypes of women with diabetes compared to women without diabetes in subgroups of menopausal status using (multinomial) logistic regression.

<p>Crude and adjusted odds ratios for breast cancer clinicopathological subtypes of women with diabetes compared to women without diabetes in subgroups of menopausal status using (multinomial) logistic regression.</p

Crude and adjusted odds ratios for breast cancer clinicopathological subtypes of women with diabetes treated with or without insulin compared to women without diabetes in subgroups of menopausal status using (multinomial) logistic regression.

<p>Crude and adjusted odds ratios for breast cancer clinicopathological subtypes of women with diabetes treated with or without insulin compared to women without diabetes in subgroups of menopausal status using (multinomial) logistic regression.</p

Flow chart of patient identification and selection.

<p>Stratified by age at breast cancer diagnosis (≤50 and >50 years), women with diabetes were 2:1 frequency-matched on year of birth and age at breast cancer diagnosis (both in 10-year categories) to women without diabetes, to select ~300 patients with tumor tissue available. ^ǂ Exact numbers <5 cannot be shown according to regulations of Statistics Denmark.</p

Additional file 1 of Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Additional file 1. Supplementary tables and figures. Table S1 summarizes the clinical and pathological patient characteristics. Table S2 and S3 provide sequence information for primers and probes used for quantitative RT-PCR analyses. Table S4 and S5 give detailed information on the statistics analyses in Figs. 1 and 9. Figure S1 shows patterns of gene expression for carbonic anhydrases across breast cancer molecular subtypes. Figure S2 and S3 provide survival curves for Luminal A (Fig. S2) and Luminal B (Fig. S3) breast cancer patients stratified for carbonic anhydrase expression