Propionibacterium acnes infections in patients with idiopathic scoliosis: a case-control study and review of the literature.

Purpose:Surgical site infection (SSI) caused by Propionibacterium acnes is an infrequent but devastating complication after spinal fusion. The purpose of this study was to identify risk factors for SSI with Propionibacterium acnes after spinal fusion for juvenile and adolescent idiopathic scoliosis (JIS and AIS). Methods:A case-control study was performed. Each case was matched 2:1 for age, gender and diagnosis. Retrospective chart review was performed to obtain relevant demographic, surgical and clinical data for all cases and controls. Statistical analysis included paired t-test and McNemar test, as well as exact logistic regression and robust regression models. Results:This study included ten infection cases (eight AIS, two JIS) and 20 controls (16 AIS, four JIS). In total, six infected cases presented within two weeks of the index procedure (acute infection) and four infected cases presented more than one year from the index procedure (delayed infection). The most common presentation for acute infections was wound drainage, while back pain was more common in delayed infections. All infections were successfully treated with surgical irrigation and debridement and postoperative antibiotics. Hardware was removed for patients with delayed infections. The strongest risk factor for infection was increased requirement for blood transfusion, but it did not reach statistical significance. Conclusion:SSI with Propionibacterium acnes is an important complication after spinal fusion for idiopathic scoliosis. These infections can be successfully treated, but larger studies are needed to further identify risk factors and establish standardized guidelines for the treatment and prevention of this complication. Level of Evidence Level III

Discovery of a very X-ray luminous galaxy cluster at z=0.89 in the WARPS survey

We report the discovery of the galaxy cluster ClJ1226.9+3332 in the Wide Angle ROSAT Pointed Survey (WARPS). At z=0.888 and L_X=1.1e45 erg/s (0.5-2.0 keV, h_0=0.5) ClJ1226.9+3332 is the most distant X-ray luminous cluster currently known. The mere existence of this system represents a huge problem for Omega_0=1 world models. At the modest (off-axis) resolution of the ROSAT PSPC observation in which the system was detected, ClJ1226.9+3332 appears relaxed; an off-axis HRI observation confirms this impression and rules out significant contamination from point sources. However, in moderately deep optical images (R and I band) the cluster exhibits signs of substructure in its apparent galaxy distribution. A first crude estimate of the velocity dispersion of the cluster galaxies based on six redshifts yields a high value of 1650 km/s, indicative of a very massive cluster and/or the presence of substructure along the line of sight. While a more accurate assessment of the dynamical state of this system requires much better data at both optical and X-ray wavelengths, the high mass of the cluster has already been unambiguously confirmed by a very strong detection of the Sunyaev-Zel'dovich effect in its direction (Joy et al. 2001). Using ClJ1226.9+3332 and ClJ0152.7-1357 (z=0.835), the second-most distant X-ray luminous cluster currently known and also a WARPS discovery, we obtain a first estimate of the cluster X-ray luminosity function at 0.8<z<1.4 and L_X>5e44 erg/s. Using the best currently available data, we find the comoving space density of very distant, massive clusters to be in excellent agreement with the value measured locally (z<0.3), and conclude that negative evolution is not required at these luminosities out to z~1. (truncated)Comment: accepted for publication in ApJ Letters, 6 pages, 2 figures, uses emulateapj.st

Large-Scale Regular Morphological Patterns in the Radio Jet of NGC 6251

We report on large-scale, regular morphological patterns found in the radio jet of the nearby radio galaxy NGC 6251. Investigating morphological properties of this radio jet from the nucleus to a radial distance of $\sim$ 300 arcsec ($\approx$ 140 kpc) mapped at 1662 MHz and 4885 MHz by Perley, Bridle, & Willis, we find three chains, each of which consists of five radio knots. We also find that eight radio knots in the first two chains consist of three small sub-knots (the triple-knotty substructures). We discuss the observational properties of these regular morphological patterns.Comment: 8 figures, 15 pages, accepted for publication in A

Critical view of WKB decay widths

A detailed comparison of the expressions for the decay widths obtained within the semiclassical WKB approximation using different approaches to the tunneling problem is performed. The differences between the available improved formulae for tunneling near the top and the bottom of the barrier are investigated. Though the simple WKB method gives the right order of magnitude of the decay widths, a small number of parameters are often fitted. The need to perform the fitting procedure remaining consistently within the WKB framework is emphasized in the context of the fission model based calculations. Calculations for the decay widths of some recently found super heavy nuclei using microscopic alpha-nucleus potentials are presented to demonstrate the importance of a consistent WKB calculation. The half-lives are found to be sensitive to the density dependence of the nucleon-nucleon interaction and the implementation of the Bohr-Sommerfeld quantization condition inherent in the WKB approach.Comment: 18 pages, Late

Frequentist and Bayesian measures of confidence via multiscale bootstrap for testing three regions

A new computation method of frequentist $p$-values and Bayesian posterior probabilities based on the bootstrap probability is discussed for the multivariate normal model with unknown expectation parameter vector. The null hypothesis is represented as an arbitrary-shaped region. We introduce new parametric models for the scaling-law of bootstrap probability so that the multiscale bootstrap method, which was designed for one-sided test, can also computes confidence measures of two-sided test, extending applicability to a wider class of hypotheses. Parameter estimation is improved by the two-step multiscale bootstrap and also by including higher-order terms. Model selection is important not only as a motivating application of our method, but also as an essential ingredient in the method. A compromise between frequentist and Bayesian is attempted by showing that the Bayesian posterior probability with an noninformative prior is interpreted as a frequentist $p$-value of ``zero-sided'' test