How Teaching About Therapeutic Jurisprudence Can Be a Tool of Social Justice, and Lead Law Students to Personally and Socially Rewarding Careers: Sexuality and Disability as a Case Example

Therapeutic jurisprudence (TJ) asks us to look at law as it actually impacts people’s lives and focuses on the law’s influence on emotional life and psychological well-being. It suggests that law should value psychological health, should strive to avoid imposing anti-therapeutic consequences whenever possible, and — when consistent with other values served by law — should attempt to bring about healing and wellness. The ultimate aim of TJ is to determine whether legal rules and procedures or lawyer roles can or should be reshaped to enhance their therapeutic potential while not subordinating due process principles. An inquiry into therapeutic outcomes does not mean that therapeutic concerns ‘trump’ civil rights and civil liberties. TJ’s aim is to use the law to empower individuals, enhance rights, and promote well-being, And one of TJ’s central principles is a commitment to dignity. We know that, in many cases, law students’ desire to engage in pressing social issues fades as they become both disillusioned and passive over the course of their law school experience, and this disillusionment is often abetted by the attitudes of their professors and the way that law school is traditionally taught. We believe that the adoption of TJ principles is a way to end this disillusionment and help return students to a focus on social justice, as a way of better insuring more personally enriching and rewarding careers. In this paper, we consider this issue through the prism of teaching (and learning about) the intersection between sexuality and disability. In other articles, the authors have argued that the way society both (often simultaneously) demonizes and infantilizes persons with disability when questions of sexuality are raised reflects the level of sanism and pretextuality that permeates all of mental disability law. In these articles, we have argued further that a therapeutic jurisprudence perspective can best insure that the persons in question have voice, and are treated with dignity. In this paper, we discuss these issues, as well as examine the ways in which intersectionality — expanding our view to include factors such as race, sex, gender and sexual orientation — can compound the difficulty of discussing this topic. We seek to lay out a blueprint for other faculty members — senior, junior and future — to employ in teaching about marginalized populations, especially in substantive areas (such as this) that often evoke wildly negative reactions, even among classically “left/progressive” faculty and students

Two Phosphodiesterases from Ustilago Maydis Share Structural and Biochemical Properties with Non-Fungal Phosphodiesterases

The dependence of Protein Kinase A (PKA) activity on cAMP levels is an important facet of the dimorphic switch between budding and filamentous growth as well as for pathogenicity in some fungi. To better understand these processes in the pathogenic fungus Ustilago maydis, we characterized the structure and biochemical functions of two phosphodiesterase (PDE) genes. Phosphodiesterases are enzymes involved in cAMP turnover and thus, contribute to the regulation of the cAMP-PKA signaling pathway. Two predicted homologs of PDEs were identified in the genome of U. maydis and hypothesized to be involved in cAMP turnover, thus regulating activity of the PKA catalytic subunit. Both umpde1 and umpde2 genes contain domains associated with phosphodiesterase activity predicted by InterPro analysis. Biochemical characterization of recombinantly produced UmPde1 (U. maydis Phosphodiesterase I) and UmPde2 demonstrated that both enzymes have phosphodiesterase activity in vitro, yet neither was inhibited by the phosphodiesterase inhibitor IBMX. Moreover, UmPde1 is specific for cAMP, while UmPde2 has broader substrate specificity, utilizing cAMP and cGMP as substrates. In addition, UmPde2 was also found to have nucleotide phosphatase activity that was higher with GMP compared to AMP. These results demonstrate that UmPde1 is a bona fide phosphodiesterase, while UmPde2 has more general activity as a cyclic nucleotide phosphodiesterase and/or GMP/AMP phosphatase. Thus, UmPde1 and UmPde2 likely have important roles in cell morphology and development and share some characteristics with a variety of non-fungal phosphodiesterases

Engineering spin squeezing in a 3D optical lattice with interacting spin-orbit-coupled fermions

One of the most important tasks in modern quantum science is to coherently control and entangle many-body systems, and to subsequently use these systems to realize powerful quantum technologies such as quantum-enhanced sensors. However, many-body entangled states are difficult to prepare and preserve since internal dynamics and external noise rapidly degrade any useful entanglement. Here, we introduce a protocol that counterintuitively exploits inhomogeneities, a typical source of dephasing in a many-body system, in combination with interactions to generate metrologically useful and robust many-body entangled states. Motivated by current limitations in state-of-the-art three-dimensional (3D) optical lattice clocks (OLCs) operating at quantum degeneracy, we use local interactions in a Hubbard model with spin-orbit coupling to achieve a spin-locking effect. In addition to prolonging inter-particle spin coherence, spin-locking transforms the dephasing effect of spin-orbit coupling into a collective spin-squeezing process that can be further enhanced by applying a modulated drive. Our protocol is fully compatible with state-of-the-art 3D OLC interrogation schemes and may be used to improve their sensitivity, which is currently limited by the intrinsic quantum noise of independent atoms. We demonstrate that even with realistic experimental imperfections, our protocol may generate $\sim10$--$14$ dB of spin squeezing in $\sim1$ second with $\sim10^2$--$10^4$ atoms. This capability allows OLCs to enter a new era of quantum enhanced sensing using correlated quantum states of driven non-equilibrium systems.Comment: 20 pages, 12 figure

Cross-Cultural Perspectives on the Classification of Children With Disabilities: Part II. Implementing Classification Systems in Schools

This article is the second in a 2-part synthesis of an international comparative seminar on the classification of children with disabilities. In this article, the authors discuss classification frameworks used in identifying children for the purpose of providing special education and related services. The authors summarize 7 papers that addressed aspects of disability classification in educational systems in the United States and the United Kingdom. They discuss current policies for determining which children receive special education services, the origins and evolution of these policies, and current dilemmas and challenges associated with classification schemes and the provision of special education. The authors also describe emerging data and possible models and practices that might be used in educational systems. They conclude with the recognition that both formal and informal educational classification systems will continue to be required within a system that must address the competing priorities of individual needs and the broader social and community goals of education. However, as was argued in the previous article, by understanding the mix of intentions that underpin these policies, as well as periodically reviewing the norms that underlie them, it may be possible to move classification to descriptors that can be used to efficiently and effectively define educational needs and distribute resources

High Reynolds number experimentation in the US Navy's William B Morgan Large Cavitation Channel

The William B Morgan Large Cavitation Channel (LCC) is a large variable-pressure closed-loop water tunnel that has been operated by the US Navy in Memphis, TN, USA, since 1991. This facility is well designed for a wide variety of hydrodynamic and hydroacoustic tests. Its overall size and capabilities allow test-model Reynolds numbers to approach, or even achieve, those of full-scale air- or water-borne transportation systems. This paper describes the facility along with some novel implementations of measurement techniques that have been successfully utilized there. In addition, highlights are presented from past test programmes involving (i) cavitation, (ii) near-zero pressure-gradient turbulent boundary layers, (iii) the near-wake flow characteristics of a two-dimensional hydrofoil and (iv) a full-scale research torpedo.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/49060/2/mst5_9_001.pd

Seasonal sea surface cooling in the equatorial Pacific cold tongue controlled by ocean mixing

Sea surface temperature (SST) is a critical control on the atmosphere(1), and numerical models of atmosphere-ocean circulation emphasize its accurate prediction. Yet many models demonstrate large, systematic biases in simulated SST in the equatorial 'cold tongues' (expansive regions of net heat uptake from the atmosphere) of the Atlantic(2) and Pacific(3) oceans, particularly with regard to a central but little-understood feature of tropical oceans: a strong seasonal cycle. The biases may be related to the inability of models to constrain turbulent mixing realistically(4), given that turbulent mixing, combined with seasonal variations in atmospheric heating, determines SST. In temperate oceans, the seasonal SST cycle is clearly related to varying solar heating(5); in the tropics, however, SSTs vary seasonally in the absence of similar variations in solar inputs(6). Turbulent mixing has long been a likely explanation, but firm, long-term observational evidence has been absent. Here we show the existence of a distinctive seasonal cycle of subsurface cooling via mixing in the equatorial Pacific cold tongue, using multi-year measurements of turbulence in the ocean. In boreal spring, SST rises by 2 kelvin when heating of the upper ocean by the atmosphere exceeds cooling by mixing from below. In boreal summer, SST decreases because cooling from below exceeds heating from above. When the effects of lateral advection are considered, the magnitude of summer cooling via mixing (4 kelvin per month) is equivalent to that required to counter the heating terms. These results provide quantitative assessment of how mixing varies on timescales longer than a few weeks, clearly showing its controlling influence on seasonal cooling of SST in a critical oceanic regime.Keywords: Balance, Instability, Turbulence, Tropical Pacific, Annual cycle, temperature, Budget, Models, Shear flo

A modified law-of-the-wall applied to oceanic bottom boundary layers

Near the bottom, the velocity profile in the bottom boundary layer over the continental shelf exhibits a characteristic law-of-the-wall that is consistent with local estimates of friction velocity from near-bottom turbulence measurements. Farther from the bottom, the velocity profile exhibits a deviation from the law-of-the-wall. Here the velocity gradient continues to decrease with height but at a rate greater than that predicted by the law-of-the-wall with the local friction velocity. We argue that the shape of the velocity profile is made consistent with the local friction velocity by the introduction of a new length scale that, near the boundary, asymptotes to a value that varies linearly from the bottom. Farther from the boundary, this length scale is consistent with the suppression of velocity fluctuations either by stratification in the upper part of the boundary layer or by proximity to the free surface. The resultant modified law-of-the-wall provides a good representation of velocity profiles observed over the continental shelf when a local estimate of the friction velocity from coincident turbulence observations is used. The modified law-of-the- wall is then tested on two very different sets of observations, from a shallow tidal channel and from the bottom of the Mediterranean outflow plume. In both cases it is argued that the observed velocity profile is consistent with the modified law-of-the-wall. Implicit in the modified law-of-the-wall is a new scaling for turbulent kinetic energy dissipation rate. This new scaling diverges from the law-of-the-wall prediction above 0.2D (where D is the thickness of the bottom boundary layer) and agrees with observed profiles to 0.6D

Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure1

An increase in the frequency of azole-resistant Aspergillus fumigatus has emerged