8 research outputs found
Reaction of isatin with alkylating agents with acidic methylenes
The reaction of isatin (1) with different alkyl halides 2 and alkaline carbonates in aprotic polar solventsleads mainly to N-alkyl derivatives 3. The use of alkylating agents that have acidic methylenes leads tocompetitive formation of the corresponding epoxide 5. The formation of 5 is favored by low-polarity solvents at low temperatures and strong bases. Epoxides 5c, d obtained using NaEtOH/EtOH at 0?5 C are transformed into the corresponding 4-quinolinones 6 at higher temperatures. The use of Ag2CO3 allows obtaining compounds 3 as major products, along with varying amounts of labile O-alkyl derivatives 4 and dimerization products.Fil: Shmidt, MarĂa Sol. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Perillo, Isabel Amalia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: González, Mercedes. Universidad de la RepĂşblica. Facultad de Ciencias; UruguayFil: Blanco, MarĂa de Las Mercedes. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentin
New Green Synthesis and Antineoplastic Activity of bis (3-arylimidazolidinyl-1)methanes
A new green synthesis and anti-tumor activity of the series of bis (3-arylimidazolidinyl-1) methanes 1 - 6 are described. The compounds were synthesized from the corresponding N-arylethylenediamine and trioxane as source of formaldehyde and the reactions were performed in heterogeneous phase catalyzed by an acidic ion-exchange resin (Amberlyst 15). The compounds were tested with the Sulforhodamine B assay according to the protocol of the National Cancer Institute for several cell lines. The results were expressed as percentage inhibition of growth cell in comparison with the full growth of the cells without treatment. Cytotoxicity on normal cells using the Annexing-PI staining and flow cytometry has been evaluated. The parent compound, bis(3-phenylimidazolidinyl-1)methane 1 and the monohalogenated derivatives 4-chlorophenyl 3 and 3-bromophenyl 5 showed antineoplastic activity, 60%, 82% and 89% inhibition growth cell respectively on the human colon cell line (HCT116). The 4-tolyl derivative 6 presented inhibitory activity (73% inhibition of growth cell) on human lung adenocarcinoma cell line (A549) and 62% on human mammary cell line MCF-7.Fil: Caterina, Maria Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Quimica Orgánica; Argentina;Fil: Perillo, Isabel Amalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Quimica Orgánica; Argentina;Fil: Villalonga, Ximena Soledad. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Estudios Farmacologicos y Botánicos; Argentina;Fil: Amiano, Nicolás Oscar. Universidad de Buenos Aires. Facultad de Medicina. Cat.de FarmacologĂa; Argentina;Fil: PayĂ©s, Cristian. Universidad de Buenos Aires. Facultad de Medicina. Cat.de FarmacologĂa; Argentina;Fil: Sanchez, Mercedes Leonor. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Estudios Farmacologicos y Botánicos; Argentina;Fil: Salerno, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de QuĂmica Orgánica;Argentina
1,6- and 1,7-Naphthyridines IV. Synthesis of hydroxycarboxamide derivatives
A series of 8-hydroxy-1,6-naphthyridin-5(6H)-one-7-carboxamides 1 and the isomeric 5-hydroxy-1,7-naphthyridin-8(7H)-one-6-carboxamides 2 were synthesized. N-Lactam unsubstituted compounds 1a-c and 2a,b were obtained by alkoxide-induced rearrangement of the corresponding quinolinimidoacetamides 3. Compounds 1e,f and 2e,f were synthesized by heterocyclization of the corresponding quinolinamic esters 6 and 7. Spectroscopic properties (uv, ir, 1H and 13C nmr and ms) were analyzed and confirmed the proposed structures.Fil: Blanco, MarĂa de Las Mercedes. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Schapira, Celia B.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Levin, Gustavo Javier. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro de Investigaciones y Transferencia de Entre RĂos. Universidad Nacional de Entre RĂos. Centro de Investigaciones y Transferencia de Entre RĂos; ArgentinaFil: Perillo, Isabel Amalia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; Argentin
www.mdpi.org/molecules Simple and Efficient Microwave Assisted N-Alkylation of Isatin
Abstract: We present herein the results of microwave promoted N-alkylations of isatin (1) with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried out under different conditions, always employing methodologies compatible with MW assisted chemistry. Generation of isatin anion employing diverse bases and solvents or using the preformed isatin sodium salt was tested. The best results were achieved using K2CO3 or Cs2CO3 and a few drops of N,N-dimethylformamide or N-methyl-2-pyrrolidinone. These reactions present noteworthy advantages over those carried out employing conventional heating
A novel alkylation procedure using MW irradiation for the synthesis of 1,2,3-trisubstituted 1,4,5,6,7,8-hexahydro-1,3-diazocinium salts from their corresponding 1,2-diaryldiazocines
In this work, we describe the synthesis of a series of 1,2,3-trisubstituted-1,4,5,6,7,8-hexahydro-1,3-diazocinium salts (1) by alkylation of the corresponding 1,2-diaryl-1,4,5,6,7,8-hexahydro-1,3-diazocines (2). Compounds 2 were obtained by ethyl polyphosphate-promoted cyclocondensation of N-aroyl-N0-arylpentamethylenediamines (3). Reaction of compounds 2 with alkyl iodides led to 1,2,3-trisubstituted 1,4,5,6,7,8-hexahydro-1,3-diazocinium iodides (1), a new family of cyclic amidinium salts. The best yields for the alkylation were achieved using a mixture of DCM–DMSO (10:1) as solvent. The reaction times of both, the cyclocondensation of compounds 3 and the reaction of 2 with alkyl halides, are dramatically decreased when using microwave irradiation.Fil: Ramirez, Maria de Los Angeles. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Ortiz, Mariela Gisela. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Salerno, Alejandra. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Perillo, Isabel Amalia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Blanco, MarĂa de Las Mercedes. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentin
Rapid and efficient synthesis of five- to eight-membered cyclic aminals under ultrasound irradiation
A simple, efficient, and green procedure has been developed for the synthesis of cyclic aminals from alkylenediamines and aqueous formaldehyde under ultrasound irradiation. Applying this methodology a series of five-to eight-membered 1,3-dibenzyl substituted aminals were synthesized in excellent yields after short reaction times. Results were compared to thermal conventional method. All novel compounds were identified and characterized by 1H and 13C NMR spectra.Fil: RamĂrez, MarĂa Amelia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Ortiz, Gisela. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Levin, Gustavo Javier. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de NanobiotecnologĂa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de NanobiotecnologĂa; ArgentinaFil: Mac Cormack, Walter Patricio. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de NanobiotecnologĂa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de NanobiotecnologĂa; ArgentinaFil: Blanco, MarĂa de Las Mercedes. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de NanobiotecnologĂa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de NanobiotecnologĂa; ArgentinaFil: Perillo, Isabel Amalia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Salerno, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentin
Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-Membered 1,3-Disubstituted Cyclic Amidinium Salts
Series of 1,3-dibenzyl-1H-4,5,6,7-tetrahydro-1,3-diazepinium and 1,4,5,6,7,8-hexahydro-1,3-diazocinium salts derivatives were efficiently synthesized in excellent yields by dehydrogenation of the corresponding N,N´-dibenzyl aminals employing N-bromosuccinimide (NBS) as dehydrogenating agent under ultrasound irradiation. The present methodology has proven to be simple, efficient and environmentally benign. All novel compounds were identified and characterized by 1H and 13C NMR spectra. The synthesized compounds were screened for their antimicrobial activities.Fil: Blanco, MarĂa M.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: ReamĂrez, MarĂa A.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Caterina, MarĂa C.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Perillo, Isabel Amalia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Oppezzo, Guido Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Shmidt, MarĂa Sol. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de MicrobiologĂa, InmunologĂa y BiotecnologĂa. Cátedra de MicrobiologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Di Conza, JosĂ© Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de MicrobiologĂa, InmunologĂa y BiotecnologĂa. Cátedra de MicrobiologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Salerno, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; Argentin