The retention behavior of antihypertensive drugs of the type angiotensin-converting enzyme inhibitors on thin layers of aminoplast

A rapid and simple method has been developed for chromatographic separation of the pharmacologically active components of some antibypertensive drugs. The active compounds - lisinopril, cilazapril, captopril, quinapril, and ramipril - were successfully separated on aminoplast layers with benzene-cyclohexane-methyl ethyl ketone, 15 + 10 + 15 (v/v), as mobile phase. The mechanism of retention and the correlation between lipophilicity and log P were both investigated

Study of the lipophilicity and retention behavior of some beta-adrenoceptor antagonists

The chromatographic behavior of some beta-adrenoceptor antagonists has been studied by RP HPTLC on C-18 with water-acetonitrile (phi = 0.2-0.7) and water-dioxane (phi = 0.1-0.5) mobile phases. The retention mechanism was investigated and retention constants, R-M(0) were determined by extrapolation. Good correlation was obtained between R-M(0) and the slope, m, of chromatographic equations. These retention constants correlated well with log P of beta-adrenoceptor antagonists and can be used as a measure of the lipophilicity of the compounds investigated