E-BOSS: An Extensive stellar BOw Shock Survey. II. Catalogue second release

Context. Stellar bow shocks have been studied not only observationally, but also theoretically since the late 1980s. Only a few catalogues of them exist. The bow shocks show emission along all the electromagnetic spectrum, but they are detected more easily in infrared wavelengths. The release of new and high-quality infrared data eases the discovery and subsequent study of new objects. Aims. We search stellar bow-shock candidates associated with nearby runaway stars, and gather them together with those found elsewhere, to enlarge the list of the E-BOSS first release. We aim to characterize the bow-shock candidates and provide a database suitable for statistical studies. We investigate the low-frequency radio emission at the position of the bow-shock features, that can contribute to further studies of high-energy emission from these objects. Methods. We considered samples from different literature sources and searched for bow-shaped structures associated with stars in the Wide-field Infrared Survey Explorer (WISE) images. We looked for each bow-shock candidate on centimeter radio surveys. Results. We reunited 45 bow-shock candidates and generated composed WISE images to show the emission in different infrared bands. Among them there are new sources, previously studied objects, and bow shocks found serendipitously. Five bow shocks show evidence of radio emission. Conclusions. Stellar bow shocks constitute an active field with open questions and enormous amounts of data to be analyzed. Future research at all wavelengths databases, and use of instruments like Gaia, will provide a more complete picture of these objects. For instance, infrared spectral energy distributions can give information about physical parameters of the bow shock matter. In addition, dedicated high-sensitivity radio observations can help to understand the radio-$\gamma$ connection.Comment: 20 pages, 11 figures, and 8 tables. Accepted for publication in A&

Evidence of non-thermal X-ray emission from HH 80

Protostellar jets appear at all stages of star formation when the accretion process is still at work. Jets travel at velocities of hundreds of km/s, creating strong shocks when interacting with interstellar medium. Several cases of jets have been detected in X-rays, typically showing soft emission. For the first time, we report evidence of hard X-ray emission possibly related to non-thermal processes not explained by previous models of the post-shock emission predicted in the jet/ambient interaction scenario. HH 80 is located at the south head of the jet associated to the massive protostar IRAS 18162-2048. It shows soft and hard X-ray emission in regions that are spatially separated, with the soft X-ray emission region situated behind the region of hard X-ray emission. We propose a scenario for HH 80 where soft X-ray emission is associated to thermal processes from the interaction of the jet with denser ambient matter and the hard X-ray emission is produced by synchrotron radiation at the front shock.Comment: Accepted for publication in ApJ

Pheromone-mediated mating disruption of the European grain moth Nemapogon granellus in ham factories

Nemapogon granellus is a lepidopteran species that can cause significant damage to stored animal products such as meats, sausages and cheeses. In the warehouses where such products are stored, pheromone-based control ap-proaches can avoid or reduce insecticide chemical treatments and be more effective than traditional control methods. This study aimed to evaluate the effectiveness of mating disruption (MD) techniques to control N. granellus populations in ham factories. Trials were conducted in two factories located in Northern Italy. In both locations two warehouses were selected: a warehouse test where dispensers, loaded with 10 mg of N. granellus pheromone, were deployed at a density ranging from 1 unit/22.5 m3 (factory A) to 1 unit/25 m3 (factory B), and a control warehouse left untreated. To assess the mating disruption efficacy, the reduction of the number of mated females in water traps, placed in control and treated warehouses, was used as main parameter. The results indicated a substantial reduction in mated females in the treated warehouses in comparison with control warehouses in both the sites of experiments. In detail, the total number of mated females sampled in water traps was above 90% in control warehouses, in warehouses treated with MD technique this percentage was below 50%. In addition, a "trap shutdown" effect was recorded in MD treated warehouses of both factories. These findings suggest that mating disruption is a promising technique that can be positively applied in the integrated pest management of N. granellus in ham factories

Detection of nonthermal emission from the bow shock of a massive runaway star

The environs of massive, early-type stars have been inspected in recent years in the search for sites where particles can be accelerated up to relativistic energies. Wind regions of massive binaries that collide have already been established as sources of high-energy emission; however, there is a different scenario for massive stars where strong shocks can also be produced: the bow-shaped region of matter piled up by the action of the stellar strong wind of a runaway star interacting with the interstellar medium. We study the bow-shock region produced by a very massive runaway star, BD+43 3654, to look for nonthermal radio emission as evidence of a relativistic particle population. We observed the field of BD+43 3654 at two frequencies, 1.42 and 4.86 GHz, with the Very Large Array (VLA), and obtained a spectral index map of the radio emission. We have detected, for the first time, nonthermal radio emission from the bow shock of a massive runaway star. After analyzing the radiative mechanisms that can be at work, we conclude that the region under study could produce enough relativistic particles whose radiation might be detectable by forthcoming gamma-ray instruments, like CTA North.Comment: Accepted in Astronomy and Astrophysics Letter

In silico identification of small molecules as new cdc25 inhibitors through the correlation between chemosensitivity and protein expression pattern

The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. In this work, a set of small molecules were identified as Cdc25 modulators by applying a mixed ligand-structure-based approach and taking advantage of the correlation between the chemosensitivity of selected structures and the protein expression pattern of the proposed target. In the first step of the in silico protocol, a set of molecules acting as Cdc25 inhibitors were identified through a new ligand-based protocol and the evaluation of a large database of molecular structures. Subsequently, induced-fit docking (IFD) studies allowed us to further reduce the number of compounds biologically screened. In vitro antiproliferative and enzymatic inhibition assays on the selected compounds led to the identification of new structurally heterogeneous inhibitors of Cdc25 proteins. Among them, J3955, the most active inhibitor, showed concentration-dependent antiproliferative activity against HepG2 cells, with GI50 in the low micromolar range. When J3955 was tested in cell-cycle perturbation experiments, it caused mitotic failure by G2/M-phase cell-cycle arrest. Finally, Western blotting analysis showed an increment of phosphorylated Cdk1 levels in cells exposed to J3955, indicating its specific influence in cellular pathways involving Cdc25 proteins

Antiproliferative Activity Predictor: A New Reliable In Silico Tool for Drug Response Prediction against NCI60 Panel

In vitro antiproliferative assays still represent one of the most important tools in the anticancer drug discovery field, especially to gain insights into the mechanisms of action of anticancer small molecules. The NCI-DTP (National Cancer Institute Developmental Therapeutics Program) undoubtedly represents the most famous project aimed at rapidly testing thousands of compounds against multiple tumor cell lines (NCI60). The large amount of biological data stored in the National Cancer Institute (NCI) database and many other databases has led researchers in the fields of computational biology and medicinal chemistry to develop tools to predict the anticancer properties of new agents in advance. In this work, based on the available antiproliferative data collected by the NCI and the manipulation of molecular descriptors, we propose the new in silico Antiproliferative Activity Predictor (AAP) tool to calculate the GI50 values of input structures against the NCI60 panel. This ligand-based protocol, validated by both internal and external sets of structures, has proven to be highly reliable and robust. The obtained GI50 values of a test set of 99 structures present an error of less than ±1 unit. The AAP is more powerful for GI50 calculation in the range of 4–6, showing that the results strictly correlate with the experimental data. The encouraging results were further supported by the examination of an in-house database of curcumin analogues that have already been studied as antiproliferative agents. The AAP tool identified several potentially active compounds, and a subsequent evaluation of a set of molecules selected by the NCI for the one-dose/five-dose antiproliferative assays confirmed the great potential of our protocol for the development of new anticancer small molecules. The integration of the AAP tool in the free web service DRUDIT provides an interesting device for the discovery and/or optimization of anticancer drugs to the medicinal chemistry community. The training set will be updated with new NCI-tested compounds to cover more chemical spaces, activities, and cell lines. Currently, the same protocol is being developed for predicting the TGI (total growth inhibition) and LC50 (median lethal concentration) parameters to estimate toxicity profiles of small molecules

Combination Antifungal Therapy for Invasive Mold Infections Among Pediatric Patients with Hematological Malignancies : Data from A Real-Life Case-Series

Background: Invasive mold infections in children with hematological malignancies are associated with high mortality rates. The use of combination antifungal therapy in cases with a severe clinical course is increasing, although information on the efficacy and safety of this approach is limited. Methods: We present a case series of 13 children affected by hemato-oncological disorders who received combination antifungal therapy for invasive mold infections at our center (Pediatric Hematology, San Gerardo Hospital, Monza, Italy) from 2011 to 2016, with the aim of describing their clinical characteristics, types of infections, treatment regimens, clinical outcomes, and treatment safety. Medical records were retrospectively reviewed in order to describe patients' characteristics. Results: Combination antifungal therapy included liposomal amphotericin associated with caspofungin (5/13, 38.4%), voriconazole (5/13, 38.4%), or posaconazole (3/13, 23.1%). The 12-week treatment response rate was 69.2% (6/13 patients showed complete response, 3/13 partial response). The crude mortality was 30.7% (4/13): half was related to invasive mold infections (2/13, 15.38%) and half to disease progression (2/13, 15.38%). Overall, treatment was well tolerated, and we did not observe any permanent discontinuation of antifungals due to related side effects. Conclusions: In our experience, combination antifungal therapy seems to be a safe option in immunocompromised children with invasive mold infections. Well-designed studies are needed to confirm the safety of this approach and to better understand its efficacy in the pediatric setting