Navon processing and verbalisation: a holistic/featural distinction

Three experiments compared face recognition performance following global and local Navon processing and verbalisation, and explored the extent to which the effects of these tasks were influenced by encoding processes. Experiment 1 used the Navon letter task at encoding, whereas Experiments 2 and 3 used personality and physical feature judgements to induce holistic and featural encoding. Accuracy and response latencies were measured for stimuli of own- and other-race faces. Results showed that both the Navon and verbal overshadowing effects were not influenced by the Navon encoding task; however, the judgement task used in Experiments 2 and 3 eliminated all impairment caused by local processing but not by providing a verbal description. These results are discussed with regards to the holistic and featural explanations of Navon processing and verbalisation effects

A Reexamination of Source Monitoring Deficits in the Elderly: Evidence for Independent Age Deficits of Item and Source Memory

Within the experimental literature there is substantial evidence of larger age-related deficits in retrieving source information relative to item-based information. However, this evidence is potentially subject to methodological criticism given that several studies have argued for the presence of source-monitoring deficits by examining source memory contingent on correct recall of item information but not the reverse. In order to address this potential shortcoming our study examines recall of both item information contingent on correct source judgement and source-based information contingent on correct recall of item information. We demonstrate that when this novel type of analysis is conducted, there are age deficits for both source and item information, and no evidence of a selectively greater source-monitoring deficit in the elderly. The results are discussed with reference to two overarching theoretical positions concerning age-related deficits in memory performance

CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival

Systemic Candida albicans infection causes high morbidity and mortality and is now the leading cause of nosocomial bloodstream infection in the United States. Neutropenia is a major risk factor for poor outcome in infected patients; however, the molecular factors that mediate neutrophil trafficking and effector function during infection are poorly defined. Using a mouse model of systemic candidiasis, we found that the neutrophil-selective CXC chemokine receptor Cxcr1 and its ligand, Cxcl5, are highly induced in the Candida-infected kidney, the target organ in the model. To investigate the role of Cxcr1 in antifungal host defense in vivo, we generated Cxcr1(-/-) mice and analyzed their immune response to Candida. Mice lacking Cxcr1 exhibited decreased survival with enhanced Candida growth in the kidney and renal failure. Increased susceptibility of Cxcr1(-/-) mice to systemic candidiasis was not due to impaired neutrophil trafficking from the blood into the infected kidney but was the result of defective killing of the fungus by neutrophils that exhibited a cell-intrinsic decrease in degranulation. In humans, the mutant CXCR1 allele CXCR1-T276 results in impaired neutrophil degranulation and fungal killing and was associated with increased risk of disseminated candidiasis in infected patients. Together, our data demonstrate a biological function for mouse Cxcr1 in vivo and indicate that CXCR1-dependent neutrophil effector function is a critical innate protective mechanism of fungal clearance and host survival in systemic candidiasis