C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis

Thermogenesis and adipogenesis are tightly regulated mechanisms that maintain lipid homeostasis and energy balance; dysfunction of these critical processes underpins obesity and contributes to cardiometabolic disease. C-type natriuretic peptide (CNP) fulfills a multimodal protective role in the cardiovascular system governing local blood flow, angiogenesis, cardiac function, and immune cell reactivity. Herein, we investigated a parallel, preservative function for CNP in coordinating metabolic homeostasis. Global inducible CNP knockout mice exhibited reduced body weight, higher temperature, lower adiposity, and greater energy expenditure in vivo. This thermogenic phenotype was associated with increased expression of uncoupling protein-1 and preferential lipid utilization by mitochondria, a switch corroborated by a corresponding diminution of insulin secretion and glucose clearance. Complementary studies in isolated murine and human adipocytes revealed that CNP exerts these metabolic regulatory actions by inhibiting sympathetic thermogenic programming via G(i)-coupled natriuretic peptide receptor (NPR)-C and reducing peroxisome proliferator-activated receptor-γ coactivator-1α expression, while concomitantly driving adipogenesis via NPR-B/protein kinase-G. Finally, we identified an association between CNP/NPR-C expression and obesity in patient samples. These findings establish a pivotal physiological role for CNP as a metabolic switch to balance energy homeostasis. Pharmacological targeting of these receptors may offer therapeutic utility in the metabolic syndrome and related cardiovascular disorders

Proposal for an Integrative Cognitive-Emotional Conception of ADHD

first_pagesettingsOrder Article Reprints Open AccessReview Proposal for an Integrative Cognitive-Emotional Conception of ADHD by Rocío Lavigne-Cerván 1ORCID,Marta Sánchez-Muñoz de León 1,Rocío Juárez-Ruiz de Mier 1,*ORCID,Marta Romero-González 1ORCID,Sara Gamboa-Ternero 2,Gemma Rodríguez-Infante 1 andJuan F. Romero-Pérez 1 1 Department of Developmental and Educational Psychology, University of Malaga, 29071 Malaga, Spain 2 Department of Developmental and Educational Psychology, University of Alicante, 03690 Alicante, Spain * Author to whom correspondence should be addressed. Int. J. Environ. Res. Public Health 2022, 19(22), 15421; https://doi.org/10.3390/ijerph192215421 Received: 23 September 2022 / Revised: 16 November 2022 / Accepted: 19 November 2022 / Published: 21 November 2022 (This article belongs to the Special Issue Emotion Regulation in Children and Adolescents) Download Browse Figure Review Reports Versions Notes Abstract Although numerous efforts have been made to deepen our understanding of the etiology of Attention Deficit Hyperactivity Disorder (ADHD), no explanation of its origins, nor of its consequences, has yet found a consensus within the scientific community. This study performs a theoretical review of various research studies and provides a reflection on the role of emotions in the origin of the disorder, at the neuroanatomical and functional level. To this end, theoretical models (single and multiple origin) and applied studies are reviewed in order to broaden the perspective on the relevance of the executive system in ADHD; it is suggested that this construct is not only composed and activated by cognitive processes and functions, but also includes elements of an emotional and motivational nature. Consequently, it is shown that ADHD is involved in social development and in a person’s ability to adapt to the environment.Partial funding for open access charge: Universidad de Málag

Crystallisation of amorphous Al-Y-Ni-(Cu) alloys

The nanocrystallisation behaviour and subsequent intermetallics formation of an amorphous Al 88 -Y 4 -Ni 8 alloy has been studied. A 1 at.% of Al or Ni was also substituted by Cu and its effect studied. Differential scanning calorimetry has been used to measure the thermal stability of these amorphous alloys. Transmission electron microscopy showed the smaller size of the nanocrystals obtained during primary crystallisation when Cu is added. Using three-dimensional atom probe, it has been checked that Cu is homogeneously distributed in the amorphous matrix, not contributing to a heterogeneous nucleation around Cu clusters during the formation of nanocrystals. Transmission electron microscopy and X-rays diffraction are used to study the controversial intermetallics occurrence at higher temperatures. The sequence and characteristics of the intermetallics appearing in these alloys were sensitive to the presence of Cu. The evolution of these intermetallics, up to 600 °C, has been studied. Findings are compared with previous studies

Crystallisation of amorphous Al-Y-Ni-(Cu) alloys

The nanocrystallisation behaviour and subsequent intermetallics formation of an amorphous Al 88 -Y 4 -Ni 8 alloy has been studied. A 1 at.% of Al or Ni was also substituted by Cu and its effect studied. Differential scanning calorimetry has been used to measure the thermal stability of these amorphous alloys. Transmission electron microscopy showed the smaller size of the nanocrystals obtained during primary crystallisation when Cu is added. Using three-dimensional atom probe, it has been checked that Cu is homogeneously distributed in the amorphous matrix, not contributing to a heterogeneous nucleation around Cu clusters during the formation of nanocrystals. Transmission electron microscopy and X-rays diffraction are used to study the controversial intermetallics occurrence at higher temperatures. The sequence and characteristics of the intermetallics appearing in these alloys were sensitive to the presence of Cu. The evolution of these intermetallics, up to 600 °C, has been studied. Findings are compared with previous studies

Abstract 13284: C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling

Abstract 13284 From the American Heart Association's 2019 Scientific Sessio