I021 Impact du polymorphisme génétique C(-260)T du CD14 sur la pression pulsée en fonction d’autres facteurs de risque cardiovasculaires : etude populationnelle transversale à partir du registre monica

Objectif de l’étudeLe CD14 est à l’intersection entre l’inflammation, les maladies infectieuses et le syndrome métabolique. Une corrélation positive entre la concentration plasmatique du CD14 soluble (sCD14) et la rigidité aortique a été décrite dans une étude transversale. Mais différents résultats ont été retrouvés sur l’incidence des évènements cardiovasculaires en fonction du polymorphisme C(-260)T du gène du CD14.L’objectif de cette étude est d’étudier l’influence du polymorphisme C(-260)T du CD14 sur la pression pulsée et indirectement sur le risque cardiovasculaire à partir de l’étude populationnelle transversale MONICA.Déroulement de l’étude1 155 sujets âgés entre 35 et 64 ans, en prévention primaire, ont été recrutés à partir des listes électorales de la Haute Garonne entre 1995 et 1997.MéthodesLa pression pulsée brachiale était mesurée au repos à 2 reprises puis moyennée. La concentration plasmatique du sCD14 a été mesurée par méthode immunoenzymatique. La randomisation est de type mendélienne. Les sujets ont été répartis en fonction du polymorphisme C(-260)T du CD14 après génotypage : homozygotes CC, homozygotes TT ou hétérozygotes CT.RésultatsLes sujets homozygotes TT ont une pression pulsée (PP) significativement plus basse et une concentration en sCD14 significativement plus élevée. Après ajustement avec les principaux facteurs confondants (âge, sexe, facteurs de risque cardiovasculaires traités), seul le génotype du CD14 reste corrélé à la PP. Cette corrélation n’intervient qu’en présence de facteurs de risque traités. Les diabétiques traités homozygotes TT sont ceux qui bénéficient de la plus importante baisse de PP par rapport aux homozygotes diabétiques CC (− 19,4mmHg, p=0,006).ConclusionCette étude suggère que les facteurs de risque ont un impact différent sur la pression pulsée en fonction du polymorphisme C(-260)T du CD14. Cette observation pourrait contribuer à affiner le risque cardiovasculaire absolu individuel, les sujets homozygotes TT ayant un risque cardiovasculaire moindre

High spatial resolution and high contrast optical speckle imaging with FASTCAM at the ORM

In this paper, we present an original observational approach, which combines, for the first time, traditional speckle imaging with image post-processing to obtain in the optical domain diffraction-limited images with high contrast (1e-5) within 0.5 to 2 arcseconds around a bright star. The post-processing step is based on wavelet filtering an has analogy with edge enhancement and high-pass filtering. Our I-band on-sky results with the 2.5-m Nordic Telescope (NOT) and the lucky imaging instrument FASTCAM show that we are able to detect L-type brown dwarf companions around a solar-type star with a contrast DI~12 at 2" and with no use of any coronographic capability, which greatly simplifies the instrumental and hardware approach. This object has been detected from the ground in J and H bands so far only with AO-assisted 8-10 m class telescopes (Gemini, Keck), although more recently detected with small-class telescopes in the K band. Discussing the advantage and disadvantage of the optical regime for the detection of faint intrinsic fluxes close to bright stars, we develop some perspectives for other fields, including the study of dense cores in globular clusters. To the best of our knowledge this is the first time that high contrast considerations are included in optical speckle imaging approach.Comment: Proceedings of SPIE conference - Ground-based and Airborne Instrumentation for Astronomy III (Conference 7735), San Diego 201

Binary frequency of planet-host stars at wide separations: A new brown dwarf companion to a planet-host star

The aim of the project is to improve our knowledge on the multiplicity of planet-host stars at wide physical separations. We cross-matched approximately 6200 square degree area of the Southern sky imaged by the Visible Infrared Survey Telescope for Astronomy (VISTA) Hemisphere Survey (VHS) with the Two Micron All Sky Survey (2MASS) to look for wide common proper motion companions to known planet-host stars. We complemented our astrometric search with photometric criteria. We confirmed spectroscopically the co-moving nature of seven sources out of 16 companion candidates and discarded eight, while the remaining one stays as a candidate. Among these new wide companions to planet-host stars, we discovered a T4.5 dwarf companion at 6.3 arcmin (~9000 au) from HIP70849, a K7V star which hosts a 9 Jupiter mass planet with an eccentric orbit. We also report two new stellar M dwarf companions to one G and one metal-rich K star. We infer stellar and substellar binary frequencies for our complete sample of 37 targets of 5.4+/-3.8% and 2.7+/-2.7% (1 sigma confidence level), respectively, for projected physical separations larger than ~60-160 au assuming the range of distances of planet-host stars (24-75 pc). These values are comparable to the frequencies of non planet-host stars. We find that the period-eccentricity trend holds with a lack of multiple systems with planets at large eccentricities (e > 0.2) for periods less than 40 days. However, the lack of planets more massive than 2.5 Jupiter masses and short periods (<40 days) orbiting single stars is not so obvious due to recent discoveries by ground-based transit surveys and space missions.Comment: Accepted for publication in A&A, 13 pages, 5 figures, 3 tables, optical spectra will be available at CDS Strasbour

Kinematics of disk galaxies in (proto-)clusters at z=1.5

We observed star-forming galaxies at z~1.5 selected from the HyperSuprimeCam Subaru Strategic Program. The galaxies are part of two significant overdensities of [OII] emitters identified via narrow-band imaging and photometric redshifts from grizy photometry. We used VLT/KMOS to carry out Halpha integral field spectroscopy of 46 galaxies in total. Ionized gas maps, star formation rates and velocity fields were derived from the Halpha emission line. We quantified morphological and kinematical asymmetries to test for potential gravitational (e.g. galaxy-galaxy) or hydrodynamical (e.g. ram-pressure) interactions. Halpha emission was detected in 36 targets. 34 of the galaxies are members of two (proto-)clusters at z=1.47, confirming our selection strategy to be highly efficient. By fitting model velocity fields to the observed ones, we determined the intrinsic maximum rotation velocity Vmax of 14 galaxies. Utilizing the luminosity-velocity (Tully-Fisher) relation, we find that these galaxies are more luminous than their local counterparts of similar mass by up to ~4 mag in the rest-frame B-band. In contrast to field galaxies at z<1, the offsets of the z~1.5 (proto-)cluster galaxies from the local Tully-Fisher relation are not correlated with their star formation rates but with the ratio between Vmax and gas velocity dispersion sigma_g. This probably reflects that, as is observed in the field at similar redshifts, fewer disks have settled to purely rotational kinematics and high Vmax/sigma_g ratios. Due to relatively low galaxy velocity dispersions (sigma_v < 400 km/s) of the (proto-)clusters, gravitational interactions likely are more efficient, resulting in higher kinematical asymmetries, than in present-day clusters. (abbr.)Comment: Accepted for publication in A&A. 11 pages, 8 figures, 1 tabl

High energy protons from PKS 1333-33

In this letter we give an account of the possible acceleration of protons in the outer radio lobes of the active galaxy PKS 1333-33. We also make estimates of the arrival energy spectrum.Comment: 3 pages revtex, two figures, to appear in Mod. Phys. Lett.

Regge calculus from a new angle

In Regge calculus space time is usually approximated by a triangulation with flat simplices. We present a formulation using simplices with constant sectional curvature adjusted to the presence of a cosmological constant. As we will show such a formulation allows to replace the length variables by 3d or 4d dihedral angles as basic variables. Moreover we will introduce a first order formulation, which in contrast to using flat simplices, does not require any constraints. These considerations could be useful for the construction of quantum gravity models with a cosmological constant.Comment: 8 page

The Line Emission Region in III Zw 2: Kinematics and Variability

We have studied the Ly-al, Hbeta, Halpha and Mg II2798 line profiles of the Seyfert 1 galaxy III Zw 2. The shapes of these broad emission lines show evidence of a multicomponent origin and also features which may be identified as the peaks due to a rotating disk. We have proposed a two-component Broad Line Region (BLR) model consisting of an inner Keplerian relativistic disk and an outer structure surrounding the disk. The results of the fitting of the four Broad Emission Lines (BELs) here considered, are highly consistent in both the inner and outer component parameters. Adopting a mass of approx. 2 E8 sollar masses for the central object we found that the outer radius of the disk is approximately equal for the four considered lines (approx 0.01 pc). However, the inner radius of the disk is not the same: 0.0018 pc for Ly-alpha, 0.0027 pc for Mg II, and 0.0038 pc for the Balmer lines. This as well as the relatively broad component present in the blue wings of the narrow [OIII] lines indicate stratification in the emission-line region. Using long-term Hbeta observations (1972-1990, 1998) we found a flux variation of the BEL with respect to the [OIII] lines.Comment: ApJ, accepted, 22 pages, 10 figure

(Broken) Gauge Symmetries and Constraints in Regge Calculus

We will examine the issue of diffeomorphism symmetry in simplicial models of (quantum) gravity, in particular for Regge calculus. We find that for a solution with curvature there do not exist exact gauge symmetries on the discrete level. Furthermore we derive a canonical formulation that exactly matches the dynamics and hence symmetries of the covariant picture. In this canonical formulation broken symmetries lead to the replacements of constraints by so--called pseudo constraints. These considerations should be taken into account in attempts to connect spin foam models, based on the Regge action, with canonical loop quantum gravity, which aims at implementing proper constraints. We will argue that the long standing problem of finding a consistent constraint algebra for discretized gravity theories is equivalent to the problem of finding an action with exact diffeomorphism symmetries. Finally we will analyze different limits in which the pseudo constraints might turn into proper constraints. This could be helpful to infer alternative discretization schemes in which the symmetries are not broken.Comment: 32 pages, 15 figure

On the properties of fractal cloud complexes

We study the physical properties derived from interstellar cloud complexes having a fractal structure. We first generate fractal clouds with a given fractal dimension and associate each clump with a maximum in the resulting density field. Then, we discuss the effect that different criteria for clump selection has on the derived global properties. We calculate the masses, sizes and average densities of the clumps as a function of the fractal dimension (D_f) and the fraction of the total mass in the form of clumps (epsilon). In general, clump mass does not fulfill a simple power law with size of the type M_cl ~ (R_cl)**(gamma), instead the power changes, from gamma ~ 3 at small sizes to gamma<3 at larger sizes. The number of clumps per logarithmic mass interval can be fitted to a power law N_cl ~ (M_cl)**(-alpha_M) in the range of relatively large masses, and the corresponding size distribution is N_cl ~ (R_cl)**(-alpha_R) at large sizes. When all the mass is forming clumps (epsilon=1) we obtain that as D_f increases from 2 to 3 alpha_M increases from ~0.3 to ~0.6 and alpha_R increases from ~1.0 to ~2.1. Comparison with observations suggests that D_f ~ 2.6 is roughly consistent with the average properties of the ISM. On the other hand, as the fraction of mass in clumps decreases (epsilon<1) alpha_M increases and alpha_R decreases. When only ~10% of the complex mass is in the form of dense clumps we obtain alpha_M ~ 1.2 for D_f=2.6 (not very different from the Salpeter value 1.35), suggesting this a likely link between the stellar initial mass function and the internal structure of molecular cloud complexes.Comment: 32 pages, 13 figures, 1 table. Accepted for publication in Ap