Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging

Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (1 = [PtCl((SOquin)dpa)], 2 = [PtCl((SOazobenz)dpa)]) containing quinoline and azobenzene appended dipicolylamine sulfonamide ligands were synthesized in good yield. The singlet attributable to methylene CH protons of the ligands of C1 and C2 appears as two doublets in H NMR spectra, which confirms the presence of magnetically nonequivalent protons upon coordination to platinum. Structural data of (SOquin)dpa (L1), (SOazobenz)dpa (L2) and PtCl((SOquin)dpa) confirmed the formation of the desired compounds. Time-dependent density functional theory calculations suggested that the excitation of L1 show quin-unit-based excitations (i.e., ligand-centered charge transfer, LC), while C1 shows the metal-ligand-to-ligand charge-transfer (MLLCT) character. L1 displays intense fluorescence from the LC excited state, while C1 gives phosphorescence from the LC state. Mammalian cell toxicity of ligands and complexes was assessed with NCI-H292 nonsmall-cell lung cancer cells. Further, C1 and C2 showed significantly low IC values compared with (SOazobenz)dpa and PtCl((SOquin)dpa). Fluorescence imaging data of both ligands and complexes revealed the potential fluorescence activity of these compounds for biological imaging. All four compounds are promising novel candidates that can be further investigated on their usage as potential anticancer agents and cancer cell imaging agents

Australian Unity Wellbeing Index survey 30.0 : The wellbeing of Australians – social media, personal achievement, and work : Report

The Australian Unity Wellbeing Index monitors the subjective wellbeing of the Australian population. Our first survey was conducted in April 2001 and this report concerns the 30th survey, undertaken in August 2013. Our previous survey had been conducted four months earlier in April. This intervening period corresponded to the 6th year of the Labor Government, elected in November 2007. Shortly after data collection, on 7th September, an election took place at which Labor lost to the Liberal Party Coalition.The share market had been stable for a couple of years, at a level well below its peak before the financial crisis. However, unemployment remained at about 5% and for those people with jobs, many were better-off financially due to cuts in interest rates, and so, in mortgage repayments.Each survey involves a telephone interview with a new sample of 2,000 Australians, selected to represent the geographic distribution of the national population. These surveys comprise the Personal Wellbeing Index, which measures people’s satisfaction with their own lives, and the National Wellbeing Index, which measures how satisfied people are with life in Australia. Other items include a standard set of demographic questions and other survey-specific questions. The specific topics for Survey 30 are social media, personal achievement, and work conditions

Australian Unity Wellbeing Index survey 28.0 : The wellbeing of Australians - The impact of marriage : Report

The Australian Unity Wellbeing Index monitors the subjective wellbeing of the Australian population.&nbsp;Our first survey was conducted in April 2001 and this report concerns the 28&nbsp;th survey, undertaken in September 2012. Our previous survey had been conducted six months earlier in April. This intervening period corresponded to the 5&nbsp;th year of the Labor Government, elected in November 2007. It was also marked by continuing apprehension at the unstable international financial situation, with serious problems in Europe. The Australian economy, however, appeared stable.&nbsp;The share market had been stable for a couple of years, at a level well below its peak before the financial crisis. However, unemployment remained at about 5% and for those people with jobs, many were better-off financially due to cuts in interest rates, and so, in mortgage repayments.&nbsp;Each survey involves a telephone interview with a new sample of 2,000 Australians, selected to represent the geographic distribution of the national population. These surveys comprise the Personal Wellbeing Index, which measures people&rsquo;s satisfaction with their own lives, and the National Wellbeing Index, which measures how satisfied people are with life in Australia. Other items include a standard set of demographic questions and other survey-specific questions. The specific topic for Survey 28 is the consequence of m on wellbeing.</div