643 research outputs found
Transient quantum evolution of 2D electrons under photoexcitation of a deep center
We have considered the ballistic propagation of the 2D electron Wigner
distribution, which is excited by an ultrashort optical pulse from a
short-range impurity into the first quantized subband of a selectively-doped
heterostructure with high mobility. Transient ionization of a deep local state
into a continuum conduction c-band state is described. Since the quantum nature
of the photoexcitation, the Wigner distribution over 2D plane appears to be an
alternating-sign function. Due to a negative contribution to the Wigner
function, the mean values (concentration, energy, and flow) demonstrate an
oscillating transient evolution in contrast to the diffusive classical regime
of propagation.Comment: 8 pages, 6 figures, pape
Magnetic field effect on tunnel ionization of deep impurities by terahertz radiation
A suppression of tunnelling ionization of deep impurities in terahertz
frequency electric fields by a magnetic field is observed. It is shown that the
ionization probability at external magnetic field, B, oriented perpendicular to
the electric field of terahertz radiation, E, is substantially smaller than
that at B || E. The effect occurs at low temperatures and high magnetic fields
Spatial structure of an individual Mn acceptor in GaAs
The wave function of a hole bound to an individual Mn acceptor in GaAs is
spatially mapped by scanning tunneling microscopy at room temperature and an
anisotropic, cross-like shape is observed. The spatial structure is compared
with that from an envelope-function, effective mass model, and from a
tight-binding model. This demonstrates that anisotropy arising from the cubic
symmetry of the GaAs crystal produces the cross-like shape for the hole
wave-function. Thus the coupling between Mn dopants in GaMnAs mediated by such
holes will be highly anisotropic.Comment: 3 figures, submitted to PR
Why and when the Minkowski's stress tensor can be used in the problem of Casimir force acting on bodies embedded in media
It is shown that the criticism by Raabe and Welsch of the
Dzyaloshinskii-Lifshitz-Pitaevskii theory of the van der Waals-Casimir forces
inside a medium is based on misunderstandings. It is explained why and at which
conditions one can use the ''Minkowski-like '' stress tensor for calculations
of the forces. The reason, why approach of Raabe and Welsch is incorrect, is
discussed.Comment: Comment, 2 pages. 2 misprints were correcte
Fast projectile stopping power of quantal multi-component strongly coupled plasmas
The Bethe-Larkin formula for the fast projectile stopping power is extended
to multi-component plasmas. The results are to contribute to the correct
interpretation of the experimental data, which could permit to test the
existing and future models of thermodynamic, static, and dynamic
characteristics of strongly coupled Coulomb systems.Comment: 4 pages, to appear in PR
Between Documentality and Imagination: Five Theses on Curating the Violent Past
This article considers the notion that to document or inscribe our lives not only leaves a trace of our creaturely presence, but may also become a form of juris-writing, a writing that concerns and aims at Justice. Employing an expanded notion of Justice that takes it beyond the institutions of law, therefore, it asks about forms of documentality (Ferraris) that put us ‘before memory’ in Derrida’s sense. How is it possible to think curation in relation to a violent past in such a way that neither attempts to deny the lacunae nor surrenders in the face of the difficulties of such attempts? How should we consider the relation between the delimited encounter with an ‘invitation to imagine’ (Didi-Huberman) and processes of institutionalisation that build a society? What about those things that it is not possible to show, including relations of power, that arise analytically? Reflecting on current memory spaces, especially within ex-clandestine centres for detention, torture and extermination (ex-ccdtyes) in Argentina, the article offers five theses in order to consider what is at stake in the encounters staged at these sites
The impact of Cochrane Systematic Reviews : a mixed method evaluation of outputs from Cochrane Review Groups supported by the UK National Institute for Health Research
© 2014 Bunn et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: There has been a growing emphasis on evidence-informed decision making in health care. Systematic reviews, such as those produced by the Cochrane Collaboration, have been a key component of this movement. The UK National Institute for Health Research (NIHR) Systematic Review Programme currently supports 20 Cochrane Review Groups (CRGs). The aim of this study was to identify the impacts of Cochrane reviews published by NIHR funded CRGs during the years 2007-11. Methods: We sent questionnaires to CRGs and review authors, interviewed guideline developers and used bibliometrics and documentary review to get an overview of CRG impact and to evaluate the impact of a sample of 60 Cochrane reviews. We used a framework with four categories (knowledge production, research targeting, informing policy development, and impact on practice/services). Results: A total of 1502 new and updated reviews were produced by the 20 NIHR funded CRGs between 2007-11. The clearest impacts were on policy with a total of 483 systematic reviews cited in 247 sets of guidance; 62 were international, 175 national (87 from the UK) and 10 local. Review authors and CRGs provided some examples of impact on practice or services, for example safer use of medication, the identification of new effective drugs or treatments and potential economic benefits through the reduction in the use of unproven or unnecessary procedures. However, such impacts are difficult to objectively document and the majority of reviewers were unsure if their review had produced specific impacts. Qualitative data suggested that Cochrane reviews often play an instrumental role in informing guidance although a poor fit with guideline scope or methods, reviews being out of date and a lack of communication between CRGs and guideline developers were barriers to their use. Conclusions: Health and economic impacts of research are generally difficult to measure. We found that to be the case with this evaluation. Impacts on knowledge production and clinical guidance were easier to identify and substantiate than those on clinical practice. Questions remain about how we define and measure impact and more work is needed to develop suitable methods for impact analysis.Peer reviewe
Barriers and facilitators to the implementation of a community-based hypertension improvement project in Ghana: a qualitative study of ComHIP.
BACKGROUND: Globally, hypertension is a leading cause of cardiovascular disease and mortality, with the majority of deaths occurring in low- and middle-income countries. Because the burden of hypertension is increasing in low resource settings with restricted infrastructure, it is imperative that new models for hypertension care are realised. One such model is the Community-based Hypertension Improvement Project (ComHIP) which employs a community-based method of task-shifting for managing hypertension. This study is a qualitative analysis of the barriers and facilitators of the main components of ComHIP. METHODS: We purposively selected 55 informants for semi-structured interviews or focus group discussions, which were carried out bythree trained local researchers in Krobo, Twi or English. Informants included patients enrolled in ComHIP, health care providers and Licensed Chemical Sellers trained by ComHIP, and Ghana Health Service employees. Data were analysed using a multi-step thematic analysis. RESULTS: While results of the effectiveness of the intervention are pending, overall, patients and nurses reported positive experiences within ComHIP, and found that it helped enable them to manage their hypertension. Healthcare providers appreciated the additional training, but had some gaps in their knowledge. Ghana Health Service employees were cautiously optimistic about the programme, but expressed some worries about the sustainability of the programme. Many informants expressed concerns over the inability of community nurses and workers to dispense anti-hypertensives, due to legal restrictions. CONCLUSIONS: The WHO recommends task-sharing as a technique for managing chronic conditions such as hypertension in resource constrained settings. ComHIP presents an example of a task-sharing programme with a high level of acceptability to all participants. Going forward, we recommend greater levels of communication and dialogue to allow community-based health workers to be allowed to dispense anti-hypertensives
Strong Attraction between Charged Spheres due to Metastable Ionized States
We report a mechanism which can lead to long range attractions between
like-charged spherical macroions, stemming from the existence of metastable
ionized states. We show that the ground state of a single highly charged
colloid plus a few excess counterions is overcharged. For the case of two
highly charged macroions in their neutralizing divalent counterion solution we
demonstrate that, in the regime of strong Coulomb coupling, the counterion
clouds are very likely to be unevenly distributed, leading to one overcharged
and one undercharged macroion. This long-living metastable configuration in
turn leads to a long range Coulomb attraction.Comment: REVTEX-published versio
Prognostic study of continuous variables (white blood cell count, peripheral blast cell count, haemoglobin level, platelet count and age) in childhood acute lymphoblastic leukaemia. Analysis of a population of 1545 children treated by the French Acute Lymphoblastic Leukaemia Group (FRALLE)
Many cutpoints have been proposed to categorize continuous variables in childhood acute lymphoblastic leukaemia (white blood cell count, peripheral blast cell count, haemoglobin level, platelet count and age), and have been used to define therapeutic subgroups. This variation in the choice of cutpoints leads to a bias called the ‘Will Rogers phenomenon’. The aim of this study was to analyse variations in the relative risk of relapse or death as a function of continuous prognostic variables in childhood ALL and to discuss the choice of cutpoints. We studied a population of 1545 children with ALL enrolled in three consecutive protocols named FRALLE 83, FRALLE 87 and FRALLE 89. We estimated the risk of relapse or death associated with different values of each continuous prognostic variable by dividing the sample into quintiles of the distribution of the variables. As regards age, a category of children under 1 year of age was distinguished and the rest of the population was divided into quintiles. The floated variance method was used to calculate the confidence interval of each relative risk, including the reference category. The relation between the quantitative prognostic factors and the risk was monotonic for each variable, except for age. For the white blood cell count (WBC), the relation is log linear. The risk associated with WBC values in the upper quintile was 1.9 times higher than that in the lower quintile. The peripheral blast cell count correlated strongly with WBC (correlation coefficient: 0.99). The risk increased with the haemoglobin level, and the risk in the upper quintile was 1.3 times higher than that in the lower quintile. The risk decreased as the platelet count increased: the risk in the lower quintile was 1.2 times higher than that in the upper quintile. The risk increased gradually with increasing age above one year. The small subgroup of patients (2.5% of the population) under 1 year of age at diagnosis had a risk 2.6 times higher than the reference category of patients between 3 and 4.3 years of age. When the risk associated with a quantitative prognostic factor varies monotonously, the selection of a cutpoint is arbitrary and represents a loss of information. Despite this loss of information, such arbitrary categorization may be necessary to define therapeutic stratification. In that case, consensus cutpoints must be defined if one wants to avoid the Will Rogers phenomenon. The cutpoints proposed by the Rome workshop and the NCI are arbitrary, but may represent an acceptable convention. © 2000 Cancer Research Campaign http://www.bjcancer.co
- …