Prevention and Treatment of Acute Stroke in the Nonagenarians and Beyond : Medical and Ethical Issues

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Shock Index Predicts up to 90-day Mortality Risk after Intracerebral Haemorrhage

ACKNOWLEDGEMENTS The following individuals should be indexed on PubMed as collaborators - VISTA-ICH Steering Committee: DF Hanley (Chair), K Butcher, S Davis, B Gregson, KR Lees, P Lyden, S Mayer, K Muir, and T SteinerPeer reviewedPostprin

An ecological study assessing the relationship between Public Health Policies and Severity of the COVID-19 Pandemic

Funding: This research received no external funding.Peer reviewedPublisher PD

Country-level determinants of the severity of the first global wave of the COVID-19 pandemic : an ecological study

Acknowledgements We would like to thank Dr Kathryn Martin, who provided valuable advice in study design. Funding This work was supported by the Aberdeen Clinical Academic Training Scheme.Peer reviewedPublisher PD

Parkinson's disease and patient related outcomes in stroke: A matched cohort study

Objective: To evaluate post-stroke outcomes in patients with Parkinson's disease (PD). Methods: A matched cohort study was performed. Stroke patients with PD and non-PD controls were extracted from the Thailand Universal Insurance Database. Logistic regressions were used to evaluate the association between PD and in-hospital outcomes (mortality and complications). The PD-associated long-term mortality was evaluated using Royston-Parmar models. Results: A total of 1967 patients with PD were identified between 2003 and 2015 and matched to controls (1:4) by age, sex, admission year, and stroke type. PD patients had decreased odds of in-hospital death: OR (95% CI) 0.66 (0.52 – 0.84) and 0.61 (0.43 – 0.85) after ischaemic and haemorrhagic strokes, respectively. PD was associated with a length-of-stay greater than median (4 days) after both stroke types: 1.37 (1.21 – 1.56) and 1.45 (1.05 – 2.00), respectively. Ischaemic stroke patients with PD also had increased odds of developing pneumonia, sepsis and AKI: 1.52 (1.2 – 1.83), 1.54 (1.16 – 2.05), and 1.33 (1.02 – 1.73). In haemorrhagic stroke patients, PD was associated with pneumonia: 1.89 (1.31 – 2.72). Survival analyses showed that PD was protective against death in the short term (HR=0.66; 95% CI 0.53–0.83 ischaemic, and HR=0.50; 95% CI 0.37 – 0.68 haemorrhagic stroke), but leads to an increased mortality risk approximately 1 and 3 months after ischaemic and haemorrhagic stroke, respectively. Conclusion: PD is associated with a reduced mortality risk during the first 2–4 weeks post-admission but an increased risk thereafter, in addition to increased odds of in-hospital complications and prolonged hospitalisation

Parkinson’s Disease and Patient Related Outcomes in Stroke : A matched cohort study

Acknowledgment The following individual should be indexed on PubMed as collaborator: North-Eastern Stroke Research Group Collaborator: Narongrit Kasemap. We gratefully acknowledge the National Health Security Office (NHSO) of Thailand for providing the data.Peer reviewedPostprin