The 2829 diseased siblings divided into deaths and survivors by disease status of the adoptee (95 adoptees deaths with infections, 827 diseased adoptees and 698 not diseased adoptees).

1<p>Age at admission with infection.</p

The 9971 siblings according to their own disease status and by disease status of the adoptee (1440 diseased adoptees and 1139 not diseased adoptees).

1<p>The diseased are hospitalized with infection or with infection as a cause of death.</p>2<p>Age at baseline in 1977.</p

Rate of hospitalization due to infectious disease and rate of death with infection among biological and adoptive siblings, in <i>predisposed</i> siblings compared to <i>non-predisposed</i>.

<p>Analyses are stratified by sex of adoptee and sibling, and by birth year group of adoptee and sibling. Siblings of the same adoptee are analysed in one model allowing for correlation between observations.</p>1<p>Siblings to an adoptee hospitalized with infection or with infection as a cause of death.</p>2<p>Siblings to an adoptee hospitalized with infection.</p>3<p>Siblings to an adoptee with infection as a cause of death.</p>4<p>Assuming additive genetic effect on the log hazard scale.</p>5<p>Assuming additive genetic effect is inappropriate.</p

The 2829 (1631+1198) diseased siblings in the analyses of case-fatality.

<p>The 2829 (1631+1198) diseased siblings in the analyses of case-fatality.</p

Flow chart illustrating the number of adoptees in the study population.

<p>Flow chart illustrating the number of adoptees in the study population.</p

Standardized Mortality Ratios in the period 1970 to 2006 of the 12,729 Danish adoptees with the general Danish population as reference.

<p>Numbers of deaths among the adoptees and gender specific SMR of all death causes combined and for deaths with infections, vascular causes, cancer, alcohol-related deaths and suicides.</p

Standardized Mortality Ratios in the period 1926 to 2006 of the 13,111 Danish adoptees with the general Danish population as reference.

<p>Numbers of deaths among the adoptees and SMR of all death causes combined in age groups and in calendar periods.</p

Flow-chart illustrating the formation of the study group by showing exclusions from the original cohort of adoptees.

<p>Flow-chart illustrating the formation of the study group by showing exclusions from the original cohort of adoptees.</p

Hazard ratio (HR) for children exposed to stress following maternal bereavement depending on different exposure status.

<p>*Adjusted for birth year, country, maternal age and origin.</p>§<p>Cases with missing exposure status: 171 for Danish males and 170 for Danish females.</p

Baseline characteristics of the study population.

<p>All the information is in n(%).</p><p>*Available from 1981 in Denmark and 1973 in Sweden.</p