2,353 research outputs found
The KELT-South Telescope
The Kilodegree Extremely Little Telescope (KELT) project is a survey for new
transiting planets around bright stars. KELT-South is a small-aperture,
wide-field automated telescope located at Sutherland, South Africa. The
telescope surveys a set of 26 degree by 26 degree fields around the southern
sky, and targets stars in the range of 8 < V < 10 mag, searching for transits
by Hot Jupiters. This paper describes the KELT-South system hardware and
software and discusses the quality of the observations. We show that KELT-South
is able to achieve the necessary photometric precision to detect transits of
Hot Jupiters around solar-type main-sequence stars.Comment: 26 pages, 13 figure
Upper-division Student Understanding of Coulomb's Law: Difficulties with Continuous Charge Distributions
Utilizing the integral expression of Coulomb's Law to determine the electric
potential from a continuous charge distribution is a canonical exercise in
Electricity and Magnetism (E&M). In this study, we use both think-aloud
interviews and responses to traditional exam questions to investigate student
difficulties with this topic at the upper-division level. Leveraging a
theoretical framework for the use of mathematics in physics, we discuss how
students activate, construct, execute and reflect on the integral form of
Coulomb's Law when solving problems with continuous charge distributions. We
present evidence that junior-level E&M students have difficulty mapping
physical systems onto the mathematical expression for the Coulomb potential.
Common challenges include difficulty expressing the difference vector in
appropriate coordinates as well as determining expressions for the differential
charge element and limits of integration for a specific charge distribution. We
discuss possible implications of these findings for future research directions
and instructional strategies.Comment: 5 pages, 1 figure, 2 tables, accepted to 2012 PERC Proceeding
ACER: A Framework on the Use of Mathematics in Upper-division Physics
At the University of Colorado Boulder, as part of our broader efforts to
transform middle- and upper-division physics courses, we research students'
difficulties with particular concepts, methods, and tools in classical
mechanics, electromagnetism, and quantum mechanics. Unsurprisingly, a number of
difficulties are related to students' use of mathematical tools (e.g.,
approximation methods). Previous work has documented a number of challenges
that students must overcome to use mathematical tools fluently in introductory
physics (e.g., mapping meaning onto mathematical symbols). We have developed a
theoretical framework to facilitate connecting students' difficulties to
challenges with specific mathematical and physical concepts. In this paper, we
motivate the need for this framework and demonstrate its utility for both
researchers and course instructors by applying it to frame results from
interview data on students' use of Taylor approximations.Comment: 10 pages, 1 figures, 2 tables, accepted to the 2012 PERC Proceeding
Possible evidence of a spontaneous spin-polarization in mesoscopic 2D electron systems
We have experimentally studied the non-equilibrium transport in low-density
clean 2D electron systems at mesoscopic length scales. At zero magnetic field
(B), a double-peak structure in the non-linear conductance was observed close
to the Fermi energy in the localized regime. From the behavior of these peaks
at non-zero B, we could associate them to the opposite spin states of the
system, indicating a spontaneous spin polarization at B = 0. Detailed
temperature and disorder dependence of the structure shows that such a
splitting is a ground state property of the low-density 2D systems.Comment: 7 pages, 5 figure
Assessing Learning Outcomes in Middle-Division Classical Mechanics: The Colorado Classical Mechanics/Math Methods Instrument
Reliable and validated assessments of introductory physics have been
instrumental in driving curricular and pedagogical reforms that lead to
improved student learning. As part of an effort to systematically improve our
sophomore-level Classical Mechanics and Math Methods course (CM 1) at CU
Boulder, we have developed a tool to assess student learning of CM 1 concepts
in the upper-division. The Colorado Classical Mechanics/Math Methods Instrument
(CCMI) builds on faculty consensus learning goals and systematic observations
of student difficulties. The result is a 9-question open-ended post-test that
probes student learning in the first half of a two-semester classical mechanics
/ math methods sequence. In this paper, we describe the design and development
of this instrument, its validation, and measurements made in classes at CU
Boulder and elsewhere.Comment: 11 pages, 6 figures, 1 tabl
Group treatments for sensitive health care problems : a randomised controlled trial of group versus individual physiotherapy sessions for female urinary incontinence
Background: The aim was to compare effectiveness of group versus individual sessions of physiotherapy in terms of symptoms, quality of life, and costs, and to investigate the effect of patient preference on uptake and outcome of treatment.
Methods: A pragmatic, multi-centre randomised controlled trial in five British National Health Service physiotherapy departments. 174 women with stress and/or urge incontinence were randomised to receive treatment from a physiotherapist delivered in a group or individual setting over three weekly sessions. Outcome were measured as Symptom Severity Index; Incontinence-related Quality of Life questionnaire; National Health Service costs, and out of pocket expenses.
Results: The majority of women expressed no preference (55%) or preference for individual treatment (36%). Treatment attendance was good, with similar attendance with both service delivery models. Overall, there were no statistically significant differences in symptom severity or quality of life outcomes between the models. Over 85% of women reported a subjective benefit of treatment, with a slightly higher rating in the individual compared with the group setting. When all health care costs were considered, average cost per patient was lower for group sessions (Mean cost difference £52.91 95%, confidence interval (£25.82 - £80.00)).
Conclusion: Indications are that whilst some women may have an initial preference for individual treatment, there are no substantial differences in the symptom, quality of life outcomes or non-attendance. Because of the significant difference in mean cost, group treatment is recommended
Magnetic Field Induced Instabilities in Localised Two-Dimensional Electron Systems
We report density dependent instabilities in the localised regime of
mesoscopic two-dimensional electron systems (2DES) with intermediate strength
of background disorder. They are manifested by strong resistance oscillations
induced by high perpendicular magnetic fields B_{\perp}. While the amplitude of
the oscillations is strongly enhanced with increasing B_{\perp}, their position
in density remains unaffected. The observation is accompanied by an unusual
behaviour of the temperature dependence of resistance and activation energies.
We suggest the interplay between a strongly interacting electron phase and the
background disorder as a possible explanation.Comment: 5 pages, 4 figure
Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers
Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,4]benzodiazepines (PBD) monomeric hybrids capable of sequence-selective inhibition of NF-κB with low nanomolar LD50 values in CLL (n=46) and MM cell lines (n=5). The lead compound, DC-1-192, significantly inhibited NF-κB DNA binding after just 4h exposure and demonstrating inhibitory effects on both canonical and non-canonical NF-κB subunits. In primary CLL cells, sensitivity to DC-1-192 was inversely correlated with RelA subunit expression (r2=0.2) and samples with BIRC3 or NOTCH1 mutations showed increased sensitivity (P=0.001). RNA-sequencing and gene set enrichment analysis confirmed the over-representation of NF-κB regulated genes in the down-regulated gene list. Furthermore, In vivo efficacy studies in NOD/SCID mice, using a systemic RPMI 8226 human multiple myeloma xenograft model, showed that DC-1-192 significantly prolonged survival (P=0.017). In addition, DC1-192 showed synergy with bortezomib and ibrutinib; synergy with ibrutinib was enhanced when CLL cells were co-cultured on CD40L-expressing fibroblasts in order to mimic the cytoprotective lymph node microenvironment (P = 0.01). Given that NF-κB plays a role in both bortezomib and ibrutinib resistance mechanisms, these data provide a strong rationale for the use of DC-1-192 in the treatment of NF-κB-driven cancers, particularly in the context of relapsed/refractory disease
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