4 research outputs found
Structural determinants and regulation of spontaneous activity in GABAA receptors
- Publication venue
- Publication date
- 01/01/2021
- Field of study
GABA_{A} receptors are vital for controlling neuronal excitability and can display significant levels of constitutive activity that contributes to tonic inhibition. However, the mechanisms underlying spontaneity are poorly understood. Here we demonstrate a strict requirement for β3 subunit incorporation into receptors for spontaneous gating, facilitated by α4, α6 and δ subunits. The crucial molecular determinant involves four amino acids (GKER) in the β3 subunit's extracellular domain, which interacts with adjacent receptor subunits to promote transition to activated, open channel conformations. Spontaneous activity is further regulated by β3 subunit phosphorylation and by allosteric modulators including neurosteroids and benzodiazepines. Promoting spontaneous activity reduced neuronal excitability, indicating that spontaneous currents will alter neural network activity. This study demonstrates how regional diversity in GABA_{A} receptor isoform, protein kinase activity, and neurosteroid levels, can impact on tonic inhibition through the modulation of spontaneous GABA_{A} receptor gating
Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer
- Author
- Abdi E.
- Abraham J.
- Abreu M.
- Adams S.
- Ademuyiwa
- Aktan G.
- Al Baghdadi T.
- Ales Martinez J. E.
- Allerton R.
- Allison M.
- Altena R.
- Anampa Mesias J. D.
- Andreopoulou E.
- Ansari B.
- Antill Y.
- Aogi K.
- Aragones A. M.
- Arahmani A.
- Armstrong A.
- Armstrong A. C.
- Armstrong D. K.
- Arnedos M.
- Arrick B. A.
- Asaad S.
- Aydogdu M.
- Baez-Diaz L.
- Bahadur S. W.
- Bakker S.
- Balmana J.
- Banuelos J. C.
- Barrett S.
- Bartsch R.
- Bear H. D.
- Bechtner C.
- Bella S.
- Bergh J.
- Bermejo de las Heras B.
- Bernardo A.
- Bertran A. S.
- Bianchini G.
- Biganzoli L.
- Blajman C.
- Bliss J.
- Boadle D.
- Bobolis K. A.
- Bonetti A.
- Bordeleau L.
- Borges V. F.
- Borley A.
- Borms M.
- Borrego M. R.
- Boyle L. E.
- Braga S.
- Brain E.
- Braybrooke J.
- Brescia F. J.
- Brufsky A. M.
- Brufsky A. M.
- Bucci E.
- Burhani N. D.
- Busch S.
- Cameron D.
- Campbell C.
- Cannon G. M.
- Canon J. -L.
- Cao M. G.
- Cardoso C.
- Cardoso F.
- Carlson J. W.
- Carney J. F.
- Carrasco F. H.
- Casa-Nova M.
- Cescon T. P.
- Chacon Lopez-Muniz J. I.
- Chae Y. S.
- Chakiba-Brugere C.
- Chalchal H.
- Chan S.
- Chang B. K.
- Chang Y. -C.
- Charles W. J.
- Chen S. -C.
- Chen S. -H.
- Chen S. -T.
- Chiu C. -F.
- Cho E. K.
- Chowdhury N.
- Chung W. -P.
- Ciccarese M.
- Ciruelos Gil E. M.
- Cobleigh M. A.
- Cole J. T.
- Colleoni M. A.
- Colleoni M. A.
- Company J. A.
- Conejero R. A.
- Conibear J.
- Constanzo M. V.
- Conte P.
- Copson E.
- Copur M. S.
- Cortesi L.
- Cortijo L. G.
- Cretella E.
- Cristofanilli M.
- Crusades G. L.
- Cui K.
- Curtit E.
- Dakhil S. R.
- Dalivoust P.
- Darsow M.
- Dayao Z. R.
- de Boer M.
- De la Haba J.
- De Laurentiis M.
- Decker T.
- Dedes K.
- Delaloge S.
- Delaloge S.
- Delgado Mingorance J. I.
- Deming R. L.
- DeNittis A. S.
- Deryal M.
- Desbiens C.
- Deveras R. A. E.
- Dewar J.
- Dewitz T.
- Dieterich M.
- Domchek S. M.
- Domchek S. M.
- Doster J. E.
- Doyle T. J.
- Duhoux F.
- Durna L. N.
- Egle D.
- Einhorn H. E.
- Eisen A.
- Eisen A.
- Eisenberg P. D.
- Ellis R.
- Elsafy F.
- Emde T. -O.
- Erdkamp F.
- Estevez L. G.
- Extra J. -M.
- Faller B. A.
- Fan Z.
- Fan Z.
- Fasching P.
- Fehm T.
- Fein L. E.
- Fein L. E.
- Ferrario C.
- Ferrero J. -M.
- Feusner J. H.
- Fielding A.
- Flaum L.
- Flynn P. J.
- Ford J. M.
- Forstmeyer D.
- Friday B. E. B.
- Friedlander M.
- Friedman S.
- Fu P.
- Fuchs D.
- Ganz P. A.
- Garber J. E.
- Garber J. E.
- Garcia Saenz J. A.
- Gayle A. A.
- Gebbia V.
- Gelber R. D.
- Gelmon K.
- Gelmon K. A.
- Gelpi J. B.
- Geng C.
- George M.
- Gerds A. T.
- Geyer C. E.
- Giacchetti S.
- Gianni L.
- Gianni L.
- Gil A.
- Gnant M.
- Gohring U. -J.
- Gomez E. A.
- Gonzalez-Santiago S.
- Goodwin A.
- Gori S.
- Grafe A.
- Graffunder G.
- Gratet A.
- Greil R.
- Grischke E. M.
- Groll I.
- Gross H. M.
- Hackmann J.
- Hahn A.
- Hahn O. M.
- Hallbeck A. -L.
- Hanson D. S.
- Harbeck N.
- Hardy-Bessard A. -C.
- Harkness C. B.
- Haslbauer F.
- Hauke R. J.
- Hayward R.
- Heibl S.
- Heijns J.
- Heinrich B.
- Helfgott R.
- Herbolsheimer P.
- Hesse T.
- Hickish T.
- Hilton C. J.
- Hoffkes H. -G.
- Hoffmann O.
- Hofstatter E. W.
- Hollingsworth S. J.
- Hoskins K. F.
- Hou M. -F.
- Huang C. -S.
- Huober J.
- Hurwitz J.
- Huynh C.
- Huzarski T.
- ido wolf
- Im S. -A.
- Im S. -A.
- Isaacs C.
- Ishida K.
- Ito M.
- Iwata H.
- Jackisch C.
- Jacot W.
- Jager A.
- Jager A.
- Janez N. M.
- Janni W.
- Jegannathen A.
- Jens-Uwe Blohmer J. S.
- Jerusalem G.
- Jiang Z.
- Jimenez M. M.
- Johannsson O.
- Johannsson O. Th.
- Jones C. A.
- Jones C. F.
- Joris S.
- Joshi A.
- Jubelirer S. J.
- Julian T. B.
- Jung K. H.
- Jung K. H.
- Jurado J. C.
- Kaen D.
- Kalinka E.
- Kalra M.
- Kannourakis G.
- Karwal M.
- Kast K.
- Kaufman B.
- Kaufman B.
- Kelleher M.
- Khosla P. G.
- Kim J. H.
- Kinoshita T.
- Klare P.
- Kolberg H. -C.
- Korde L.
- Krabisch P.
- Kroep J.
- Kuhn T.
- Kummel S.
- Kurian S.
- Kuzma C. S.
- L'Haridon T.
- Lakhani S. R.
- Lambiase E. A.
- Landherr L.
- Lanza A. A.
- Lazzaro M. F.
- Ledwon P.
- Lee K. E.
- Lee K. S.
- Lerzo G.
- Lescure A. R.
- Leu K. M. H.
- Levine E. A.
- Levitt N.
- Levy C.
- Liao N.
- Linderholm B.
- Linderholm B.
- Liu T. -W.
- Lo S. S.
- Loibl S.
- Loman N.
- Loman N.
- Lopez I. A.
- Lortholary A.
- Lu M. J.
- Lucas P. C.
- Luce S.
- Mackey J.
- Mackiewicz J.
- Mahtani R. L.
- Mailliez A.
- Mailliez A.
- Mansoor A. H.
- Marchello T B.
- Marcom P. K.
- Marme F.
- Martinez de Duenas E.
- Martinez de Duenas E.
- Martinez L. C.
- Masuda N.
- Mau C.
- McCarron E. C.
- McCarthy N.
- McConnell R.
- Mege A.
- Meisel J. L.
- Menter A.
- Merkel D. E.
- Mita M. M.
- Molins A. B.
- Mosconi A. M.
- Mouret-Reynier M. -A.
- Mukai H.
- Muller V.
- Murillo S. M.
- Murray N.
- Nagy T.
- Nagy T.
- Nakamura R.
- Nakamura S.
- Nakayama T.
- Nangia J. R.
- Naoi Y.
- Nave M.
- Neven P.
- Niraula S.
- Noeding S.
- Noesselt T.
- Novak U.
- Nowecki Z.
- O'Connor B. M.
- Ochoa A. C.
- Ofori S. N.
- Ohler L.
- Olabisi F.
- Oliff I. A.
- Openshaw T. H.
- Ortega A. F.
- Ortega A. L.
- Osaki A.
- Padro J. G.
- Paepke S.
- Pang D.
- Pang D.
- Papadimitriou K.
- Park Y. H.
- Park Y. H.
- Park-Simon T. -W.
- Parton M.
- Parton M.
- Pasterk C.
- Patel T.
- Patocskai E.
- Penzinger M.
- Perren T.
- Perrin C.
- Petit T.
- Phillips K. -A.
- Piccart M.
- Pilnik N.
- Pinotti G.
- Polikoff J. A.
- Potenberg J.
- Pottier V.
- Prady C.
- Pristauz-Telsnigg G.
- Puthillath A.
- Qamar R.
- Quaghebeur C.
- Quiroga V.
- Raben A.
- Radford J. E.
- Rai Y.
- Ramaswamy B.
- Randal d'Hondt
- Rastogi P.
- Rautenberg B.
- Razaq W.
- Razaq W.
- Rea D.
- Reeder J. G.
- Rhiem K.
- Riseberg D. A.
- Robin E. L.
- Rodriguez C.
- Rohatgi N.
- Rom J.
- Roodenbeke D. T. D.
- Ross L.
- Rossi G.
- Rovito M. A.
- Roylance R.
- Ruddy K. J.
- Ruggeri E. M.
- Rumpold H.
- Ryan M. L.
- Salat C.
- Salkeni M. A.
- Sami A.
- Santisteban M.
- Sarosiek T.
- Sato N.
- Schallenkamp J.
- Schmatloch S.
- Schmidt M.
- Schmidt M.
- Schmutzler R.
- Schott A. F.
- Schreiber C.
- Seaward S. A.
- Seeger G. R.
- Senkus E.
- Senkus E.
- Sevelda P.
- Shao Z.
- Shao Z.
- Sharma P.
- Sharma P.
- Sharma R.
- Shen K.
- Shenk R. R.
- Siegel R. D.
- Siggelkow W.
- Sigurdson E. R.
- Silander G.
- Simon H.
- Simon M. S.
- Singer C. F.
- Singer C. F.
- Singh J.
- Slowinska A.
- Smith R.
- Sohn J. H.
- Song C.
- Sonke G. S.
- Sonke G. S.
- Soori G. S.
- Spanic T.
- Specht J. M.
- Spector D. M.
- Steen P. D.
- Stefek A.
- Stickeler E.
- Stickeler E.
- Stockham A.
- Stoger H.
- Storniolo A. M. V.
- Strasser-Weippl K.
- Suga J. M.
- Sugimoto T.
- Sui X.
- Sumida K. N. M.
- Sumrall B. T.
- Sun Q.
- Sun Q.
- Taboada M.
- Takada M.
- Takahashi M.
- Takano T.
- Tan A. R.
- Tato-Varela S.
- Telli M. L.
- Tennevet I.
- Tennevet I.
- Terhaag J.
- Thiel I.
- Thomalla J.
- Thomssen C.
- Tiley S.
- Tinchon C.
- Tio J.
- Tkaczuk K. H. R.
- Toi M.
- Tokuda Y.
- Tokunaga E.
- Tome O.
- Tondini C.
- Toppmeyer D. L.
- Tormo S. B.
- Torres A. A.
- Toyama T.
- Traina T. A.
- Tredan O.
- Trehan S.
- Tseng L. -M.
- Tsugawa K.
- Tutt A.
- Tutt A. N. J.
- Uleer C.
- Unnikrishnan M.
- Urquhart A. T.
- Uziely B.
- Vachhani H.
- Vakhariya C. M.
- Valdes-Albini F.
- van der Westhuizen A.
- van Haelst C. M.
- VanderWoude A.
- Varadarajan R.
- Varela M.
- Venat-Bouvet L.
- Verusio C.
- Viale G.
- Villaro G. V.
- Virani S.
- Vogel V. G.
- von Wachenfeldt Vappling A.
- Wade J. L.
- Wagner H.
- Waisman J.
- Wang S.
- Wang Y.
- Watanabe J.
- Weigel M.
- Weltermann A.
- Weniger S.
- Wette V.
- Wilbur D. W.
- Wilkinson M.
- Winter M.
- Wolf Sutterlin M.
- Wong D.
- Wong L.
- Wood M. E.
- Woodward N.
- Wullner M. P.
- Xu B.
- Yamauchi H.
- Yan F.
- Yanagita Y.
- Yang H.
- Yang H.
- Yeh D. -C.
- Yerushalmi R.
- Yerushalmi R.
- Yothers G.
- Yu J. -C.
- Zahm D.
- Zakalik D.
- Zamagni C.
- Zaman K.
- Zarba J. J.
- Zera R. T.
- Zhang J.
- Zhang J.
- Zheng H.
- Zhuo Y.
- Zimbler H.
- Zoppoli G.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive disease-free survival (IDFS) and distant disease-free survival (DDFS). The olaparib group had fewer deaths than the placebo group, but the difference did not reach statistical significance for overall survival (OS). We now report the pre-specified second IA of OS with updates of IDFS, DDFS, and safety. Patients and methods: One thousand eight hundred and thirty-six patients were randomly assigned to olaparib or placebo following (neo)adjuvant chemotherapy, surgery, and radiation therapy if indicated. Endocrine therapy was given concurrently with study medication for hormone receptor-positive cancers. Statistical significance for OS at this IA required P < 0.015. Results: With a median follow-up of 3.5 years, the second IA of OS demonstrated significant improvement in the olaparib group relative to the placebo group [hazard ratio 0.68; 98.5% confidence interval (CI) 0.47-0.97; P = 0.009]. Four-year OS was 89.8% in the olaparib group and 86.4% in the placebo group (Δ 3.4%, 95% CI -0.1% to 6.8%). Four-year IDFS for the olaparib group versus placebo group was 82.7% versus 75.4% (Δ 7.3%, 95% CI 3.0% to 11.5%) and 4-year DDFS was 86.5% versus 79.1% (Δ 7.4%, 95% CI 3.6% to 11.3%), respectively. Subset analyses for OS, IDFS, and DDFS demonstrated benefit across major subgroups. No new safety signals were identified including no new cases of acute myeloid leukemia or myelodysplastic syndrome. Conclusion: With 3.5 years of median follow-up, OlympiA demonstrates statistically significant improvement in OS with adjuvant olaparib compared with placebo for gBRCA1/2pv-associated EBC and maintained improvements in the previously reported, statistically significant endpoints of IDFS and DDFS with no new safety signals
Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer
- Author
- Abdi Ehtesham
- Abraham Jean
- Abreu Miguel
- Adams Sylvia
- Aktan G.
- Al Baghdadi Tareq
- Allerton Rozenn
- Allison Magnuson
- Altena Renske
- Alés Martínez Jose Enrique
- Anampa Mesias Jesus
- Andreopoulou Eleni
- Ansari Bilal
- Antill Yoland
- Aogi Kenjiro
- Aragones Antonia Marquez
- Arahmani A.
- Armstrong A.C.
- Armstrong Anne
- Armstrong Deborah
- Armstrong Deborah
- Arnedos M.
- Arrick Bradley
- Asaad Shonda
- Aydogdu Mustafa
- Baez-Diaz Luis
- Bahadur Shakeela
- Bakker Sandra
- Balmaña J.
- Barrett Sophie
- Bartsch Rupert
- Bañuelos Juan Cueva
- Bear Harry
- Bechtner Christina
- Bella Santiago
- Bergh J.
- Bermejo de las Heras Begoña
- Bernardo Antonio
- Bertrán Ana Santaballa
- Bianchini Giampaolo
- Biganzoli Laura
- Blajman Cesar
- Bliss J.
- Boadle David
- Bobolis Kristie
- Bonetti Andrea
- Bordeleau Louise
- Borges Virginia
- Borley Annabel
- Borms Marleen
- Borrego Manuel Ruiz
- Boyle L.E.
- Braga Sofia
- Brain Etienne
- Braybrooke Jeremy
- Brescia Frank
- Brufsky A.M.
- Brufsky Adam
- Bucci Eraldo
- Burhani Nafisa
- Busch Steffi
- Cameron D.
- Campbell C.
- Cannon George
- Cannon George
- Canon Jean-Luc
- Cao María González
- Cardoso Catarina
- Cardoso Fátima
- Carlson Jay
- Carlson Jay
- Carney Jennifer Fu
- Carrasco Fernando Henao
- Casa-Nova Mafalda
- Cescon Terrence
- Chacón López-Muñiz José Ignacio
- Chae Yee Soo
- Chakiba-Brugere Camille
- Chalchal Haji
- Chan Stephen
- Chang Brian
- Chang Yuan-Ching
- Charles William
- Chen Shang-Hung
- Chen Shin-Cheh
- Chen Shou-Tung
- Chiu Chang-Fang
- Cho Eun Kyung
- Chowdhury Nabila
- Chung Wei-Pang
- Ciccarese Mariangela
- Ciruelos Gil Eva María
- Cobleigh Melody
- Cole John
- Cole John
- Cole John
- Cole John
- Colleoni M.A.
- Colleoni Marco
- Company Jesús Alarcon
- Conejero Raquel Andrés
- Conibear John
- Constanzo Maria Victoria
- Conte Pierfranco
- Copson Ellen
- Copur Mehmet
- Cortesi Laura
- Cortijo Lucía González
- Cretella Elisabetta
- Cristofanilli Massimo
- Crusades Gema Llort
- Cui K.
- Curtit Elsa
- Dakhil Shaker
- Dakhil Shaker
- Dalivoust Philippe
- Darsow Maren
- Dayao Zoneddy
- de Boer Maaike
- de la Haba Juan
- de Laurentiis Michelino
- Decker Thomas
- Dedes Konstantin
- Delaloge S.
- Delaloge Suzette
- Delgado Mingorance Juan Ignacio
- Deming Richard
- Denittis Albert
- Deryal Mustafa
- Desbiens Christine
- Deveras Ruby Anne E.
- Dewar Joanna
- Dewitz Thomas
- Dieterich Max
- Domchek S.M.
- Domchek Susan
- Doster John
- Doyle Thomas
- Duhoux François
- Durna Lara
- Egle Daniel
- Einhorn Harvey
- Eisen A.
- Eisen Andrea
- Eisenberg Peter
- Ellis Robert
- Elsafy F.
- Emde Till-Oliver
- Erdkamp Franciscus
- Estevez Laura García
- Extra Jean-Marc
- Faller Bryan
- Fan Z.
- Fan Zhimin
- Fasching Peter
- Fehm Tanja
- Fein L.E.
- Fein Luis
- Ferrario Cristiano
- Ferrero Jean-Marc
- Feusner James
- Fielding A.
- Flaum Lisa
- Flynn Patrick
- Flynn Patrick
- Ford J.M.
- Forstmeyer Dirk
- Friday Bret E.B.
- Friedlander Michael
- Friedman S.
- Fu Peifen
- Fuchs David
- Ganz Patricia
- Garber J.E.
- Garber Judy
- Garber Judy
- García Sáenz José Ángel
- Gayle Arlene
- Gebbia Vittorio
- Gelber R.D.
- Gelmon K.A.
- Gelmon Karen
- Gelpi Judith Balmaña
- Geng Cuizhi
- George Mathew
- Gerds Aaron
- Geyer C.E.
- Giacchetti Sylvie
- Gianni L.
- Gianni Lorenzo
- Gil Amaryllis
- Gnant M.
- Gomez Elena Álvarez
- González-Santiago Santiago
- Goodwin Annabel
- Gori Stefania
- Grafe Andrea
- Graffunder Gerd
- Gratet Alain
- Greil Richard
- Grischke Eva Maria
- Gross Howard
- Gross Howard
- Gross Howard
- Gross Howard
- Gross Howard
- Gröll Isolde
- Göhring Uwe-Jochen
- Hackmann John
- Hahn Antje
- Hahn Olwen
- Hallbeck Anna-Lotta
- Hanson David
- Harbeck Nadia
- Hardy-Bessard Anne-Claire
- Harkness Cameron
- Haslbauer Ferdinand
- Hauke Ralph
- Hauke Ralph
- Hayward Richard
- Heibl Sonja
- Heijns Joan
- Heinrich Bernhard
- Helfgott Ruth
- Herbolsheimer Pia
- Hesse Tobias
- Hickish Tamas
- Hilton Christie
- Hoffmann Oliver
- Hofstatter Erin
- Hofstatter Erin
- Hofstatter Erin
- Hollingsworth S.J.
- Hoskins Kent
- Hou Ming-Feng
- Huang Chiun-Sheng
- Huober Jens
- Hurwitz Jane
- Huynh Chanh
- Huzarski Tomasz
- Höffkes Heinz-Gert
- Im S.-A.
- Im Seock-Ah
- Isaacs Claudine
- Ishida Kazushige
- Ito Mitsuya
- Iwata Hiroji
- Jackisch Christian
- Jacot William
- Jager A.
- Jager Agnes
- Janni W.
- Jañez Noelia Martínez
- Jegannathen Apurna
- Jens-Uwe Blohmer Jan Schröder
- Jerusalem Guy
- Jiang Zefei
- Jiménez Miguel Martín
- Johannsson Oskar
- Jones Catherine
- Jones Cheryl
- Joris Sofie
- Joshi Abhishek
- Jubelirer Steven
- Julian Thomas
- Jung K.H.
- Jung Kyung Hae
- Jurado Josefina Cruz
- Jóhannsson Ó. Þ
- Kaen Diego
- Kalinka Ewa
- Kalra Maitri
- Kannourakis George
- Karwal Mark
- Kast Karin
- Kaufman B.
- Kaufman Bella
- Kelleher Muireann
- Khosla Pam
- Kim Jee Hyun
- Kinoshita Takayuki
- Klare Peter
- Kolberg Hans-Christian
- Korde L.
- Krabisch Petra
- Kroep Judith
- Kurian Sobha
- Kuzma Charles
- Kühn Thorsten
- Kümmel Sherko
- Kümmel Sherko
- l'Haridon Tiffenn
- Lakhani S.R.
- Lambiase Elyse
- Landherr László
- Lanza Angels Arcusa
- Lazzaro Mauricio Fernández
- Ledwon Peter
- Lee Keun Seok
- Lee Kyoung Eun
- Lerzo Guillermo
- Lescure Álvaro Rodríguez
- Leu Kirsten M.H.
- Levine Edward
- Levitt Nicola
- Liao Ning
- Linderholm B.
- Linderholm Barbro
- Liu T.-W.
- Lo Shelly
- Loibl S.
- Loman N.
- Loman Niklas
- Lortholary Alain
- Lu Min
- Lu Min
- Lucas P.C.
- Luce Sylvie
- Lévy Christelle
- López Isabel Álvarez
- Mackey John
- Mackiewicz Jacek
- Mahtani Reshma
- Mahtani Reshma
- Mailliez A.
- Mailliez Audrey
- Mansoor Abdul
- Marcom Paul
- Marmé F.
- Martinez de Dueñas E.
- Martinez Lourdes Calvo
- Martínez de Dueñas Eduardo
- Masuda Norikazu
- Mau Christine
- Mccarron Edward
- Mccarthy Nicole
- Mcconnell R.
- Mege Alice
- Meisel Jane
- Menter Alex
- Merkel Douglas
- Mita Monica
- Molins Agusti Barnadas
- Mosconi Anna Maria
- Mouret-Reynier Marie-Ange
- Mukai Hirofumi
- Murillo Serafín Morales
- Murray Nicholas
- Müller Volkmar
- Nagy T.
- Nagy Tünde
- Nakamura Rikiya
- Nakamura Seigo
- Nakayama Takahiro
- Nangia Julie
- Naoi Yasuto
- Nave Mónica
- Neven Patrick
- Niraula Saroj
- Noeding Stefanie
- Noesselt Thomas
- Novak Urban
- Nowecki Zbigniew
- O'Connor Brian
- Ochoa Augusto
- Ochoa Augusto
- Ofori Samuel
- Olabisi Foluso
- Oliff Ira
- Openshaw Thomas
- Openshaw Thomas
- Openshaw Thomas
- Ortega Adela Fernández
- Ortega Ana Laura
- Osaki Akihiko
- Padró Josep Gumà
- Paepke Stefan
- Pang D.
- Pang Da
- Papadimitriou Konstantinos
- Park Y.H.
- Park Yeon Hee
- Park-Simon Tjoung-Won
- Parton M.
- Parton Marina
- Pasterk Claudia
- Patel Tejal
- Patocskai Erica
- Penzinger Monika
- Perren Timothy
- Perrin Christophe
- Petit Thierry
- Phillips K.-A.
- Phillips Kelly-Anne
- Piccart M.
- Pilnik Norma
- Pinotti Graziella
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Potenberg Jochem
- Pottier Virginie
- Prady Catherine
- Pristauz-Telsnigg Gunda
- Puthillath Ajithkumar
- Qamar Rubina
- Qamar Rubina
- Qamar Rubina
- Qamar Rubina
- Quaghebeur Claire
- Quiroga Vanesa
- Raben Adam
- Radford James
- Rai Yoshiaki
- Ramaswamy Bhuvaneswari
- Rastogi P.
- Rautenberg Beate
- Razaq W.
- Razaq Wajeeha
- Rea Daniel
- Reeder Jennifer
- Rhiem Kerstin
- Riseberg David
- Robin Erwin
- Rodríguez César
- Rohatgi Nitin
- Rom Joachim
- Roodenbeke Daphné T’kint De
- Ross L.
- Rossi G.
- Rovito Marc
- Roylance Rebecca
- Ruddy Kathryn
- Ruggeri Enzo Maria
- Rumpold Holger
- Ryan Matthew
- Salat Christoph
- Salkeni Mohamad
- Sami Amer
- Santisteban Marta
- Sarosiek Tomasz
- Sato Nobuaki
- Schallenkamp John
- Schmatloch Sabine
- Schmidt M.
- Schmidt Marcus
- Schmutzler R.
- Schott Anne
- Schreiber Carsten
- Seaward Samantha
- Seaward Samantha
- Seeger Grant
- Senkus E.
- Senkus Elżbieta
- Sevelda Paul
- Shao Z.
- Shao Zhimin
- Sharma P.
- Sharma Priyanka
- Sharma Ruby
- Shen Kunwei
- Shenk Robert
- Shenk Robert
- Shenk Robert
- Siegel Robert
- Siggelkow Wulf
- Sigurdson Elin
- Silander Gustav
- Simon Hélène
- Simon Michael
- Singer C.F.
- Singer Christian
- Smith Ron
- Sohn Joo Hyuk
- Song Chuangui
- Sonke G.S.
- Sonke Gabe
- Soori Gamini
- Specht Jennifer
- Spector David
- Steen Preston
- Stefek Andrea
- Stickeler E.
- Stickeler Elmar
- Stockham Abigail
- Storniolo Anna M.V.
- Strasser-Weippl Kathrin
- Stöger Herbert
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Sugimoto Takeki
- Sui Xingwei
- Sumida Kenneth N.M.
- Sumida Kenneth N.M.
- Sumrall Bradley
- Sun Q.
- Sun Qiang
- Słowińska Anna
- T Benjamin
- Taboada M.
- Takada Masahiro
- Takahashi Masato
- Takano Toshimi
- Tan Antoinette
- Tato-Varela Sara
- Telli Melinda
- Tennevet I.
- Tennevet Isabelle
- Terhaag Jürgen
- Thiel Irene
- Thomalla Jörg
- Thomssen Christoph
- Tiley Susan
- Tinchon Christoph
- Tio Joke
- Tkaczuk Katherine H.R.
- Toi M.
- Tokuda Yutaka
- Tokunaga Eriko
- Tomé Oliver
- Tondini Carlo
- Toppmeyer Deborah
- Tormo Salvador Blanch
- Torres Antonio Antón
- Toyama Tatsuya
- Traina T.A.
- Tredan Olivier
- Trehan Shruti
- Tseng Ling-Ming
- Tsugawa Koichiro
- Tutt A.N.J.
- Tutt Andrew
- Uleer Christoph
- Unnikrishnan Madhu
- Urquhart Alexander
- Uziely Beatrice
- Vachhani Hetal
- Vakhariya Cynthia
- Valdes-Albini Frances
- van der Westhuizen Andre
- van Haelst Carol
- Vanderwoude Amy
- Varadarajan Ramya
- Varela Mirta
- Venat-Bouvet Laurence
- Verusio Claudio
- Viale G.
- Villaró Gemma Viñas
- Virani Shamsuddin
- Vogel Victor
- von Wachenfeldt Väppling Anna
- Wade James
- Wade James
- Wagner Harald
- Waisman James
- Wang Shui
- Wang Yongsheng
- Watanabe Junichiro
- Weigel Michael
- Weltermann Angsar
- Weniger Steffi
- Wette Viktor
- Wilbur Deborah
- Wilkinson Mary
- Winter Matthew
- Wolf Sütterlin Marc
- Wong Derrick
- Wong Lucas
- Wood Marie
- Wood Marie
- Woodward Natasha
- Wüllner Michaela Penelope
- Xu Binghe
- Yamauchi Hideko
- Yan Fengting
- Yanagita Yasuhiro
- Yang H.
- Yang Hongjian
- Yeh Dah-Cherng
- Yerushalmi R.
- Yerushalmi Rinat
- Yothers G.
- Yu Jyh-Cherng
- Zahm Dirk
- Zakalik Dana
- Zamagni Claudio
- Zaman Khalil
- Zarba Juan Jose
- Zera Richard
- Zera Richard
- Zhang J.
- Zhang Jin
- Zheng Hong
- Zhuo Ying
- Zimbler Harvey
- Zoppoli G.
- Öhler Leopold
- Španić T.
- Publication venue
- Elsevier
- Publication date
- 01/12/2022
- Field of study
International audienc
Literatur
- Author
- Bellinger Krieger
- Berg Christian
- Berger-Künzli Daniela
- Bergmann Sigurd
- Berlejung Angelika
- Bermes Christian
- Bernhard Jutta
- Berressem Hanjo
- Bessler Gabriele
- Biehl Peter
- Bieritz Karl-Heinrich
- Blumenberg Hans
- Blumenberg Hans
- Blumenberg Hans
- Blumenberg Hans
- Boehm Gottfried
- Bogner Daniel
- Bogner Daniel
- Boneberg Hemma
- Bourdieu
- Bourdieu Pierre
- Brockert Heinz
- Brämer Rainer
- Bumchter Inhetveen
- Burckhard Martin
- Busch Werner
- Busch Werner
- Busche-Baumann Maria
- Bçhme Bçhme
- Bçhme Gernot
- Bçhme Gernot
- Bçhme Hartmut
- Bçhme Hartmut
- Bçhme Hartmut
- Bçhme Hartmut
- Bçhme Hartmut
- Bçhmer Gerhard
- Bçrsch-Supan Helmut
- Calvin Johannes
- Certeau ündende Bruch
- Certeau ündende Bruch
- Chatelier Hildegard
- Cicero
- Cilliers Johannes H
- Coblenz Catharina
- Colpe Carsten
- Corbin Alain
- Cramer Konrad
- Csikszentmihalyi Jackson
- Csikszentmihalyi Mihaly
- Dafni Evangelia G
- Dahm Karl-Wilhelm
- Daiber Jürgen
- Daiber Karl-Fritz
- Danks Fiona
- Dannowski Hans
- Dawkins Richard
- Dei Filius
- der Hölle
- Der Laubenkolonist Zeitschrift
- der Nordseeküste „enorm
- Der Sonntag
- Deutscher Jagdschutz-Verband
- Dickel Heinrich
- Dietrich Isolde
- Dirlinger Helga
- Dittmar Dittmar
- Dittmer Johannes Michael
- Dohmen Christoph
- Domay Erhard
- Draesner Ulrike
- Drees Willem B
- Drewen Uwe
- Drews Paul
- Drews Paul
- Drews Paul
- Drews Paul
- Drews Paul
- Drouve Andreas
- Dyrness William A
- Dçring Thielmann
- Dülmen
- Dürr Zimmerli
- Eickhoff Georg
- Eliade Mircea
- Ellsiepen Christof
- Engemann Wilfried
- Erasmus von Rotterdam Desiderius
- Ev
- Failing Wolf-Eckart
- Fechtner Kristian
- Flick Uwe
- Flusser Villem
- Forschungsliteratur
- Foucault Michel
- Foucault Michel
- Foucault Michel
- Foucault Michel
- Frank Günter
- Frank Günter
- Freizeit
- Friedman Goldworthy
- Friedrich Marcus A
- Gamm Gutmann
- Gansterer Gerhard
- Gebhard Ulrich
- Geertz Clifford
- Geertz Clifford
- Genette GØrard
- Gennep Übergangsriten
- Gese Hartmut
- Gestrich Christoph
- Giddens Anthony
- Gladigow Burkhard
- Gladigow Burkhard
- Glaser Hermann
- Gottowik Viktor
- Graf Friedrich-Wilhelm
- Green Walter
- Gregersen Niels Henrik
- Grethlein Christian
- Grethlein Christian
- Grevel Jan
- Grevel Jan
- Grevel Jan Peter
- Grevel Jan Peter
- Groh Groh
- Groh Groh
- Grohmann Marianne
- Grossklaus Oldemeyer
- Gräb Herrmann
- Gräb Wilhelm
- Gräb Wilhelm
- Gräb Wilhelm
- Gräb-Schmidt Elisabeth
- Grçzinger Albrecht
- Grçzinger Albrecht
- Grçzinger Albrecht
- Grçzinger Albrecht
- Grçzinger Albrecht
- Grçzinger Mauz
- Gunkel Hermann
- Guschker Stefan
- Gyr Ueli
- Günzel Stephan
- Günzel Stephan
- Güthler Lacher
- Habermas Jürgen
- Habermas Jürgen
- Habermas Jürgen
- Habermas Jürgen
- Hack Kerstin
- Haid Hans
- Hamann Johann Georg
- Hansen Kai
- Harrington Anne
- Hartig Nina
- Hartinger Walter
- Hasel Verena Friederike
- Hasler Ueli
- Haudebourg Marie-ThØrese
- Hecht Herbert
- Hecker Hecker
- Heckmann Herbert
- Heimbrock Failing
- Heimbrock Failing
- Heimbrock Failing
- Heimbrock Hans-Günter
- Heimbrock Hans-Günter
- Heimbrock Hans-Günter
- Heimbrock Hans-Günter
- Heimbrock Hans-Günter
- Heimbrock Hans-Günter
- Heimbrock Hans-Günter
- Heimbrock Hans-Günter
- Heimbrock Meyer
- Heimbrock Scholz
- Heimbrock Wyller
- Heine
- Heit Alexander
- Henner Margit Leuthold
- Herding Klaus
- Herlyn Okko
- Hermelink Jan
- Herms Eilert
- Herrmann Jçrg
- Hg Energiediskussion
- Hg Energiediskussion
- Hinrichsen Alex
- Hitzler Eberle
- Hofman Werner
- Honneth Axel
- Hopf Christel
- Hoppe Rudolf
- Horatschek Annegreth
- Hornig Gottfried
- Huizing Klaas
- Hunze Feeser
- Hunze Guido
- Husserl Edmund
- Husserl Edmund
- Hägele Ulrich
- Hägele Ziehe
- Hçhn Hans-Joachim
- Hçrisch Jochen
- Hübner Jürgen
- Ilschner Frank
- Immanuel Kant
- Immanuel Kant
- Immanuel Kant
- Ingrid Lukatis Lukatis
- Janowski Bernd
- Jensen Jens Christian
- Jensen Uffa
- Jäger Siegfried
- Jäger Siegfried
- Jäger Siegfried
- Jäger Ulle
- Jähnig Karl Wilhelm
- Jçchner Cornelia
- Jçrns Klaus-Peter
- Jüngel Eberhard
- Kalberer Remann
- Karahasan Dzevad
- Kauppert Funcke
- Keel Ottmar
- Keel Schroer
- Keller Reiner
- Keller Susanne B
- Kirsner Wermke
- Klein Stephanie
- Klessmann Michael
- Klie Korsch
- Klie Thomas
- Klie Thomas
- Klie Thomas
- Klingbeil Almut
- Klinger Cornelia
- Knoblauch Hubert
- Koch Klaus
- Kock Christoph
- Koerner Joseph Leo
- Kopp Eduard
- Koschorke Albrecht
- Koselleck Reinhart
- Krauss Heinrich
- Krech Volkhard
- Kress Volker
- Kress Volker
- Kress Volker
- Kriechbaum Wilhelm
- Krämer Sybille
- Krçner Magdalena
- Kubick Andreas
- Kçrtner Ulrich H.J.
- Küster Hans-Jçrg
- Küster Hansjçrg
- Lammer Eugen Guido
- Lange Ernst
- Lauterbach Christiane
- Lehmann Albrecht
- Leithäuser Johannes
- Leithäuser Johannes
- Levi-Strauss Claude
- Levine Michael P
- Lichtenberg Georg Christoph
- Liedke Gerhard
- Link Christian
- Link Christian
- Link Christian
- Lohse Eckart
- Loudon J. C.
- Louvs Richard
- Ludolphy Ingetraut
- Luhmann Niklas
- Luther Henning
- Luther Henning
- Lynd Robert
- LØvinas Emmanuel
- Lübbe Hermann
- Lüders Meuser
- Maier Büchner
- Majetschak Stefan
- Mallek Ulf
- Margueron Jean-Claude
- Markus Heike
- Marquard Odo
- Marschner Jçrg
- Marschner Jçrg
- Marschner Jçrg
- Maslow Abraham H
- Mathis Claudia
- Matthes Joachim
- Matthäi Ingrid
- Mayer Michael
- Mayer-Tasch Peter Cornelius
- Mayr Vincent
- Mayring Philipp
- McGrath Alister
- McLuhan Marshall
- McMullin Ernan
- Meckenstock Günter
- Meid Volker
- Meier Christian
- Melanchthon Philipp
- Menasse Eva
- Merle Kristin
- Merleau-Ponty Maurice
- Merleau-Ponty Maurice
- Merleau-Ponty Maurice
- Meyer-Abich Klaus Michael
- Meyer-Abich Klaus Michael
- Meyer-Abich Klaus Michael
- Meyer-Abich Klaus Michael
- Meyer-Abich Klaus Michael
- Meyer-Abich Klaus Michael
- Meyer-Abich Klaus Michael
- Meyer-Blanck Michael
- Meyer-Blanck Michael
- Miller Otto
- Moltmann Jürgen
- Moltmann Jürgen
- Moltmann Jürgen
- Moltmann Wendel Elisabeth
- Morgenroth Matthias
- Morgenroth Matthias
- Morgentahler Christoph
- Moustakas Ulrich
- Munz Regine
- Mutschler Hans D
- Mçhring Caroline
- Mçnch Regina
- Müller Hans-Peter
- Müller Manfred
- Müller Wolfgang G
- Müller-Bahlke Thomas J
- Müller-Doohm Stefan
- Müller-Doohm Stefan
- Müller-Jung Joachim
- Münch Richard
- Münzel Gustav
- Neue Hoffnung
- Nitz Genoveva
- Nobis Heribert M
- Nçrenberg Henning
- Oberlies Thomas
- Oettermann Stephan
- Olsson Herbert
- Orth Stefan
- Otto Gerd
- Otto Gerd
- Otto Gerd
- Pagenstecher Cord
- Pannenberg Wolfhart
- Pannenberg Wolfhart
- Pannenberg Wolfhart
- Pascal Blaise
- Paus Ansgar
- Penzinger Christine
- Pergande Frank
- Pergande Frank
- Peters Albrecht
- Petrarca Francesco
- Pezzoli-Olgiati Daria
- Pfeiffer Wolfgang
- Pfleiderer Georg
- Philipp Wolfgang
- Picht Georg
- Picht Georg
- Picht Georg
- Pizzoni Filippo
- Plessner Helmuth
- Plüss David
- Polkinghorne John
- Polkinghorne John
- Popko Maciej
- Poschmann Marion
- Poschmann Marion
- Poschmann Marion
- Proust Marcel
- Pçrksen Uwe
- Rapp Friedrich
- Rasmussen Larry
- Rathgeb Eduard
- Rau Gerhard
- Rauschenberger Johannes
- Redlich Peter
- Reichertz Jo
- Reichler Claude
- Reinhart Krüger
- Reuther Christina
- Reynolds Richard
- Richter
- Richter
- Riechelmann Cord
- Riechelmann Cord
- Riede Peter
- Riede Peter
- Rieger Hans-Martin
- Riesebrodt Martin
- Rietzschel Thomas
- Rilke Rainer Maria
- Ringleben Joachim
- Ritter Joachim
- Rohls Jan
- Rolshoven Johanna
- Rose Gllian
- Rothacker Erich
- Rothgangel Martin
- Rousseau Jean-Jaques
- Rçhring Klaus
- Rçmer Willy
- Rçssler Dietrich
- Sachsse Rolf
- Sagner-Düchting Karin
- Salza Prina Ricotti Eugenia
- Scattola Merio
- Schacht Ulrich
- Schade Claudia
- Scharfe Martin
- Scharfe Martin
- Schelsky Helmut
- Schian Martin
- Schian Martin
- Schibilsky Kretzschmar
- Schindler Uhlig
- Schirmer Stefan
- Schirmer Stefan
- Schleiermacher Friedrich D.E.
- Schleiermacher Friedrich D.E.
- Schlçgel Karl
- Schlçgel Karl
- Schlçsser Noichl
- Schmidt Andreas
- Schmidt Joachim
- Schmied Gerhard
- Schmitz Hermann
- Schmoll Friedemann
- Schmoll Heike
- Schneider Barbara
- Schneider Peter
- Schneider Ulrike
- Scholl Norbert
- Schroer Keel
- Schrçer Henning
- Schubert Jens Daniel
- Schurig Jçrg
- Schwebel Horst
- Schwemmer Oswald
- Schäfer Lothar
- Schäufler Nicole
- Schütz Luckmann
- Seel Martin
- Segebrecht Wulf
- Seidel Ulrich
- Seile Friedrich
- Seip Jçrg
- Sekretariat der Deutschen Bischofskonferenz
- Sektion Rankweil
- Serres Michel
- Shaftesbury
- Siefele Rolf Peter
- Siegfried Thielbeer
- Simmel Georg
- Simmel Georg
- Smedes Taede A
- Smoltczyk Alexander
- Soentgen Jens
- Sontag Susan
- Sparn Walter
- Spitzing Günter
- Stadler Frank
- Stadler Siegfried
- Stadler Siegfried
- Stadler Ulrich
- Stadtgrün Hannover
- Starl Timm
- Steck Wolfgang
- Steer Georg
- Steer Georg
- Stegemann Wolfgang
- Steiger Johann Anselm
- Steinbauer
- Steingräber Erich
- Steins Hartmut
- Stellrecht Irmtraud
- Stiegler Bernd
- Stoellger Philipp
- Stoellger Philipp
- Stoellger Philipp
- Stoker Wessel
- Strasser Stephan
- Stählin Wilhelm
- Stückelberger Johannes
- Sumowski Werner
- Swinne Axel
- Syamken Georg
- Sçderblom Kerstin
- Sçderblom Kerstin
- Sçkefeld Martin
- Sçlle Dorothee
- Sçlle Dorothee
- Sçrrensen Wolfgang
- Sçrries Reiner
- Tausch Frank
- Tausch Frank
- Theobald Werner
- Thomas Philipp
- Thomas Philipp
- Thomma Norbert
- Thraede Klaus
- Thurner Ingrid
- Thyen Hartwig
- Tietjen Friedrich
- Tillich Paul
- Treiber Angela
- Trepp Anne-Charlott
- Tricke Peer
- Tschofen Bernhard
- Urry John
- Veldhuis Henri
- Ven Johannes A
- Verk Sabine
- Vetter Ewald M
- Vierling-Ihrig Heike I
- Vogt Markus
- Volp Rainer
- Volz Hans
- Wagner Jan
- Wagner-Rau Ulrike
- Wagner-Rau Ulrike
- Waldenfels Bernhard
- Waldenfels Bernhard
- Waldenfels Bernhard
- Waldenfels Bernhard
- Waldenfels Bernhard
- Walter Francois
- Ward Nathaniel B
- Ward Nathaniel B
- Warnecke Peter
- Weber Max
- Weber Max
- Wehrli Christoph
- Weihe Richard
- Weippert Helga
- Weizäcker Carl
- Werber Niels
- Werner Schoepfle
- Werner Werner
- Wescoat James L
- Weyel Birgit
- Weyel Birgit
- Wiggermann F. A. M.
- Wild Reiner
- Wildenstein Daniel
- Wilken Franziska
- Willems Ad
- Willems Herbert
- Willis Peter
- Wissenschaften zu Berlin
- Wolf Norbert
- Wolff Barbara
- Wolff Stephan
- Wolff Stephan
- Ziegler Meinrad
- Zippert Thomas
- ün
- ür Gartengeniesser Mediaanalyse Eden
- ür Raumordnung
- ür Umfragen Methoden
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study