1,376 research outputs found
Trees of Unusual Size: Biased Inference of Early Bursts from Large Molecular Phylogenies
An early burst of speciation followed by a subsequent slowdown in the rate of
diversification is commonly inferred from molecular phylogenies. This pattern
is consistent with some verbal theory of ecological opportunity and adaptive
radiations. One often-overlooked source of bias in these studies is that of
sampling at the level of whole clades, as researchers tend to choose large,
speciose clades to study. In this paper, we investigate the performance of
common methods across the distribution of clade sizes that can be generated by
a constant-rate birth-death process. Clades which are larger than expected for
a given constant-rate branching process tend to show a pattern of an early
burst even when both speciation and extinction rates are constant through time.
All methods evaluated were susceptible to detecting this false signature when
extinction was low. Under moderate extinction, both the gamma-statistic and
diversity-dependent models did not detect such a slowdown but only because the
signature of a slowdown was masked by subsequent extinction. Some models which
estimate time-varying speciation rates are able to detect early bursts under
higher extinction rates, but are extremely prone to sampling bias. We suggest
that examining clades in isolation may result in spurious inferences that rates
of diversification have changed through time.Comment: 17 pages, 5 figure
A Suggested Initial Administrative Structure for a Contemplated Community College in Walla Walla
Responsible local educational and community leaders determined in 1961 that all legal criteria for the establishment of a community college in Walla Walla [Washington] had been met. They subsequently have been faced with many phases of preplanning activity. Among the problems requiring solution have been: the acquisition of adequate physical facilities, the determination of an operational financial plan, the establishment of accurate and efficient enrollment procedures, and the organization of an instructional and administrative staff. Much of the pre-planning has been completed. This study was designed to contribute to the thinking of the Board and staff of Walla Walla Public Schools when the time comes to appoint the initial administrative officers for the contemplated community college in Walla Walla
Impaired Right, Left, or Biventricular Function and Resting Oxygen Saturation Are Associated With Mortality in Eisenmenger Syndrome: A Clinical and Cardiovascular Magnetic Resonance Study.
Bacterial diversification through geological time
Numerous studies have estimated plant and animal diversification dynamics; however, no comparable rigorous estimates exist for bacteria—the most ancient and widespread form of life on Earth. Here, we analyse phylogenies comprising up to 448,112 bacterial lineages to reconstruct global bacterial diversification dynamics. To handle such large phylogenies, we developed methods based on the statistical properties of infinitely large trees. We further analysed sequencing data from 60 environmental studies to determine the fraction of extant bacterial diversity missing from the phylogenies—a crucial parameter for estimating speciation and extinction rates. We estimate that there are about 1.4–1.9 million extant bacterial lineages when lineages are defined by 99% similarity in the 16S ribosomal RNA gene, and that bacterial diversity has been continuously increasing over the past 1 billion years (Gyr). Recent bacterial extinction rates are estimated at 0.03–0.05 per lineage per million years (lineage^(–1) Myr^(–1)), and are only slightly below estimated recent bacterial speciation rates. Most bacterial lineages ever to have inhabited this planet are estimated to be extinct. Our findings disprove the notion that bacteria are unlikely to go extinct, and provide a valuable perspective on the evolutionary history of a domain of life with a sparse and cryptic fossil record
Early infant feeding and adiposity risk: from infancy to adulthood
Introduction: Systematic reviews suggest that a longer duration of breast-feeding is associated with a reduction in the risk of later overweight and obesity. Most studies examining breast-feeding in relation to adiposity have not used longitudinal analysis. In our study, we aimed to examine early infant feeding and adiposity risk in a longitudinal cohort from birth to young adulthood using new as well as published data.
Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study in Perth, W.A., Australia, were used to examine associations between breast-feeding and measures of adiposity at 1, 2, 3, 6, 8, 10, 14, 17, and 20 years.
Results: Breast-feeding was measured in a number of ways. Longer breast-feeding (in months) was associated with reductions in weight z-scores between birth and 1 year (β = -0.027; p \u3c 0.001) in the adjusted analysis. At 3 years, breast-feeding for \u3c4 months increased the odds of infants experiencing early rapid growth (OR 2.05; 95% CI 1.43-2.94; p \u3c 0.001). From 1 to 8 years, children breast-fed for ≤4 months compared to ≥12 months had a significantly greater probability of exceeding the 95th percentile of weight. The age at which breast-feeding was stopped and a milk other than breast milk was introduced (introduction of formula milk) played a significant role in the trajectory of the BMI from birth to 14 years; the 4-month cutoff point was consistently associated with a higher BMI trajectory. Introduction of a milk other than breast milk before 6 months compared to at 6 months or later was a risk factor for being overweight or obese at 20 years of age (OR 1.47; 95% CI 1.12-1.93; p = 0.005).
Discussion: Breast-feeding until 6 months of age and beyond should be encouraged and is recommended for protection against increased adiposity in childhood, adolescence, and young adulthood. Adverse long-term effects of early growth acceleration are fundamental in later overweight and obesity. Formula feeding stimulates a higher postnatal growth velocity, whereas breast-feeding promotes slower growth and a reduced likelihood of overweight and obesity. Biological mechanisms underlying the protective effect of breast-feeding against obesity are based on the unique composition and metabolic and physiological responses to human milk
Exodeconus flavus (I.M. Johnst.) Axelius & D'Arcy
Dpto Arequipa: TiabayaUniversidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentin
The Therapeutic Efficacy of Domestic Violence Victim Interventions
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The energy budget in Rayleigh-Benard convection
It is shown using three series of Rayleigh number simulations of varying
aspect ratio AR and Prandtl number Pr that the normalized dissipation at the
wall, while significantly greater than 1, approaches a constant dependent upon
AR and Pr. It is also found that the peak velocity, not the mean square
velocity, obeys the experimental scaling of Ra^{0.5}. The scaling of the mean
square velocity is closer to Ra^{0.46}, which is shown to be consistent with
experimental measurements and the numerical results for the scaling of Nu and
the temperature if there are strong correlations between the velocity and
temperature.Comment: 5 pages, 3 figures, new version 13 Mar, 200
The transatlantic Thames: Anglo-American tensions on the Victorian “stream of pleasure”
While it is widely understood that rivers took on new symbolic power as avatars of nationalism in the late nineteenth century, less examined is their use as a space for Transatlantic cultural flow, and transnational commentary and critique. This article explores the ways in which a variety of Americans abroad in this period centred the Thames – newly charged with nationalist sentiment – in their accounts of Britain. In particular, it analyses Elizabeth Robins and Joseph Pennell’s travel narrative The Stream of Pleasure, first published as the lead article in the ‘Midsummer Holiday Issue’ of The Century Magazine in 1889, as an exemplary text in which both artist and writer play with the image of the river in ways that chime with much wider Transatlantic debates at this moment
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