Correlation analysis between two fMRI connectivity attributes in aMCI.

<p>Scatter plots show the significant positive correlation between FC and CI in the dMPFC. (<i>p</i><0.05), and trending positive correlations between FC and CI in the rIPL and rLTC. (0.05≤<i>p</i>≤0.10). Each circle represents data from a single subject.</p

Relationship between CI and individual performance in aMCI.

<p>Scatter plots show the significantly positive correlation of CI in the dMPFC with MMSE (<i>A1</i>) and MoCA (<i>A2</i>) scores, and the significantly positive correlation of the vMPFC with MMSE (<i>B1</i>) and MoCA (<i>B2</i>) scores. Each circle represents data from one participant.</p

Demographics and Clinical/Cognitive Characteristics of the Participants.

a<p>The <i>p</i> value was obtained using a two-tail Pearson chi-square test.</p>b<p>The <i>p</i> value was obtained using a two-sample two-tail <i>t</i> test.</p

Spearman correlation between convergence indexes in regions with significantly altered EC and cognitive performance in aMCI group

a<p>significant correlation (p<0.05).</p>b<p>correlation trend (0.05≤p≤0.10).</p

Relationship between FC and individual performance in aMCI.

<p>Scatter plots show the significantly positive correlation between FC in the dMPFC with MMSE (<i>A1</i>) and MoCA (<i>A2</i>) scores, and the significant negative correlation between the rLTC with MMSE (<i>B1</i>) and MoCA (<i>B2</i>) scores. Each circle represents data from a single participant.</p

The functional connectivity map of the DMN.

<p>The statistical map was derived from a one sample t-test (<i>p</i><0.05, corrected by FDR) of all subjects' DMN components. Bar at the right shows <i>T</i>-values.</p

Scatter plot of the CI in the rIPL.

<p>The circles represent the data from individual subjects. The histogram and the error bar show the within-group mean value, and the standard deviation. A declining line between the two histograms indicates a significantly decreased CI in the rIPL from NC to aMCI.</p

Characteristics of the study population for CAD.

<p>Data are shown as mean +/- standard deviation (SD) for quantitative variables and % for qualitative variables.</p><p>CAD: coronary artery disease; HDL-c: high density lipoprotein cholesterol levels; LDL-c, low density lipoprotein cholesterol levels; n.a: no data</p><p>*Age at the first diagnosis of the disease in CAD cases and age at enrollment for CAD controls.</p><p>^†<i>P</i> value for comparison of means for quantitative data with a student t-test, and for comparison of distribution of qualitative variables between cases and controls with a Chi-square test.</p><p>Characteristics of the study population for CAD.</p

Analysis of association of SNP rs9943582 with echocardiographic parameters.

<p>CAD: coronary artery disease, LV: left ventricle, LVSD: left ventricle systolic dysfunction, LVEF: left ventricle eject fraction.</p><p>Analysis of association of SNP rs9943582 with echocardiographic parameters.</p

Characteristics of the CAD group with LVSD and the CAD group with normal LVEF.

<p>Data are shown as mean +/- standard deviation (SD) for quantitative variables and % for qualitative variables.</p><p>CAD: coronary artery disease, HDL-c: high density lipoprotein cholesterol levels; LDL-c, low density lipoprotein cholesterol levels, LVSD: left ventricle systolic dysfunction, LVEF: left ventricle eject fraction.</p><p>*Age at the first diagnosis of the disease for CAD cases and age at enrollment for CAD controls.</p><p>^†<i>P</i> values for comparison of means for quantitative data with a student t-test, and for comparison of distribution of qualitative variables between CAD patients with LVSD and CAD patients with normal LVEF with a Chi-square test.</p><p>Characteristics of the CAD group with LVSD and the CAD group with normal LVEF.</p